专利检索 ap:("Gary J. Bridger" OR "Al Kaller" OR "Curtis Harwig" OR "Renato T. Skerlj" OR "David Bogucki" OR "Trevor R. Wilson" OR "Jason B. Crawford" OR "Ernest J. McEachern" OR "Bem Atsma" OR "Siqiao Nan" OR "Yuanxi Zhou" OR "Dominique Schols" OR "Christopher Dennis Smith" OR "Maria R. Di Fluri") AND inv:"Al Kaller" 第 1 页

1.

发明授权
Chemokine receptor binding heterocyclic compounds with enhanced efficacy 有权

公开(公告)号：US07354934B2

公开(公告)日：2008-04-08

申请号：US11301725

申请日：2005-12-13

申请人： Gary J. Bridger , Al Kaller , Curtis Harwig , Renato T. Skerlj , David Bogucki , Trevor R. Wilson , Jason B. Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria R. Di Fluri

发明人： Gary J. Bridger , Al Kaller , Curtis Harwig , Renato T. Skerlj , David Bogucki , Trevor R. Wilson , Jason B. Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria R. Di Fluri

IPC分类号： A61K31/4709 , C07D403/12

CPC分类号： C07D401/14 , C07D235/14 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/06 , C07D491/04

摘要： The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).

2.

发明申请
CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY 审中-公开
标题翻译：具有增强功效的化合物受体结合杂环化合物

公开(公告)号：US20080167341A1

公开(公告)日：2008-07-10

申请号：US12036187

申请日：2008-02-22

申请人： Gary BRIDGER , Renato T. Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason B. Crawford , Ernest J. Mceachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria R. Di Fluri

发明人： Gary BRIDGER , Renato T. Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason B. Crawford , Ernest J. Mceachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria R. Di Fluri

IPC分类号： A61K31/4709 , A61P7/00

CPC分类号： A61K31/4184 , A61K31/415 , A61K31/436 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/497 , A61K31/4985 , A61K31/50 , A61K31/502 , A61K31/506 , A61K31/5377 , C07D235/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04 , C07D471/06 , C07D491/04 , C07D491/052 , Y02A50/411

摘要： The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).

摘要翻译： 本发明涉及由三个侧基包围的核心氮原子组成的杂环化合物，其中三个侧基中的两个优选为苯并咪唑基甲基和四氢喹啉基，第三侧基含有N并且任选地含有另外的环。这些化合物与趋化因子受体结合，包括CXCR4和CCR5，并表现出针对人类免疫缺陷病毒（HIV）感染靶细胞的保护作用。

3.

发明授权
Chemokine receptor binding heterocyclic compounds with enhanced efficacy 有权
标题翻译：趋化因子受体结合杂环化合物具有增强的疗效

公开(公告)号：US08778967B2

公开(公告)日：2014-07-15

申请号：US13358041

申请日：2012-01-25

申请人： Gary Bridger , Renato T Skelj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R Wilson , Jason B Crawford , Ernest J McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria R Di Fluri

发明人： Gary Bridger , Renato T Skelj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R Wilson , Jason B Crawford , Ernest J McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria R Di Fluri

IPC分类号： A61K31/4709 , C07D403/12

CPC分类号： A61K31/4184 , A61K31/415 , A61K31/436 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/497 , A61K31/4985 , A61K31/50 , A61K31/502 , A61K31/506 , A61K31/5377 , C07D235/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04 , C07D471/06 , C07D491/04 , C07D491/052 , Y02A50/411

摘要： The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).

摘要翻译： 本发明涉及由三个侧基包围的核心氮原子组成的杂环化合物，其中三个侧基中的两个优选为苯并咪唑基甲基和四氢喹啉基，第三侧基含有N并且任选地含有另外的环。这些化合物与趋化因子受体结合，包括CXCR4和CCR5，并表现出针对人类免疫缺陷病毒（HIV）感染靶细胞的保护作用。

4.

发明授权
Chemokine receptor binding heterocyclic compounds 失效
标题翻译：趋化因子受体结合杂环化合物

公开(公告)号：US07183273B2

公开(公告)日：2007-02-27

申请号：US10837467

申请日：2004-04-30

申请人： Gary J. Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols

发明人： Gary J. Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols

IPC分类号： A61K31/55 , A61K31/47 , A61K31/445 , A61P19/02 , A61P31/18

CPC分类号： C07D239/42 , A61K45/06 , C07D213/38 , C07D215/40 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04

摘要： Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective against infection by HIV and exert effects characteristic of antagonists to the CXCR4 receptor.

