-
1.发明申请公开(公告)号：US20060127950A1
公开(公告)日：2006-06-15
申请号：US11244826
申请日：2005-10-06
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
CPC分类号： G01N33/6851 , G01N33/66 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2400/10 , G16C20/20
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。
-
2.发明申请公开(公告)号：US20100144553A1
公开(公告)日：2010-06-10
申请号：US12623070
申请日：2009-11-20
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
IPC分类号： C40B40/12
CPC分类号： G01N33/6851 , G01N33/66 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2400/10 , G06F19/703
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。
-
3.发明申请公开(公告)号：US20120289415A1
公开(公告)日：2012-11-15
申请号：US13478662
申请日：2012-05-23
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
IPC分类号： C40B20/08
CPC分类号： G01N33/6851 , G01N33/66 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2400/10 , G16C20/20
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。
-
4.发明授权公开(公告)号：US08209132B2
公开(公告)日：2012-06-26
申请号：US12623070
申请日：2009-11-20
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
IPC分类号： G01N31/00
CPC分类号： G01N33/6851 , G01N33/66 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2400/10 , G06F19/703
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。
-
5.发明申请公开(公告)号：US20100136599A1
公开(公告)日：2010-06-03
申请号：US12574161
申请日：2009-10-06
申请人： Pankaj Gandhe , Sasi Raguram , Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Ram Sasisekharan
发明人： Pankaj Gandhe , Sasi Raguram , Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Ram Sasisekharan
IPC分类号： G01N33/53
CPC分类号： G01N33/6842 , G01N33/6803 , G01N33/6851 , G01N2400/10 , Y10T436/143333
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information regarding the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation on protein function. Such methods are also provided. Methods are also provided to assess protein production processes, to assess the purity of proteins produced, and to select proteins with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及对蛋白质上发现的碳水化合物如N-聚糖和O-聚糖的分析。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 关于聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化对蛋白质功能的影响的研究。 还提供了这样的方法。 还提供了评估蛋白质生产过程，评估产生的蛋白质的纯度和选择具有所需糖基化的蛋白质的方法。
-
6.发明申请公开(公告)号：US20060057638A1
公开(公告)日：2006-03-16
申请号：US11107982
申请日：2005-04-15
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
CPC分类号： G01N33/6842 , G01N33/6803 , G01N33/6851 , G01N2400/10 , Y10T436/143333
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information regarding the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation on protein function. Such methods are also provided. Methods are also provided to assess protein production processes, to assess the purity of proteins produced, and to select proteins with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及对蛋白质上发现的碳水化合物如N-聚糖和O-聚糖的分析。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 关于聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化对蛋白质功能的影响的研究。 还提供了这样的方法。 还提供了评估蛋白质生产过程，评估产生的蛋白质的纯度和选择具有所需糖基化的蛋白质的方法。
-
7.发明授权公开(公告)号：US08000904B2
公开(公告)日：2011-08-16
申请号：US12574161
申请日：2009-10-06
申请人： Nishla Keiser , Carlos Bosques , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram , Aravind Srinivasan
发明人： Nishla Keiser , Carlos Bosques , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram , Aravind Srinivasan
IPC分类号： G01N31/00
CPC分类号： G01N33/6842 , G01N33/6803 , G01N33/6851 , G01N2400/10 , Y10T436/143333
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information regarding the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation on protein function. Such methods are also provided. Methods are also provided to assess protein production processes, to assess the purity of proteins produced, and to select proteins with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及对蛋白质上发现的碳水化合物如N-聚糖和O-聚糖的分析。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 关于聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化对蛋白质功能的影响的研究。 还提供了这样的方法。 还提供了评估蛋白质生产过程，评估产生的蛋白质的纯度和选择具有所需糖基化的蛋白质的方法。
-
公开(公告)号：US20080071148A1
公开(公告)日：2008-03-20
申请号：US11732482
申请日：2007-04-03
申请人： Carlos Bosques , Ram Sasisekharan , Sasi Raguram
发明人： Carlos Bosques , Ram Sasisekharan , Sasi Raguram
CPC分类号： G01N33/57484 , G01N33/5308 , G01N33/57407 , G01N33/57434 , G01N33/6893 , G01N2440/38 , G01N2800/342
摘要： This invention relates, in part, to methods and products for the detection of cancer, such as prostate cancer or multiple myeloma. This invention also relates, in part, to methods and products for the detection of prostate disease, such as benign prostatic hyperplasia (BPH). This invention further relates, in part, to methods and products for the detection of specific glycans in one or more samples, such as, for example, methods whereby specific glycans are detected and their amounts analyzed. Such methods can be used to determine relative ratios and/or threshold values for the specific glycans described herein. The relative ratios and/or threshold values can be used in the methods provided.
摘要翻译： 本发明部分涉及用于检测癌症的方法和产品，例如前列腺癌或多发性骨髓瘤。 本发明还部分涉及前列腺疾病如良性前列腺增生症（BPH）的检测方法和产品。 本发明还部分涉及用于检测一个或多个样品中特定聚糖的方法和产品，例如，检测特异性聚糖并分析其量的方法。 这样的方法可用于确定本文所述的特定聚糖的相对比例和/或阈值。 相对比率和/或阈值可以在所提供的方法中使用。
-
9.发明申请ENGINEERED POLYPEPTIDE AGENTS FOR TARGETED BROAD SPECTRUM INFLUENZA NEUTRALIZATION 有权工程化聚氨酯试剂，用于定向广谱光谱荧光中和公开(公告)号：US20110201547A1
公开(公告)日：2011-08-18
申请号：US13015455
申请日：2011-01-27
申请人： Ram Sasisekharan , Karthik Viswanathan , Venkataramanan Soundararajan , Sasi Raguram , Viswanathan Sasisekharan
发明人： Ram Sasisekharan , Karthik Viswanathan , Venkataramanan Soundararajan , Sasi Raguram , Viswanathan Sasisekharan
CPC分类号： A61K38/162 , A61K9/0053 , A61K9/0073 , A61K38/00 , C07K14/001 , C07K14/005 , C12N7/00 , C12N2760/16122 , C12N2760/16133 , G01N33/56983 , G01N2333/11
摘要： The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (HA) polypeptides and/or HA receptors, and reagents and methods relating thereto. The present invention provides a system for analyzing interactions between infolds and the interaction partners that bind to them.
摘要翻译： 本发明提供用于广谱流感中和的新型药剂。 本发明提供通过结合流感病毒和/或血凝素（HA）多肽和/或HA受体来抑制流感感染的试剂，以及与其相关的试剂和方法。 本发明提供了一种用于分析信息与与之结合的交互伙伴之间的相互作用的系统。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.034 秒)
