公开(公告)号：US20240165224A1

公开(公告)日：2024-05-23

申请号：US18283516

申请日：2022-03-25

申请人： GLAXOSMITHKLINE BIOLOGICALS SA ,  UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Ventzislav Bojidarov VASSILEV ,  Corey MALLETT ,  Ronan ROUXEL ,  Normand BLAIS ,  Masaru KANEKIYO ,  Barney S. GRAHAM

IPC分类号： A61K39/39 ,  A61K39/00 ,  A61K39/145 ,  A61P31/16 ,  A61P37/04

CPC分类号： A61K39/39 ,  A61K39/145 ,  A61P31/16 ,  A61P37/04 ,  A61K2039/55566 ,  A61K2039/6031

摘要： The present invention relates to influenza virus immunisation using at least one influenza HA stem polypeptide in conjunction with squalene emulsion adjuvants, and to related aspects.

公开(公告)号：US20240181038A1

公开(公告)日：2024-06-06

申请号：US18283632

申请日：2022-03-25

申请人： GLAXOSMITHKLINE BIOLOGICALS SA ,  UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Ventzislav Bojidarov VASSILEV ,  Corey MALLETT ,  Ronan ROUXEL ,  Normand BLAIS ,  Masaru KANEKIYO ,  Barney S. GRAHAM

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61K39/385 ,  A61P31/16 ,  C07K14/005

CPC分类号： A61K39/145 ,  A61K39/385 ,  A61P31/16 ,  C07K14/005 ,  A61K2039/53 ,  A61K2039/55555 ,  C12N2760/16122 ,  C12N2760/16134

摘要： The present invention relates to a carrier-formulated mRNA comprising at least one coding sequence encoding an influenza HA stem polypeptide, and to related aspects.