公开(公告)号：US09345732B2

公开(公告)日：2016-05-24

申请号：US13510815

申请日：2009-11-19

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Venkateswara Rao Chirravuri ,  Sivaramakrishna Chillara

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Venkateswara Rao Chirravuri ,  Sivaramakrishna Chillara

IPC分类号： A61K36/185 ,  A61K36/67 ,  A61K36/16 ,  A61K36/58 ,  A23L1/30

CPC分类号： A61K36/185 ,  A23L33/105 ,  A61K2300/00

摘要： The invention discloses phytochemical agents derived from Holoptelea integrifolia and novel composition(s) comprising at least one component selected from the extract(s), fraction(s) and active compound(s) for the protection and alleviation of Metabolic Syndrome, insulin resistance, endothelial dysfunction, chronic kidney disease, atherosclerosis, diabetes and other disease conditions associated with metabolic syndrome. The invention also discloses the amelioration of certain biomarker molecules such as Peroxisome proliferator-activated receptor gamma (PPAR-γ), Adipose Differentiation Related Protein (ADRP), CD36, Adipocyte Fatty-acid-Binding Protein (aP2/FABP-4/A-FABP), beta-3 Adrenergic Receptor (β3AR), Leptin, Perilipin and Adiponectin by using the phytochemical components derived from Holoptelea integrifolia.

摘要翻译： 本发明公开了源自全息莲的植物化学试剂和包含至少一种选自提取物，级分和活性化合物的组分的新组合物，用于保护和减轻代谢综合征，胰岛素抵抗， 内皮功能障碍，慢性肾脏疾病，动脉粥样硬化，糖尿病等与代谢综合征相关的疾病。 本发明还公开了一些生物标记分子的改进，例如过氧化物酶体增殖物激活受体γ（PPAR-γ），脂肪分化相关蛋白（ADRP），CD36，脂肪细胞脂肪酸结合蛋白（aP2 / FABP-4 / A- FABP），β-3肾上腺素能受体（＆bgr; 3AR），瘦蛋白，Perilipin和脂连蛋白，通过使用源自全息莲的植物化学成分。

公开(公告)号：US09241964B2

公开(公告)日：2016-01-26

申请号：US13146965

申请日：2010-02-01

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Krishanu Sengupta ,  Venkata Krishna Raju Alluri

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Krishanu Sengupta ,  Venkata Krishna Raju Alluri

IPC分类号： A61K36/00 ,  A61K36/28 ,  A23L1/30 ,  A61K36/38

CPC分类号： A61K36/38 ,  A23L33/105 ,  A23V2002/00 ,  A61K35/12 ,  A61K36/28 ,  A61K2300/00 ,  A23V2250/21

摘要： The invention relates pharmaceutical/dietary supplement/food ingredient(s) selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Sphaeranthus indicus and their compositions, preferably in combination with at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Garcinia mangostana. The ingredients and the composition(s) can be used for the control, prevention and treatment of obesity, metabolic syndrome, diabetes and other metabolic disorders, and also to regulate energy expenditure, prevention of atherosclerotic plaques in coronary artery and abdominal aorta, increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals.

摘要翻译： 本发明涉及选自提取物，级分，活性化合物和植物化学物质的衍生自Sphaeranthus indicus及其组合物的药物/膳食补充剂/食物成分，优选组合 与至少一种选自提取物，级分，活性化合物和植物化学物质的组分或其混合物衍生自芒of藤（Garcinia mangostana）。 成分和组成可用于控制，预防和治疗肥胖症，代谢综合征，糖尿病和其他代谢紊乱，并且还调节能量消耗，预防冠状动脉和腹主动脉中的动脉粥样硬化斑块，增加胰岛素 敏感性，改善葡萄糖耐量，降低甘油三酯水平和平衡哺乳动物中的葡萄糖水平。

公开(公告)号：US09427425B2

公开(公告)日：2016-08-30

申请号：US13450124

申请日：2012-04-18

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Krishanu Sengupta ,  Kiran Bhupathiraju

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Krishanu Sengupta ,  Kiran Bhupathiraju

IPC分类号： A61K31/365 ,  A61K36/324 ,  A61K36/61 ,  A61K36/9066 ,  A61K31/7008 ,  A61K9/22 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P7/00 ,  A61K36/185

CPC分类号： A61K31/365 ,  A61K36/185 ,  A61K2300/00

摘要： The current disclosure discloses acetogenin(s), extract(s)/fraction(s) standardized to acetogenin(s) comprising terminal α,β-unsaturated-γ-methyl-γ-lactone moiety derived from Annona squamosa or their compositions for prevention, treatment, inhibition or controlling inflammation and immune related diseases or disorders mediated through cytokines/chemokines or other biomarkers. The disclosure further discloses said Annona squamosa derived acetogenin(s), extract(s)/fraction(s) or their compositions for prevention, treatment, inhibition or controlling metabolic diseases/disorders.

