公开(公告)号：US11878160B2

公开(公告)日：2024-01-23

申请号：US15752502

申请日：2016-08-18

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Michael John Carr ,  Kevin K. Kwong ,  Gerald E. Hunsberger

IPC: A61N1/20 ,  A61N1/36 ,  A61B5/388 ,  A61B5/08 ,  A61B5/087 ,  A61B5/091 ,  A61B5/145 ,  A61B5/00

CPC classification number: A61N1/205 ,  A61B5/087 ,  A61B5/0816 ,  A61B5/091 ,  A61B5/14542 ,  A61B5/388 ,  A61B5/4035 ,  A61B5/4836 ,  A61N1/3611 ,  A61N1/36053 ,  A61N1/36057 ,  A61N1/36171 ,  A61B5/08

Abstract: The present invention provides devices and methods that can prevent or ameliorate bronchoconstriction by stimulating neural activity, in contrast to those techniques based on denervation, ablation or blocking of neural activity. Methods and devices according to the invention may act responsively or on demand, can preserve neuronal structure and function and will be associated with minimal collateral side-effects. In particular, the invention provides devices and methods in which a signal is delivered to the vagus nerve, for example the cervical vagus nerve or the pulmonary branch of the vagus nerve, in order to stimulate neural activity in the vagal nerve.

公开(公告)号：US20240131327A1

公开(公告)日：2024-04-25

申请号：US18537151

申请日：2023-12-12

Applicant: Galvani Bioelectronics Limited

Inventor： Michael John Carr ,  Kevin K. Kwong ,  Gerald E. Hunsberger

IPC: A61N1/20 ,  A61B5/00 ,  A61B5/08 ,  A61B5/087 ,  A61B5/091 ,  A61B5/145 ,  A61B5/388 ,  A61N1/36

CPC classification number: A61N1/205 ,  A61B5/0816 ,  A61B5/087 ,  A61B5/091 ,  A61B5/14542 ,  A61B5/388 ,  A61B5/4035 ,  A61B5/4836 ,  A61N1/36053 ,  A61N1/36057 ,  A61N1/3611 ,  A61N1/36171 ,  A61B5/08

Abstract: The present invention provides devices and methods that can prevent or ameliorate bronchoconstriction by stimulating neural activity, in contrast to those techniques based on denervation, ablation or blocking of neural activity. Methods and devices according to the invention may act responsively or on demand, can preserve neuronal structure and function and will be associated with minimal collateral side-effects. In particular, the invention provides devices and methods in which signals are delivered to the vagus nerve in order to stimulate neural activity in the vagal nerve.

公开(公告)号：US20220054838A1

公开(公告)日：2022-02-24

申请号：US17415641

申请日：2019-12-13

Applicant: Galvani Bioelectronics Limited ,  The Trustees of Indiana University

Inventor： Michael John Carr ,  Rizwan Bashirullah ,  Kenichi Yoshida

IPC: A61N1/36

Abstract: An implantable neurostimulation system comprises at least one neural interface device for stimulating and/or inhibiting neural activity in a nerve such as the cervical vagus nerve. The device comprises first and second electrodes and at least one signal generator configured to generate first and second electrical signals that stimulate and/or inhibit neural activity in the nerve via the first and second electrodes. The first electrical signal is configured to stimulate neural activity in the nerve to cause at least one pre-determined physiological response; and the second electrical signal is configured to inhibit neural activity in the nerve to at least partially suppress the least one pre-determined physiological response.

公开(公告)号：US10441787B2

公开(公告)日：2019-10-15

申请号：US15552475

申请日：2016-02-24

Applicant: GALVANI BIOELECTRONICS LIMITED ,  THE JOHNS HOPKINS UNIVERSITY

Inventor： Brendan J. Canning ,  Michael John Carr ,  Marian Kollarik

IPC: A61N1/36 ,  A61N1/05 ,  A61F7/00 ,  A61N1/20 ,  A61N5/06 ,  A61N7/00 ,  A61N5/067

Abstract: The invention provides devices and methods that can prevent or ameliorate bronchoconstriction. In particular, the invention provides devices and methods in which a signal is delivered to the vagus nerve or the pulmonary branches of the vagus nerves. The signal is able to treat bronchoconstriction and prevent and/or ameliorate bronchoconstriction.