公开(公告)号：US20220387614A1

公开(公告)日：2022-12-08

申请号：US17773637

申请日：2020-11-19

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Roberto ADAMO ,  Giuseppe DEL GIUDICE ,  Sanjay PHOGAT

IPC: A61K47/64 ,  A61K39/112 ,  A61K39/09

Abstract: The present invention provides a glycoconjugate for administration to a subject in a method comprising the steps of: (i) administering a first dose of glycoconjugate; (ii) subsequently administering a second dose of glycoconjugate; wherein the amount of glycoconjugate in the first dose or first and second doses are atypically low, and also related aspects.

公开(公告)号：US20240115688A1

公开(公告)日：2024-04-11

申请号：US18255442

申请日：2021-11-30

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Roberto ADAMO ,  Roberta COZZI ,  Adele FANTONI ,  Sanjay PHOGAT ,  Roberto ROSINI ,  Maria SCARSELLI ,  Newton WAHOME

IPC: A61K39/12 ,  C07K14/005 ,  C07K14/245

CPC classification number: A61K39/12 ,  C07K14/005 ,  C07K14/245 ,  A61K2039/55572

Abstract: The present invention is directed to novel, modified FimH polypeptides, nucleic acids encoding them, and the use of the polypeptides and nucleic acids in the treatment and/or prevention of disease, in particular, urinary tract infection (UTI).