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公开(公告)号：US20190169375A1
公开(公告)日：2019-06-06
申请号：US16322615
申请日：2017-08-02
发明人： Rachel AUZELY-VELTY , Tamiris FIGUEIREDO , Laura JING JING , Craig Steven HARRIS , Jean-Guy BOITEAU , Thibaut GERFAUD , Loic TOMAS
IPC分类号： C08J3/075 , C08L5/08 , C08K5/55 , C08K5/1545
摘要： A new hydrogel made of crosslinked glycosaminoglycans, particularly crosslinked hyaluronic acid, chondroitin or chondroitin sulfate, having reversible linkages using boronic acid or boroxole derivatives leading to new benefits. Glycosaminoglycans that are crosslinked via an alkoxyboronate ester anion formed between a diol portion of a diol-functional moiety grafted to a first glycosaminoglycan and a boronate hemiester grafted to a second glycosaminoglycan.
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公开(公告)号：US20220081519A1
公开(公告)日：2022-03-17
申请号：US17535314
申请日：2021-11-24
发明人： Rachel AUZELY-VELTY , Tamiris FIGUEIREDO , Laura JING JING , Craig Steven HARRIS , Jean-Guy BOITEAU , Thibaut GERFAUD , Loic TOMAS
IPC分类号： C08J3/075 , C08L5/08 , C08K5/55 , C08K5/1545 , C08J3/24 , C08B37/00 , C08B37/08 , A61K31/728
摘要： A new hydrogel made of crosslinked glycosaminoglycans, particularly crosslinked hyaluronic acid, chondroitin or chondroitin sulfate, having reversible linkages using boronic acid or boroxole derivatives leading to new benefits. Glycosaminoglycans that are crosslinked via an alkoxyboronate ester anion formed between a diol portion of a diol-functional moiety grafted to a first glycosaminoglycan and a boronate hemiester grafted to a second glycosaminoglycan.
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公开(公告)号：US20200062868A1
公开(公告)日：2020-02-27
申请号：US16322713
申请日：2017-08-02
发明人： Rachel AUZELY-VELTY , Tamiris FIGUEIREDO , Laura JING JING , Craig Steven HARRIS , Jean-Guy BOITEAU , Thibaut GERFAUD , Loic TOMAS
摘要： A new hydrogel made of crosslinked glycosaminoglycans, particularly crosslinked hyaluronic acid, chondroitin or chondroitin sulfate, having reversible linkages using boroxole derivatives leading to new benefits. Glycosaminoglycans that are crosslinked via an alkoxyboronate ester anion formed between a backbone diol function of a first glycosaminoglycan and a boronate hemiester grafted to a second glycosaminoglycan.
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公开(公告)号：US20200002441A1
公开(公告)日：2020-01-02
申请号：US16322653
申请日：2017-08-02
发明人： Rachel AUZELY-VELTY , Tamiris FIGUEIREDO , Laura JING JING , Craig Steven HARRIS , Jean-Guy BOITEAU , Thibaut GERFAUD , Loic TOMAS
摘要： A new hydrogel made of double crosslinked glycosaminoglycans, particularly crosslinked hyaluronic acid, chondroitin or chondroitin sulfate, having reversible linkages using boronic acid or boroxole derivatives leading to new benefits. Double crosslinked glycosaminoglycans, one linkage via two ether bonds with a hydroxyl group of each of two glycosaminoglycans and another linkage via an alkoxyboronate ester anion formed between a boronate hemiester grafted to one of the glycosaminoglycans and a diol function of to the other glycosaminoglycan. The diol function may be a backbone diol function or a diol portion of a diol functional moiety grafted the other glycosaminoglycan.
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5.发明申请NOVEL BIAROMATIC COMPOUNDS THAT MODULATE PPARY TYPE RECEPTORS AND COSMETIC/PHARMACEUTICAL COMPOSITIONS COMPRISED THEREOF 审中-公开调节PPAR类型受体的新型BIAROMATIC化合物及其包含的化妆品/药物组合物公开(公告)号：US20130303549A1
公开(公告)日：2013-11-14
申请号：US13939153
申请日：2013-07-10
IPC分类号： C07D333/24 , C07D213/55 , C07D307/54 , C07D239/26
CPC分类号： C07D333/24 , C07D213/55 , C07D213/75 , C07D239/26 , C07D239/42 , C07D307/54
摘要： Novel biaromatic compounds having the general formula (I): and cosmetic/pharmaceutical compositions comprised thereof are useful in human or veterinary medicine (in dermatology and also in the fields of cardiovascular diseases, of immune diseases and/of diseases related to the metabolism of lipids), or, alternatively, in cosmetic compositions.
