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18 条记录 (耗时 0.027 秒)

    Flea protease proteins, nucleic acid molecules, and uses thereof
    2.
    发明授权
    Flea protease proteins, nucleic acid molecules, and uses thereof 失效
    跳蚤蛋白酶蛋白质，核酸分子及其用途

    公开(公告)号：US06210920B1

    公开(公告)日：2001-04-03

    申请号：US08749699

    申请日：1996-11-15

    申请人： Shirley Wu Hunter ,  Gary L. Stiegler ,  Patrick J. Gaines

    发明人： Shirley Wu Hunter ,  Gary L. Stiegler ,  Patrick J. Gaines

    IPC分类号： C12P2106

    CPC分类号： C12N9/6408 ,  A61K35/00 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4359 ,  C07K14/4742 ,  C07K16/18 ,  C07K16/40 ,  C07K2319/00 ,  C12N9/48 ,  C12N9/641 ,  C12N9/6424 ,  C12N9/6472 ,  Y10S530/858

    摘要： The present invention relates to flea serine protease proteins and flea cysteine protease proteins; to flea serine protease and cysteine protease nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease and/or cysteine protease activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.

    摘要翻译： 本发明涉及跳蚤丝氨酸蛋白酶蛋白和跳蚤半胱氨酸蛋白酶蛋白; 跳蚤丝氨酸蛋白酶和半胱氨酸蛋白酶核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶和/或半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物以及这种治疗组合物用于保护宿主动物免于跳蚤侵染的用途。

    Flea nucleic acid sequences and uses thereof
    4.
    发明授权
    Flea nucleic acid sequences and uses thereof 失效
    跳蚤核酸序列及其用途

    公开(公告)号：US5952194A

    公开(公告)日：1999-09-14

    申请号：US690849

    申请日：1996-08-01

    申请人： Gary L. Stiegler

    发明人： Gary L. Stiegler

    IPC分类号： A61K38/00 ,  C07K14/435 ,  C12N1/21 ,  C12N15/12

    CPC分类号： C07K14/4359 ,  C07K14/43563 ,  A61K38/00 ,  Y10S530/858

    摘要： The present invention relates to ectoparasite histamine releasing factor (HRF) proteins; to ectoparasite HRF nucleic acid molecules, including those that encode such HRF proteins; to antibodies raised against such HRF proteins; and to compounds that inhibit ectoparasite HRF activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to reduce ectoparasite burden of animals.

    摘要翻译： 本发明涉及外寄生物组胺释放因子（HRF）蛋白; 到外寄生物HRF核酸分子，包括编码这种HRF蛋白的那些; 针对这种HRF蛋白产生的抗体; 以及抑制外寄生物HRF活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及使用这种治疗组合物来减少动物的外寄生物负担。

    Ectoparasite histamine releasing factor, genes and uses thereof
    6.
    发明授权
    Ectoparasite histamine releasing factor, genes and uses thereof 失效
    外寄生物组胺释放因子，基因及其用途

    公开(公告)号：US6063902A

    公开(公告)日：2000-05-16

    申请号：US4053

    申请日：1998-01-07

    申请人： Gary L. Stiegler

    发明人： Gary L. Stiegler

    IPC分类号： A61K38/00 ,  C07K14/435 ,  C12N1/21 ,  C12N15/12 ,  C07K1/00 ,  A61K39/00 ,  C07K16/00 ,  A61K14/00

    CPC分类号： C07K14/4359 ,  C07K14/43563 ,  A61K38/00 ,  Y10S530/858

    摘要： The present invention relates to ectoparasite histamine releasing factor (HRF) proteins; to ectoparasite HRF nucleic acid molecules, including those that encode such HRF proteins; to antibodies raised against such HRF proteins; and to compounds that inhibit ectoparasite HRF activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to reduce ectoparasite burden of animals.

    摘要翻译： 本发明涉及外寄生物组胺释放因子（HRF）蛋白; 到外寄生物HRF核酸分子，包括编码这种HRF蛋白的那些; 针对这种HRF蛋白产生的抗体; 以及抑制外寄生物HRF活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及使用这种治疗组合物来减少动物的外寄生物负担。

    Flea protease proteins, nucleic acid molecules, and uses thereof
    8.
    发明授权
    Flea protease proteins, nucleic acid molecules, and uses thereof 失效
    跳蚤蛋白酶蛋白质，核酸分子及其用途

    公开(公告)号：US06204010B1

    公开(公告)日：2001-03-20

    申请号：US09032215

    申请日：1998-02-27

    申请人： Gary L. Stiegler ,  Patrick J. Gaines

    发明人： Gary L. Stiegler ,  Patrick J. Gaines

    IPC分类号： C12N1512

    CPC分类号： C12N9/6408 ,  A61K35/00 ,  A61K39/00 ,  C07K16/40 ,  C12N9/48 ,  C12N9/641 ,  C12N9/6424 ,  C12N9/6472

    摘要： The present invention relates to flea serine protease proteins; to flea serine protease nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.

    摘要翻译： 本发明涉及跳蚤丝氨酸蛋白酶蛋白质; 到跳蚤丝氨酸蛋白酶核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物以及这种治疗组合物用于保护宿主动物免于跳蚤侵染的用途。

    Methods of eliciting an antibody response using flea protease proteins and homologs thereof
    10.
    发明授权
    Methods of eliciting an antibody response using flea protease proteins and homologs thereof 失效
    使用跳蚤蛋白酶蛋白及其同源物引起抗体应答的方法

    公开(公告)号：US6139840A

    公开(公告)日：2000-10-31

    申请号：US817795

    申请日：1997-08-01

    申请人： Robert B. Grieve ,  Keith E. Rushlow ,  Shirley W. Hunter ,  Glenn R. Frank ,  Gary L. Stiegler

    发明人： Robert B. Grieve ,  Keith E. Rushlow ,  Shirley W. Hunter ,  Glenn R. Frank ,  Gary L. Stiegler

    IPC分类号： A61K35/00 ,  A61P33/00 ,  C07K16/40 ,  C12N9/48 ,  C12N9/64 ,  A61K39/00 ,  A61K38/48

    CPC分类号： C12N9/6424 ,  C07K16/40 ,  C12N9/48 ,  C12N9/6472 ,  A61K35/00

    摘要： The present invention relates to flea serine protease and aminopeptidase proteins; to flea serine protease and aminopeptidase nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease and/or aminopeptdiase activities. The present invention also includes methods to obtain such proteins, nucleic acid moelcules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.

    摘要翻译： PCT No.PCT / US95 / 14442 Sec。 371日期：1997年8月1日 102（e）日期1997年8月1日PCT提交1995年10月18日PCT公布。 公开号WO96 / 11706 日期1996年04月25日本发明涉及跳蚤丝氨酸蛋白酶和氨基肽酶蛋白质; 跳蚤丝氨酸蛋白酶和氨基肽酶核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶和/或氨基肽酶活性的化合物。 本发明还包括获得这样的蛋白质，核酸moelcules，抗体和抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物以及这种治疗组合物用于保护宿主动物免于跳蚤侵染的用途。