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    INFLUENZA VACCINE
    1.
    发明公开
    INFLUENZA VACCINE 审中-公开

    公开(公告)号：US20230201329A1

    公开(公告)日：2023-06-29

    申请号：US18077481

    申请日：2022-12-08

    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

    Inventor： Emmanuel Jules HANON ,  Jean STEPHENNE

    IPC: A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  C12N7/00

    CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  C12N7/00 ,  A61K2039/5252

    Abstract: The present invention relates to monovalent influenza vaccine formulations and vaccination regimes for immunising against influenza disease, their use in medicine, in particular their use in augmenting immune responses to various antigens, and to methods of preparation. In particular, the invention relates to monovalent influenza immunogenic compositions comprising an influenza antigen or antigenic preparation thereof from an influenza virus strain being associated with a pandemic outbreak or having the potential to be associated with a pandemic outbreak, in combination with an oil-in-water emulsion adjuvant comprising a metabolisable oil, a sterol and/or a tocopherol such as alpha tocopherol, and an emulsifying agent.

    INFLUENZA VACCINE
    4.
    发明申请
    INFLUENZA VACCINE 有权
    流感疫苗

    公开(公告)号：US20160256537A1

    公开(公告)日：2016-09-08

    申请号：US14996446

    申请日：2016-01-15

    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

    Inventor： Emmanuel Jules HANON ,  Jean STEPHENNE

    IPC: A61K39/145 ,  C12N7/00 ,  A61K39/39

    CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/572 ,  A61K2039/575 ,  C12N7/00 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2760/16234

    Abstract: The present invention relates to monovalent influenza vaccine formulations and vaccination regimes for immunising against influenza disease, their use in medicine, in particular their use in augmenting immune responses to various antigens, and to methods of preparation. In particular, the invention relates to monovalent influenza immunogenic compositions comprising an influenza antigen or antigenic preparation thereof from an influenza virus strain being associated with a pandemic outbreak or having the potential to be associated with a pandemic outbreak, in combination with an oil-in-water emulsion adjuvant comprising a metabolisable oil, a sterol and/or a tocopherol such as alpha tocopherol, and an emulsifying agent.

    Abstract translation: 本发明涉及用于免疫流感病毒的单价流感疫苗制剂和疫苗接种方案，它们在医学中的用途，特别是它们在增强对各种抗原的免疫应答中的用途以及制备方法。 特别地，本发明涉及包含流感病毒抗原或其抗原制品的单价流感免疫原性组合物，该流感病毒抗原或其抗原制品与流感大流行爆发相关或具有与大流行性流感相关联的流感病毒株， 水乳液佐剂，其包含可代谢的油，固醇和/或生育酚如α-生育酚和乳化剂。

    ADJUVANTED INFLUENZA VIRUS COMPOSITIONS
    5.
    发明申请
    ADJUVANTED INFLUENZA VIRUS COMPOSITIONS 有权
    受感染的流感病毒组合物

    公开(公告)号：US20140363474A1

    公开(公告)日：2014-12-11

    申请号：US14465055

    申请日：2014-08-21

    Applicant: GlaxoSmithKline Biologicals, sa

    Inventor： Emmanuel Jules HANON ,  Jean STEPHENNE

    IPC: A61K39/145 ,  C12N7/00 ,  A61K39/39

    CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/55 ,  A61K2039/55511 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/57 ,  A61K2039/70 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16134 ,  C12N2760/16234

    Abstract: The present invention relates to influenza vaccine formulations and vaccination regimes for immunising against influenza disease, their use in medicine, in particular their use in augmenting immune responses to various antigens, and to methods of preparation. In particular, the invention relates to multivalent influenza immunogenic compositions comprising an influenza antigen or antigenic preparation thereof from at least two influenza virus strains, at least one strain being associated with a pandemic outbreak or having the potential to be associated with a pandemic outbreak, in combination with an oil-in-water emulsion adjuvant.

    Abstract translation: 本发明涉及用于免疫流感病毒的流感疫苗制剂和疫苗接种方案，它们在医学中的用途，特别是它们在增强对各种抗原的免疫应答中的用途以及制备方法。 特别地，本发明涉及包含来自至少两种流感病毒株的流感抗原或其抗原制剂的多价流感免疫原性组合物，至少一种与大流行性流感相关的菌株或可能与大流行性流感相关联， 与水包油乳剂佐剂组合。

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