摘要翻译： 公开了结合趋化因子受体并抑制其天然配体结合的杂环化合物。本发明化合物可防止HIV感染并发挥拮抗剂对CXCR4受体特征的作用。

5.

发明授权
Chemokine receptor binding heterocyclic compounds 失效

公开(公告)号：US07091217B2

公开(公告)日：2006-08-15

申请号：US10799386

申请日：2004-03-11

申请人： Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria Rosaria Di Fluri

发明人： Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria Rosaria Di Fluri

IPC分类号： A61K31/47 , C07D221/02

CPC分类号： C07D213/81 , A61K31/4709 , C07D213/38 , C07D213/65 , C07D215/40 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D493/04 , Y02A50/411

摘要： Compounds which modulate chemokine receptor activities are disclosed. These compounds are preferably tertiary amines comprising tetrahydroquinoline and benzimidazole.

6.

发明授权
Chemokine receptor binding heterocyclic compounds 失效
标题翻译：趋化因子受体结合杂环化合物

公开(公告)号：US07629337B2

公开(公告)日：2009-12-08

申请号：US11494943

申请日：2006-07-27

申请人： Gary J. Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols

发明人： Gary J. Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols

IPC分类号： C07D213/16 , C07D213/22 , A61K31/44 , A61K31/4427 , A61P19/02 , A61P31/18

CPC分类号： C07D239/42 , A61K45/06 , C07D213/38 , C07D215/40 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04

摘要： Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective against infection by HIV and exert effects characteristic of antagonists to the CXCR4 receptor.

摘要翻译： 公开了结合趋化因子受体并抑制其天然配体结合的杂环化合物。本发明化合物可防止HIV感染并发挥拮抗剂对CXCR4受体特征的作用。

7.

发明授权
Chemokine receptor binding heterocyclic compounds 失效
标题翻译：趋化因子受体结合杂环化合物

公开(公告)号：US07807694B2

公开(公告)日：2010-10-05

申请号：US11487038

申请日：2006-07-14

申请人： Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria Rosaria Di Fluri

发明人： Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria Rosaria Di Fluri

IPC分类号： A61K31/4709 , C07D403/12

CPC分类号： C07D213/81 , A61K31/4709 , C07D213/38 , C07D213/65 , C07D215/40 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D493/04 , Y02A50/411

摘要： Compounds which modulate chemokine receptor activities are disclosed. These compounds are preferably tertiary amines comprising tetrahydroquinoline and benzimidazole.

摘要翻译： 公开了调节趋化因子受体活性的化合物。这些化合物优选为包含四氢喹啉和苯并咪唑的叔胺。

8.

发明授权
Chemokine receptor binding heterocyclic compounds with enhanced efficacy 有权
标题翻译：趋化因子受体结合杂环化合物具有增强的疗效

公开(公告)号：US07354932B2

公开(公告)日：2008-04-08

申请号：US10457034

申请日：2003-06-06

申请人： Gary Bridger , Al Kaller , Curtis Harwig , Renato Skerlj , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria Rosaria Di Fluri

发明人： Gary Bridger , Al Kaller , Curtis Harwig , Renato Skerlj , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria Rosaria Di Fluri

IPC分类号： A61K31/4709 , C07D403/12

CPC分类号： A61K31/4184 , A61K31/415 , A61K31/436 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/497 , A61K31/4985 , A61K31/50 , A61K31/502 , A61K31/506 , A61K31/5377 , C07D235/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04 , C07D471/06 , C07D491/04 , C07D491/052 , Y02A50/411

摘要： The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).

摘要翻译： 本发明涉及由三个侧基包围的核心氮原子组成的杂环化合物，其中三个侧基中的两个优选为苯并咪唑基甲基和四氢喹啉基，第三侧基含有N并且任选地含有另外的环。这些化合物与趋化因子受体结合，包括CXCR4和CCR5，并表现出针对人类免疫缺陷病毒（HIV）感染靶细胞的保护作用。