摘要翻译： 目前的公开内容公开了丙酮佐剂，标准化为乙酰头发菌素的提取物/级分，其包含源自Annona squamosa的末端α，β-不饱和-γ-甲基-γ-内酯部分或其预防组合物， 治疗，抑制或控制通过细胞因子/趋化因子或其他生物标志物介导的炎症和免疫相关疾病或病症。 本公开进一步公开了所述Annona squamosa衍生的乙酰放大素，提取物/级分或其用于预防，治疗，抑制或控制代谢性疾病/病症的组合物。

公开(公告)号：US08828377B2

公开(公告)日：2014-09-09

申请号：US13616283

申请日：2012-09-14

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Venkata Krishna Raju Alluri

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Venkata Krishna Raju Alluri

IPC分类号： A01N63/00 ,  A61K36/00 ,  A61K36/324 ,  A61K35/60

CPC分类号： A61K36/324 ,  A61K31/12 ,  A61K31/56 ,  A61K35/60 ,  A61K36/28 ,  A61K36/38 ,  A61K36/68 ,  A61K36/9066 ,  A61K45/06 ,  A61K2300/00

摘要： The present disclosure relates to non-acidic extracts or fractions selected from a Boswellia low polar gum resin extract fraction (BLPRE), a Boswellia volatile oil fraction (BVOIL), and a Boswellia oil fraction (BOIL) and their compositions. BLPRE, BOIL, and BVOIL are each derived from the gum resin of a Boswellia species. These compositions are useful for improving mental condition, enhancing brain functions such as cognition, memory, learning, communication and brain health, for treating impaired memory, and for preventing, control or treating memory and cognition related disorders/diseases. Additionally, BOIL, BVOIL, and mixtures of BOIL and BVOIL are useful for enhancing the bioavailability of a biological agent.

摘要翻译： 本公开内容涉及选自下述的非酸性提取物或选自低密度脂蛋白树脂提取物级分（BLPRE），乳香型挥发油馏分（BVOIL）和乳香型油馏分（BOIL）及其组合物的级分。 BLPRE，BOIL和BVOIL各自衍生自Boswellia物种的树胶。 这些组合物可用于改善精神状况，增强脑功能，例如认知，记忆，学习，沟通和脑健康，用于治疗受损的记忆，以及预防，控制或治疗记忆和认知相关疾病/疾病。 另外，BOIL，BVOIL以及BOIL和BVOIL的混合物可用于增强生物制剂的生物利用度。

公开(公告)号：US20110280951A1

公开(公告)日：2011-11-17

申请号：US13146965

申请日：2009-02-02

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Krishanu Sengupta ,  Venkata Krishna Raju Alluri

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Krishanu Sengupta ,  Venkata Krishna Raju Alluri

IPC分类号： A61K35/12 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/10 ,  A61P35/00 ,  A61P25/00 ,  A61P25/28 ,  A61P17/00 ,  A61P9/12 ,  A61P3/06 ,  A61P37/00 ,  A61K36/00 ,  A61P9/00

CPC分类号： A61K31/365 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/19 ,  A61K31/352 ,  A61K31/437 ,  A61K31/5377 ,  A61K35/12 ,  A61K36/28 ,  A61K36/38 ,  A61K45/06 ,  A61K2300/00 ,  A23V2250/21

摘要： The invention relates pharmaceutical/dietary supplement/food ingredient(s) selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Sphaeranthus indicus and their compositions, preferably in combination with at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Garcinia mangostana. The ingredients and the composition(s) can be used for the control, prevention and treatment of obesity, metabolic syndrome, diabetes and other metabolic disorders, and also to regulate energy expenditure, prevention of atherosclerotic plaques in coronary artery and abdominal aorta, increase insulin sensitivity, prove glucose tolerance, lower triglyceride levels and balance glucose levels in mammals.

摘要翻译： 本发明涉及选自提取物，级分，活性化合物和植物化学物质的衍生自Sphaeranthus indicus及其组合物的药物/膳食补充剂/食物成分，优选组合 与至少一种选自提取物，级分，活性化合物和植物化学物质的组分或其混合物衍生自芒of藤（Garcinia mangostana）。 成分和组成可用于控制，预防和治疗肥胖症，代谢综合征，糖尿病和其他代谢紊乱，并且还调节能量消耗，预防冠状动脉和腹主动脉中的动脉粥样硬化斑块，增加胰岛素 敏感性，证明葡萄糖耐量，降低甘油三酯水平和平衡哺乳动物的葡萄糖水平。

