公开(公告)号：US20230192745A1

公开(公告)日：2023-06-22

申请号：US16620900

申请日：2018-07-12

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Roberto ADAMO ,  Linda DEL BINO

IPC: C07H1/06 ,  C07H15/04 ,  A61K47/64

CPC classification number: C07H1/06 ,  C07H15/04 ,  A61K47/6415

Abstract: The present invention generally refers to novel intermediate polysaccharide units, useful for the preparation of polysaccharide antigen of GBS Ia, Ib and III; the invention also refers to a process for their preparation and their use as intermediate for the preparation of conjugated derivatives useful in vaccines.

公开(公告)号：US20220387614A1

公开(公告)日：2022-12-08

申请号：US17773637

申请日：2020-11-19

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Roberto ADAMO ,  Giuseppe DEL GIUDICE ,  Sanjay PHOGAT

IPC: A61K47/64 ,  A61K39/112 ,  A61K39/09

Abstract: The present invention provides a glycoconjugate for administration to a subject in a method comprising the steps of: (i) administering a first dose of glycoconjugate; (ii) subsequently administering a second dose of glycoconjugate; wherein the amount of glycoconjugate in the first dose or first and second doses are atypically low, and also related aspects.

公开(公告)号：US20230346905A1

公开(公告)日：2023-11-02

申请号：US18042355

申请日：2021-08-23

Applicant: GlaxosmithKline Biologicals SA

Inventor： Roberto ADAMO ,  Maria Rosaria ROMANO ,  Marta TONTINI

IPC: A61K39/095 ,  A61P31/04

CPC classification number: A61K39/095 ,  A61P31/04 ,  A61K2039/70

Abstract: The inventors have identified a combined vaccine for immunisation against bacterial meningitis caused by multiple pathogens.

公开(公告)号：US20230210975A1

公开(公告)日：2023-07-06

申请号：US18008777

申请日：2021-06-11

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Roberto ADAMO ,  Filippo CARBONI ,  Roberta COZZI ,  Immaculada MARGARIT Y ROS ,  Maria Rosaria ROMANO

IPC: A61K39/09 ,  A61P31/04

CPC classification number: A61K39/092 ,  A61P31/04 ,  A61K2039/6031

Abstract: Methods of inducing an immunogenic response against a bacterial polysaccharide or oligosaccharide, and constructs and compositions for use in such methods.

公开(公告)号：US20240115688A1

公开(公告)日：2024-04-11

申请号：US18255442

申请日：2021-11-30

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Roberto ADAMO ,  Roberta COZZI ,  Adele FANTONI ,  Sanjay PHOGAT ,  Roberto ROSINI ,  Maria SCARSELLI ,  Newton WAHOME

IPC: A61K39/12 ,  C07K14/005 ,  C07K14/245

CPC classification number: A61K39/12 ,  C07K14/005 ,  C07K14/245 ,  A61K2039/55572

Abstract: The present invention is directed to novel, modified FimH polypeptides, nucleic acids encoding them, and the use of the polypeptides and nucleic acids in the treatment and/or prevention of disease, in particular, urinary tract infection (UTI).

公开(公告)号：US20220152183A1

公开(公告)日：2022-05-19

申请号：US17436692

申请日：2020-03-06

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Roberto ADAMO ,  Francesco BERTI ,  Paolo COSTANTINO ,  Luigi LAY

IPC: A61K39/095 ,  A61K47/64 ,  A61P31/00 ,  C08B37/00

Abstract: The invention is in the field of vaccines and relates to oligomers having a selected degree of polymerization, obtained by connecting together a number of carbocyclic repeating units, and to conjugated derivatives thereof. The oligomers and conjugated derivatives thereof of the invention also have a selected degree of acetylation. The derivatives of the invention are useful for the preparation of immunogenic compositions, e.g. in the form of a vaccine.