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    Methods and products related to the improved analysis of carbohydrates
    1.
    发明申请
    Methods and products related to the improved analysis of carbohydrates 审中-公开
    与碳水化合物改进分析有关的方法和产品

    公开(公告)号：US20060127950A1

    公开(公告)日：2006-06-15

    申请号：US11244826

    申请日：2005-10-06

    申请人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    发明人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    IPC分类号： C40B40/10 ,  G01N33/53 ,  C12P21/06

    CPC分类号： G01N33/6851 ,  G01N33/66 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/6848 ,  G01N2400/10 ,  G16C20/20

    摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.

    摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。

    METHODS AND PRODUCTS RELATED TO THE IMPROVED ANALYSIS OF CARBOHYDRATES
    2.
    发明申请
    METHODS AND PRODUCTS RELATED TO THE IMPROVED ANALYSIS OF CARBOHYDRATES 有权
    与改进的碳水化合物分析相关的方法和产品

    公开(公告)号：US20100144553A1

    公开(公告)日：2010-06-10

    申请号：US12623070

    申请日：2009-11-20

    申请人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    发明人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    IPC分类号： C40B40/12

    CPC分类号： G01N33/6851 ,  G01N33/66 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/6848 ,  G01N2400/10 ,  G06F19/703

    摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.

    摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。

    METHODS AND PRODUCTS RELATED TO THE IMPROVED ANALYSIS OF CARBOHYDRATES
    3.
    发明申请
    METHODS AND PRODUCTS RELATED TO THE IMPROVED ANALYSIS OF CARBOHYDRATES 审中-公开
    与改进的碳水化合物分析相关的方法和产品

    公开(公告)号：US20120289415A1

    公开(公告)日：2012-11-15

    申请号：US13478662

    申请日：2012-05-23

    申请人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    发明人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    IPC分类号： C40B20/08

    CPC分类号： G01N33/6851 ,  G01N33/66 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/6848 ,  G01N2400/10 ,  G16C20/20

    摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.

    摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。

    Methods and products related to the improved analysis of carbohydrates
    4.
    发明授权
    Methods and products related to the improved analysis of carbohydrates 有权
    与碳水化合物改进分析有关的方法和产品

    公开(公告)号：US08209132B2

    公开(公告)日：2012-06-26

    申请号：US12623070

    申请日：2009-11-20

    申请人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    发明人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    IPC分类号： G01N31/00

    CPC分类号： G01N33/6851 ,  G01N33/66 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/6848 ,  G01N2400/10 ,  G06F19/703

    摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.

    摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。