公开(公告)号：US20120301432A1

公开(公告)日：2012-11-29

申请号：US13584099

申请日：2012-08-13

申请人： Ganga Raju GOKARAJU ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju

发明人： Ganga Raju GOKARAJU ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju

IPC分类号： A61K36/324 ,  A61P29/00 ,  A61K38/43 ,  A61K35/66 ,  A61K36/9066 ,  A61K35/60

CPC分类号： A61K36/324 ,  A61K31/12 ,  A61K31/19 ,  A61K31/215 ,  A61K2300/00

摘要： The present disclosure describes Boswellia low polar gum resin extract (BLPRE) comprising novel phytochemical composition of sesquiterpenes, diterpenes, triterpenes and other phytochemical(s) obtained from gum resin of Boswellia species. The present disclosure also describes compositions comprising BLPRE in combination with one or more component(s) selected from biologically active ingredient(s), functional ingredient(s), excipient(s), diluents(s), carrier(s) and additive(s) or mixtures thereof. Further the present disclosure also provides synergistic composition(s) comprising Boswellia low polar gum resin extract (BLPRE) and at least one component selected from but not limited to extract(s), fraction(s), phytochemical(s) or their salts or mixtures thereof derived from Boswellia species or Curcuma species.

摘要翻译： 本公开描述了含有由植物乳杆菌种的树胶获得的倍半萜烯，二萜烯，三萜烯和其它植物化学物质的新型植物化学成分的乳香低极性树胶树脂提取物（BLPRE）。 本公开还描述了包含BLPRE与选自生物活性成分，功能成分，赋形剂，稀释剂，载体和添加剂（一种或多种）的一种或多种组分的组合物， s）或其混合物。 此外，本公开还提供包含乳香低极性树胶树脂提取物（BLPRE）和至少一种选自但不限于提取物，级分，植物化学物质或其盐的组合物的协同组合物，或 其混合物衍生自乳香属物种或姜黄种。

公开(公告)号：US20100272678A1

公开(公告)日：2010-10-28

申请号：US12767647

申请日：2010-04-26

申请人： Ganga Raju GOKARAJU ,  Sudhakar Kasina ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Venkateswarlu Somepalli ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Sengupta Krishanu ,  Venkata Krishna Raju Alluri

发明人： Ganga Raju GOKARAJU ,  Sudhakar Kasina ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Venkateswarlu Somepalli ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Sengupta Krishanu ,  Venkata Krishna Raju Alluri

IPC分类号： A61K38/20 ,  C07C245/12 ,  A61K31/655 ,  A61K33/24 ,  A61K39/395 ,  A61K38/21 ,  A61K38/19 ,  A61P35/00

CPC分类号： A61K31/655 ,  A61K38/193 ,  A61K38/20 ,  A61K38/21 ,  A61K45/06 ,  C07D253/04 ,  C07D517/14 ,  A61K2300/00

摘要： Selenopheno triazene analogs, their compositions, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, and pharmaceutically acceptable salts and mixtures thereof are useful for the treatment of metastatic malignant melanoma and other cancers. The selenopheno triazene analogs have the general formulae (I) or (II): wherein the substituents R1, R2, R3, R6, and R7 are as described in the specification. Other cancers include which may be treated with these compounds include, but are not limited to, malignant melanoma, leukemia, lymphomas (Hodgkins and non-Hodgkins), sarcomas (Ewing's sarcoma), brain tumors, central nervous system (CNS) metastases, gliomas, carcinomas such as breast cancer, prostate cancer, lung cancer (small cell and non-small cell), colon cancer, pancreatic cancer, Head and Neck cancers and oropharyngeal squamous cell carcinoma.

摘要翻译： 硒代苯三氮烯类似物，它们的组合物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物及其药学上可接受的盐和混合物可用于治疗转移性恶性黑素瘤和其它癌症。 硒代苯并三氮烯类似物具有通式（I）或（II）：其中取代基R 1，R 2，R 3，R 6和R 7如说明书中所述。 可以用这些化合物治疗的其它癌症包括但不限于恶性黑素瘤，白血病，淋巴瘤（霍奇金淋巴瘤和非霍奇金淋巴瘤），肉瘤（尤文氏肉瘤），脑肿瘤，中枢神经系统（CNS）转移瘤，胶质瘤 ，癌症如乳腺癌，前列腺癌，肺癌（小细胞和非小细胞），结肠癌，胰腺癌，头颈部癌症和口咽鳞状细胞癌。

公开(公告)号：US09101599B2

公开(公告)日：2015-08-11

申请号：US13062066

申请日：2009-09-14

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Venkata Krishna Raju Alluri

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Venkata Krishna Raju Alluri

IPC分类号： A61K36/324

CPC分类号： A61K36/324

摘要： The present invention discloses synergistic nutraceutical or pharmaceutical or dietary supplement anti-inflammatory compositions comprising therapeutically effective combination of an extract selectively enriched in 3-O-acetyl-11-keto-β-boswellic acid (AKBA) derived from Boswellia serrata and Boswellia serrata non- acidic resin extract (BNRE). The composition(s) can be used to prevent, control and treat inflammation and several inflammatory related diseases including asthma, osteoarthritis, rheumatoid arthritis, endothelial dysfunction and the like. The invention further discloses the amelioration of pro-inflammator biomarker proteins or molecules, whose expression/production is altered during inflammatory diseases.

