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    Methods for inducing antigen-specific T cell tolerance
    5.
    发明申请
    Methods for inducing antigen-specific T cell tolerance 审中-公开
    诱导抗原特异性T细胞耐受的方法

    公开(公告)号：US20060222649A1

    公开(公告)日：2006-10-05

    申请号：US11405876

    申请日：2006-04-17

    申请人： Randolph Noelle ,  Teresa Foy ,  Fiona Durie

    发明人： Randolph Noelle ,  Teresa Foy ,  Fiona Durie

    IPC分类号： A61K39/395

    CPC分类号： C07K14/70578 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/57 ,  C07K16/2875 ,  C07K19/00 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2319/00 ,  G01N33/6854

    摘要： Methods for inducing antigen-specific T cell tolerance are disclosed. The methods involve contacting a T cell with: 1) a cell which presents antigen to the T cell, wherein a ligand on the cell interacts with a receptor on the surface of the T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor on the surface of the T cell which inhibits interaction of the ligand on the antigen presenting cell with the receptor on the T cell. In a preferred embodiment, the cell which presents antigen to the T cell is a B cell and the receptor on the surface of the T cell which mediates contact-dependent helper effector function is gp39. Preferably, the antagonist is an anti-gp39 antibody or a soluble gp39 ligand (e.g., soluble CD40). The methods of the invention can be used to induce T cell tolerance to a soluble antigen or to an allogeneic cell. The methods of the invention can also be used to induce tolerance in cases of bone marrow transplantation and other organ transplants and to inhibit graft-versus-host disease.

    摘要翻译： 公开了诱导抗原特异性T细胞耐受性的方法。 所述方法包括使T细胞接触：1）向T细胞呈递抗原的细胞，其中细胞上的配体与介导接触依赖性辅助效应子功能的T细胞表面上的受体相互作用; 和2）T细胞表面上的受体拮抗剂，其抑制抗原呈递细胞上的配体与T细胞上的受体的相互作用。 在优选的实施方案中，向T细胞呈递抗原的细胞是B细胞，介导接触依赖性辅助效应子功能的T细胞表面上的受体是gp39。 优选地，拮抗剂是抗gp39抗体或可溶性gp39配体（例如可溶性CD40）。 本发明的方法可用于诱导对可溶性抗原或同种异体细胞的T细胞耐受性。 本发明的方法还可用于在骨髓移植和其他器官移植的情况下诱导耐受性并抑制移植物抗宿主病。

    FLYING EFFECTS CHOREOGRAPHY SYSTEM
    6.
    发明申请
    FLYING EFFECTS CHOREOGRAPHY SYSTEM 有权
    飞行效应CHOREOGRAPHY系统

    公开(公告)号：US20120229474A1

    公开(公告)日：2012-09-13

    申请号：US13415370

    申请日：2012-03-08

    申请人： Teresa Foy ,  Joe McGeough ,  Matthew Bevacqua ,  Carroll R. Mayhew

    发明人： Teresa Foy ,  Joe McGeough ,  Matthew Bevacqua ,  Carroll R. Mayhew

    IPC分类号： G06T13/80

    CPC分类号： G06T13/80 ,  G06T13/20

    摘要： A flying effects choreography system provides visualizations of flying effects within a virtual environment. The system allows choreographers to define a sequence of waypoints that identify a path of motion. A physics engine of the system may then calculate position data for a performer or other element attached to a free-swinging pendulum cable, as the performer and pendulum cable move along the path of motion. In this manner, the position data describes the motion of the performer, including the pendulum effect or swing of the performer on the pendulum cable. The position data may be used to generate one or more visualizations that show the performer's motion, including the pendulum effect. The choreographer may review the visualizations and make modifications any number of times, until a desired flying effect is produced, without having to physically implement the flying effect in the real world.

    摘要翻译： 飞行效果编排系统提供虚拟环境中飞行效果的可视化。 该系统允许编舞者定义标识运动路径的航路点序列。 系统的物理引擎可以随着演奏者和摆锤电缆沿着运动路径移动而计算表演者或连接到自由摆动摆绳索的其它元件的位置数据。 以这种方式，位置数据描述了表演者的运动，包括摆锤效应或演奏者在摆锤电缆上的摆动。 位置数据可以用于产生一个或多个显示执行者运动的可视化，包括摆锤效应。 编舞者可以检查可视化，并进行任何修改任何次数，直到产生所需的飞行效果，而无需在现实世界中实际实现飞行效果。

    Flying effects choreography system
    7.
    发明授权
    Flying effects choreography system 有权
    飞行效果编舞系统

    公开(公告)号：US09001130B2

    公开(公告)日：2015-04-07

    申请号：US13415370

    申请日：2012-03-08

    申请人： Teresa Foy ,  Joe McGeough ,  Matthew Bevacqua ,  Carroll R. Mayhew

    发明人： Teresa Foy ,  Joe McGeough ,  Matthew Bevacqua ,  Carroll R. Mayhew

    IPC分类号： G06T13/80 ,  G06T13/20

    CPC分类号： G06T13/80 ,  G06T13/20

    摘要： A flying effects choreography system provides visualizations of flying effects within a virtual environment. The system allows choreographers to define a sequence of waypoints that identify a path of motion. A physics engine of the system may then calculate position data for a performer or other element attached to a free-swinging pendulum cable, as the performer and pendulum cable move along the path of motion. In this manner, the position data describes the motion of the performer, including the pendulum effect or swing of the performer on the pendulum cable. The position data may be used to generate one or more visualizations that show the performer's motion, including the pendulum effect. The choreographer may review the visualizations and make modifications any number of times, until a desired flying effect is produced, without having to physically implement the flying effect in the real world.

    摘要翻译： 飞行效果编排系统提供虚拟环境中飞行效果的可视化。 该系统允许编舞者定义标识运动路径的航路点序列。 系统的物理引擎可以随着演奏者和摆锤电缆沿着运动路径移动而计算表演者或连接到自由摆动摆绳索的其它元件的位置数据。 以这种方式，位置数据描述了表演者的运动，包括摆锤效应或演奏者在摆锤电缆上的摆动。 位置数据可以用于产生一个或多个显示执行者运动的可视化，包括摆锤效应。 编舞者可以检查可视化，并进行任何修改任何次数，直到产生所需的飞行效果，而无需在现实世界中实际实现飞行效果。