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公开(公告)号：US12129514B2
公开(公告)日：2024-10-29
申请号：US13934093
申请日：2013-07-02
发明人： Gregory J. Porreca , Mark Umbarger
IPC分类号： C12Q1/6813 , C12Q1/6827 , C12Q1/6886
CPC分类号： C12Q1/6813 , C12Q1/6827 , C12Q1/6886 , C12Q2537/159 , C12Q2600/156 , C12Q1/6827 , C12Q2535/122 , C12Q2537/159 , C12Q2537/162 , C12Q1/6827 , C12Q2525/307 , C12Q2535/122 , C12Q2537/159
摘要： Aspects of the invention relates to methods and compositions that are useful to reduce bias and increase the reproducibility of multiplex analysis of genetic loci. In some configurations, predetermined preparative steps and/or nucleic acid sequence analysis techniques are used in multiplex analyses for a plurality of genetic loci in a plurality of samples.
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公开(公告)号：US20240233868A9
公开(公告)日：2024-07-11
申请号：US18482779
申请日：2023-10-06
IPC分类号： G16B30/00 , C12Q1/6806 , C12Q1/6827 , G16B5/00 , G16B25/10 , G16B40/30
CPC分类号： G16B30/00 , C12Q1/6806 , C12Q1/6827 , G16B5/00 , G16B25/10 , G16B40/30 , C12Q2535/122 , C12Q2537/159
摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.
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公开(公告)号：US11959141B2
公开(公告)日：2024-04-16
申请号：US15529237
申请日：2015-12-04
发明人： Geoffrey Alan Otto , Michelle Nahas , Doron Lipson
IPC分类号： C12Q1/68 , C12N15/10 , C12Q1/6806 , C12Q1/6886 , G16B25/00 , G16B25/10 , G16B30/00 , G16B30/10 , G16B45/00
CPC分类号： C12Q1/6886 , C12N15/1065 , C12Q1/6806 , G16B25/00 , G16B25/10 , G16B30/00 , G16B30/10 , G16B45/00 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q1/6806 , C12Q2535/122 , C12Q2537/159 , C12Q2563/131
摘要： Methods of evaluating or providing a clonal profile of a subject interval, e.g., a subgenomic interval, or an expressed subgenomic interval (or of a cell containing the same), in a subject, are disclosed.
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公开(公告)号：US20240087680A1
公开(公告)日：2024-03-14
申请号：US18503392
申请日：2023-11-07
IPC分类号： G16B30/00 , C12Q1/6806 , C12Q1/6827 , G16B5/00 , G16B25/10 , G16B40/30
CPC分类号： G16B30/00 , C12Q1/6806 , C12Q1/6827 , G16B5/00 , G16B25/10 , G16B40/30 , C12Q2535/122 , C12Q2537/159
摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.
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公开(公告)号：US11802308B2
公开(公告)日：2023-10-31
申请号：US16912622
申请日：2020-06-25
申请人： SPEEDX PTY LTD
发明人： Alison Velyian Todd , Elisa Mokany , Samantha Walker , Cortny Donald , Dina Lonergan , Lit Yeen Tan
IPC分类号： C12Q1/6858 , C12Q1/6818 , C12Q1/6853 , C12Q1/6848 , C12N15/113
CPC分类号： C12Q1/6858 , C12N15/113 , C12Q1/6818 , C12Q1/6848 , C12Q1/6853 , C12N2310/12 , C12Q1/6858 , C12Q2525/161 , C12Q2535/125 , C12Q1/6853 , C12Q2525/161 , C12Q2537/159 , C12Q1/6818 , C12Q2521/345 , C12Q2535/131
摘要： The present invention provides modified oligonucleotides and methods for their use in the detection of nucleic acids. The oligonucleotides and methods find particular application in amplifying and/or detecting areas of genetic variation in target nucleic acid sequences.
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公开(公告)号：US11802305B2
公开(公告)日：2023-10-31
申请号：US15738469
申请日：2016-06-24
IPC分类号： C12Q1/6827 , C12Q1/6883 , C12Q1/6886 , G16H50/70 , G16B40/00
CPC分类号： C12Q1/6827 , C12Q1/6883 , C12Q1/6886 , G16B40/00 , G16H50/70 , C12Q2521/501 , C12Q2523/101 , C12Q2537/159 , C12Q2600/106
摘要： A process for analysing epigenetically active regions of the genome.