摘要翻译： 本发明公开了协同营养药物或药物或膳食补充剂抗炎组合物，其包含选自富含源于乳香乳杆菌（Boswellia serrata）和乳香型乳杆菌（Boswellia serrata）的3-O-乙酰基-11-酮 - 巴豆酸（AKBA） 非酸性树脂提取物（BNRE）。 组合物可用于预防，控制和治疗炎症和若干炎性相关疾病，包括哮喘，骨关节炎，类风湿性关节炎，内皮功能障碍等。 本发明还公开了改善炎症性疾病期间其表达/产生被改变的促炎剂生物标记蛋白或分子。

公开(公告)号：US08703215B2

公开(公告)日：2014-04-22

申请号：US13364717

申请日：2012-02-02

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Krishanu Sengupta ,  Kiran Bhupathiraju

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Krishanu Sengupta ,  Kiran Bhupathiraju

IPC分类号： A61K36/00

CPC分类号： A61K36/60

摘要： The invention discloses herbal ingredient(s) derived from Ficus hispida comprising herb powder(s), extract(s), fraction(s), pure compound(s) or mixtures thereof and their compositions for alleviating metabolic disorders selected from metabolic syndrome, obesity, diabetes, atherosclerosis, endothelial dysfunction and other metabolic disorders or conditions; the for amelioration of different biological marker proteins and metabolic processes associated metabolic disorders.

摘要翻译： 本发明公开了衍生自包含草药粉末，提取物，级分，纯化合物或其混合物的榕属植物的草药成分及其用于减轻选自代谢综合征，肥胖症的代谢紊乱的组合物 ，糖尿病，动脉粥样硬化，内皮功能障碍等代谢紊乱或病症; 用于改善不同生物标记蛋白和与代谢紊乱相关的代谢过程。

公开(公告)号：US20120231095A1

公开(公告)日：2012-09-13

申请号：US13510815

申请日：2009-11-19

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Venkateswara Rao Chirravuri ,  Sivaramakrishna Chillara

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Venkateswara Rao Chirravuri ,  Sivaramakrishna Chillara

IPC分类号： A61K31/4458 ,  A61K31/52 ,  A61K31/4425 ,  A61K31/047 ,  A61K36/81 ,  A61K36/42 ,  A61K36/16 ,  A61K36/54 ,  A61K36/67 ,  A61K36/185 ,  A61K36/482 ,  A61P3/00 ,  A61P3/10 ,  A61P9/10 ,  A61P3/04 ,  A61P9/12 ,  A61P7/00 ,  A61P31/00 ,  A61P29/00 ,  A61P3/06 ,  G01N30/90 ,  A61K31/513

CPC分类号： A61K36/185 ,  A23L33/105 ,  A61K2300/00

摘要： The invention discloses phytochemical agents derived from Holoptelea integrifolia and novel composition(s) comprising at least one component selected from the extract(s), fraction(s) and active compound(s) for the protection and alleviation of Metabolic Syndrome, insulin resistance, endothelial dysfunction, chronic kidney disease, atherosclerosis, diabetes and other disease conditions associated with metabolic syndrome. The invention also discloses the amelioration of certain biomarker molecules such as Peroxisome proliferator-activated receptor gamma (PPAR-γ), Adipose Differentiation Related Protein (ADRP), CD36, Adipocyte Fatty-acid-Binding Protein (aP2/FABP-4/A-FABP), beta-3 Adrenergic Receptor (β3AR), Leptin, Perilipin and Adiponectin by using the phytochemical components derived from Holoptelea integrifolia.

摘要翻译： 本发明公开了源自全息莲的植物化学试剂和包含至少一种选自提取物，级分和活性化合物的组分的新组合物，用于保护和减轻代谢综合征，胰岛素抵抗， 内皮功能障碍，慢性肾脏疾病，动脉粥样硬化，糖尿病等与代谢综合征相关的疾病。 本发明还公开了一些生物标记分子的改进，例如过氧化物酶体增殖物激活受体γ（PPAR-γ），脂肪分化相关蛋白（ADRP），CD36，脂肪细胞脂肪酸结合蛋白（aP2 / FABP-4 / A- FABP），β-3肾上腺素能受体（＆bgr; 3AR），瘦蛋白，Perilipin和脂连蛋白，通过使用源自全息莲的植物化学成分。