公开(公告)号：US20220105167A1

公开(公告)日：2022-04-07

申请号：US17251973

申请日：2019-06-12

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA ,  Institut National de Recherche pour l'Agriculture, l'Alimentation et I'Environnement

Inventor： Mickael DESVAUX ,  Mariagrazia PIZZA ,  Maricarmen ROJAS-LOPEZ ,  Roberto ROSINI

IPC: A61K39/108 ,  C12Q1/689 ,  C07K14/245 ,  A61P31/04

Abstract: The present invention is direct to isolated polypeptides comprising or consisting of: an amino acid sequence selected from the group consisting of SEQ ID NOs: 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47 or 48; or (a) a variant and/or fragment of (a), for example: (i) a variant of (a); (ii) a fragment of (a); or (iii) a variant of a fragment of (a); together with corresponding isolated nucleic acid molecules, vectors, host cells, methods of production, vesicles, binding moieties, pharmaceutical compositions, kits, methods of treatment and medical uses.

公开(公告)号：US20240115688A1

公开(公告)日：2024-04-11

申请号：US18255442

申请日：2021-11-30

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Roberto ADAMO ,  Roberta COZZI ,  Adele FANTONI ,  Sanjay PHOGAT ,  Roberto ROSINI ,  Maria SCARSELLI ,  Newton WAHOME

IPC: A61K39/12 ,  C07K14/005 ,  C07K14/245

CPC classification number: A61K39/12 ,  C07K14/005 ,  C07K14/245 ,  A61K2039/55572

Abstract: The present invention is directed to novel, modified FimH polypeptides, nucleic acids encoding them, and the use of the polypeptides and nucleic acids in the treatment and/or prevention of disease, in particular, urinary tract infection (UTI).