公开(公告)号：US20170246290A1

公开(公告)日：2017-08-31

申请号：US15446508

申请日：2017-03-01

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： William Ripley BALLOU ,  Emmanuel Jules HANON

IPC: A61K39/145 ,  C12N7/00

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55566 ,  A61K2039/55577 ,  A61K2039/70 ,  C12N7/00 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16234 ,  C12N2760/16251 ,  Y02A50/41

Abstract: The present invention provides an immunogenic influenza composition in a dose volume suitable for human use, comprising an influenza virus antigen or antigenic preparation thereof and an adjuvant composition comprising an oil-in-water emulsion, wherein said oil-in-water emulsion comprises a metabolisable oil at a level of below 11 mg and an emulsifying agent at a level of below 5 mg and optionally a tocol or a sterol at a level of below 12 mg. Suitably the amount of influenza antigen per strain per dose is 15 μg HA or a low amount such as less than 15 μg HA.