摘要翻译： 具有通式（I）的新型双芳族化合物及其包含的化妆品/药物组合物可用于人或兽医学（在皮肤病学领域以及心血管疾病，免疫疾病和/或与脂质代谢有关的疾病领域 ），或者在化妆品组合物中。
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6.发明申请公开(公告)号：US20190010124A1
公开(公告)日：2019-01-10
申请号：US15780164
申请日：2016-11-08
IPC分类号： C07D213/75 , C07C51/02 , C07D213/73
CPC分类号： C07D213/75 , C07C51/02 , C07D213/73 , C07D239/52
摘要： The present invention relates to a novel process for preparing enantiomerically pure compounds of N-(pyrid-4-yl)-2-hydroxyalkylamide type corresponding to the general formula (C) below: and also to processes for preparing the reaction intermediates used in this synthesis, said intermediates having the general formulae (A) and (B) below:
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7.发明申请DISUBSTITUTED 3,4-DIAMINO-3-CYCLOBUTENE-1,2-DIONE COMPOUNDS FOR USE IN THE TREATMENT OF CHEMOKINE-MEDIATED DISEASES 有权用于治疗介导性疾病的3,4-DIAMINO-3-CYCLOBUTENE-1,2-DIONE化合物公开(公告)号：US20160166562A1
公开(公告)日：2016-06-16
申请号：US14707551
申请日：2015-05-08
发明人： Branislav MUSICKI , Jerôme AUBERT , Patricia ROSSIO , Marlène SCHUPPLI-NOLLET , Laurence CLARY , Jean-Guy BOITEAU
IPC分类号： A61K31/4525 , A61K31/382 , A61K31/351
CPC分类号： A61K31/4525 , A61K31/351 , A61K31/382 , C07D405/06 , C07D407/06 , C07D409/06
摘要： Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds corresponding to general formula (I) are disclosed. Also disclosed, are pharmaceutical compositions including these compounds and methods of using these compounds and compositions for the treatment of chemokine-mediated diseases.
摘要翻译： 公开了对应于通式（I）的二取代的3,4-二氨基-3-环丁烯-1,2-二酮化合物。 还公开了包括这些化合物的药物组合物和使用这些化合物和组合物治疗趋化因子介导的疾病的方法。
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8.发明申请METHOD FOR THE SYNTHESIS OF 4-(HETEROCYCLOALKYL)-BENZENE-1,3,-DIOL COMPOUNDS 有权合成4-（杂环烷基） - 苯基-1,3-二醇化合物的方法公开(公告)号：US20160185749A1
公开(公告)日：2016-06-30
申请号：US14767762
申请日：2014-02-14
发明人： Jean-Guy BOITEAU
IPC分类号： C07D335/02 , C07D309/06
CPC分类号： C07D335/02 , C07D309/06 , C07D309/10
摘要： A method is described for the synthesis of 4-(heterocycloalkyl)-benzene-1,3-diol compounds of general formulae (I) and (II): wherein X can be an oxygen atom or a sulphur atom. Also described, is a method for the synthesis of the reactive intermediates of general formula (7a) or (7b) Novel compounds as synthesis intermediates are also described.
摘要翻译： 描述了用于合成通式（I）和（II）的4-（杂环烷基） - 苯-1,3-二醇化合物的方法：其中X可以是氧原子或硫原子。 还描述了用于合成通式（7a）或（7b）的反应性中间体的方法也描述了作为合成中间体的新型化合物。
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9.发明申请METHOD FOR THE SYNTHESISING 4-PIPERIDIN-4-YL-BENZENE-1,3-DIOL AND THE SALTS OF SAME AND NOVEL COMPOUND TERT-BUTYL 4-(2,4-DIHYDROXY-PHENYL)-4-HYDROXY-PIPERIDINE-1-CARBOXYLATE 有权合成4-哌啶-4-基 - 苯甲-1,3-二醇的方法及其相同和新型化合物叔丁基-4-（2,4-二羟基苯基）-4-羟基 - 哌啶-1-基 - 羧甲酸酯公开(公告)号：US20150376126A1
公开(公告)日：2015-12-31
申请号：US14767544
申请日：2014-02-14
IPC分类号： C07D211/52 , C07D211/22
CPC分类号： C07D211/52 , C07B35/02 , C07D211/22
摘要： A method is described for the synthesis of 4-piperidin-4-yl-benzene-1,3-diol of the following formula (I): and the pharmaceutically acceptable salts thereof. Also described, is tert-butyl 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate as a novel intermediate compound
摘要翻译： 描述了用于合成下式（I）的4-哌啶-4-基 - 苯-1,3-二醇的方法及其药学上可接受的盐。 还描述了作为新型中间体化合物的4-（2,4-二羟基 - 苯基）-4-羟基 - 哌啶-1-甲酸叔丁酯
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10.发明申请4-(AZACYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS 有权4-（齐克洛尔基）苯甲腈-1,3-二醇化合物作为酪氨酸酶抑制剂，其制备方法及其在人体药物和化妆品中的应用公开(公告)号：US20140371197A1
公开(公告)日：2014-12-18
申请号：US14469199
申请日：2014-08-29
IPC分类号： C07D401/12 , A61K9/06 , C07D211/22 , C07D211/26 , C07D205/04 , C07D207/08
CPC分类号： C07D401/12 , A61K9/06 , C07D205/04 , C07D207/08 , C07D207/16 , C07D211/22 , C07D211/26 , C07D211/60
摘要： 4-(Azacycloalkyl)benzene-1,3-diol compounds are described corresponding to general formula (I) below: Also described, are compositions including the same, processes for preparation thereof and uses thereof in pharmaceutical or cosmetic compositions to treat pigmentary disorders.
摘要翻译： 4-（氮杂环烷基）苯-1,3-二醇化合物对应于下列通式（I）所述：还描述了包含它们的组合物，其制备方法及其在药物或化妆品组合物中用于治疗色素障碍的用途。
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