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公开(公告)号：US11795578B2
公开(公告)日：2023-10-24
申请号：US17728093
申请日：2022-04-25
申请人： Illumina, Inc.
IPC分类号： C40B30/04 , C12N15/10 , C12Q1/6806 , C12Q1/6874
CPC分类号： C40B30/04 , C12N15/1096 , C12Q1/6806 , C12Q1/6874 , C12Q1/6806 , C12Q2521/301 , C12Q2525/191 , C12Q2527/107 , C12Q2535/122 , C12Q2537/159 , C12Q2563/131 , C12N15/1096 , C12Q2521/301 , C12Q2525/191 , C12Q2527/107 , C12Q2535/122 , C12Q2537/159 , C12Q2563/131
摘要： Presented herein are methods and compositions for analyzing rare nucleic acid species. Some methods presented herein use DNA reassociation kinetics following thermal denaturation to define populations of nucleic acid sequences, e.g., highly abundant (e.g., cDNA from rRNA), moderately abundant, and less abundant or rare sequences (e.g., cDNA from mRNA).
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公开(公告)号：US20190241978A1
公开(公告)日：2019-08-08
申请号：US16389596
申请日：2019-04-19
申请人： Inivata Ltd.
发明人： Samuel Woodhouse , Stefanie Lensing , Tim Forshew , Vincent Plagnol , Matthew Edward Smith , Karen Howarth , Michael Epstein
IPC分类号： C12Q1/6886 , C12Q1/6853
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q1/6853 , C12Q1/686 , C12Q2600/106 , C12Q2600/16 , G16B20/00 , G16B30/00 , C12Q2525/155 , C12Q2525/161 , C12Q2531/113 , C12Q2535/122 , C12Q2537/159
摘要： The present disclosure relates to methods for detecting and targeting genomic rearrangements, in particular gene fusion events, by targeting a DNA molecule of interest with a set or pool of primers, wherein the forward primers and reverse primers produce a PCR amplification product when a genomic rearrangement is present. The present disclosure also relates to methods of bioinformatic analysis to determine whether or not the detection of an amplification product from the selective PCR is actually indicative of the presence of a gene fusion. The present disclosure also related to related methods of diagnosis and treatment of diseases and conditions associated with such genomic rearrangements, in particular cancers, such as lung cancer.
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公开(公告)号：US20190144920A1
公开(公告)日：2019-05-16
申请号：US16231338
申请日：2018-12-21
申请人： Arc Bio, LLC
IPC分类号： C12Q1/6806 , C12Q1/6874 , C12N15/11 , C12N9/22
CPC分类号： C12Q1/6806 , C12N9/22 , C12N15/11 , C12N2310/20 , C12N2800/80 , C12Q1/6874 , C12Q2521/301 , C12Q2521/319 , C12Q2537/159 , C12Q2563/131 , C12Q2525/191 , C12Q2531/113
摘要： Provided herein are methods and compositions for depleting targeted nucleic acid sequences from a sample, enriching for sequences of interest from a sample, and/or partitioning of sequences from a sample. The methods and compositions are applicable to biological, clinical, forensic, and environmental samples.
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公开(公告)号：US20190062730A1
公开(公告)日：2019-02-28
申请号：US15945050
申请日：2018-04-04
IPC分类号： C12N15/10
CPC分类号： C12N15/1065 , C12N15/1051 , C12N15/1058 , C12N15/1086 , C12Q2537/159
摘要： Described herein is a method for identifying synthetic inducible promoters that have specified induction and/or repression for DNA binding proteins such as an allosteric transcription factor and an inducer molecule. The method includes an in vitro selection from an unselected polynucleotide library comprising a plurality of random degeneracies, and an in vivo selection to produce an induced promoter library. Produced is an induction table, which allows the selection of a promoter with specific induction and/or repression properties. Also included are biosensors containing the synthetic inducible promoters.
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