公开(公告)号：US5752925A

公开(公告)日：1998-05-19

申请号：US661976

申请日：1996-06-12

申请人： Gary S. Beaupre ,  Dennis R. Carter ,  Wilson C. Hayes

发明人： Gary S. Beaupre ,  Dennis R. Carter ,  Wilson C. Hayes

IPC分类号： A61H1/00 ,  A61N1/00

CPC分类号： A61H1/006

摘要： The invention presents a method and device for increasing the fracture resistance of a bone tissue to a traumatic force. The method includes the step of selecting a nonphysiological impulse force having a location and direction resembling that of the traumatic force, but having a magnitude significantly smaller than the magnitude of the traumatic force. The impulse force is then repeatedly applied to the bone tissue, thereby stimulating the bone tissue to grow bone mass in critical areas where stresses from the traumatic force are largest. A device for applying the method includes an impulse force applicator for repeatedly applying the impulse force and a positioner for positioning the impulse force relative to the bone tissue.

摘要翻译： 本发明提供了一种用于增加骨组织对创伤力的抗断裂性的方法和装置。 该方法包括选择具有与创伤力的位置和方向类似的位置和方向但具有显着小于创伤力的大小的量级的非生理冲动力的步骤。 然后将冲击力反复施加到骨组织，由此刺激骨组织在来自创伤力的应力最大的关键区域中生长骨量。 用于施加该方法的装置包括用于重复施加脉冲力的脉冲力施加器和用于相对于骨组织定位脉冲力的定位器。

公开(公告)号：US06528052B1

公开(公告)日：2003-03-04

申请号：US09677109

申请日：2000-09-29

申请人： R. Lane Smith ,  Dennis R. Carter ,  David J. Schurman

发明人： R. Lane Smith ,  Dennis R. Carter ,  David J. Schurman

IPC分类号： C12N500

CPC分类号： C12N5/0655 ,  A61F2/08 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2240/001 ,  A61F2310/00365 ,  A61K35/12 ,  A61K35/32 ,  C12N2500/02 ,  C12N2521/00

摘要： A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene, expression of growth factors that are inhibitory to type II collagen expression.

摘要翻译： 一种体内，体外和体外再生软骨和胶原蛋白的方法。 通过间歇施加的静水压力，体内，离体和体外再生和从头形成关节软骨和胶原。 外部间隔负荷的应用由反复施加的静水压力组成，随后由复原期间中断。 在生理水平5-10MPA下间歇4小时的间歇静水压力的应用，随后的恢复期直到约20小时，所述压力在体外施加于软骨细胞，体外离体外植体和体内至软体 在关节关节的关节间隙内保持完整的软骨。 间隔负荷导致基质降解酶，促炎细胞因子和趋化因子的选择性抑制，其吸引炎症细胞进入关节腔，并选择性降低基因，抑制II型胶原表达的生长因子的表达。

公开(公告)号：US08679190B2

公开(公告)日：2014-03-25

申请号：US13418294

申请日：2012-03-12

申请人： David Myung ,  Lampros Kourtis ,  Laura Hartmann ,  Curtis W. Frank ,  Stuart B. Goodman ,  Dennis R. Carter

发明人： David Myung ,  Lampros Kourtis ,  Laura Hartmann ,  Curtis W. Frank ,  Stuart B. Goodman ,  Dennis R. Carter

IPC分类号： A61F2/30

CPC分类号： A61F2/30756 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3603 ,  A61F2/3872 ,  A61F2/4202 ,  A61F2/4225 ,  A61F2/4241 ,  A61F2/4405 ,  A61F2002/30075 ,  A61F2002/30448 ,  A61F2002/30754 ,  A61F2002/3619 ,  A61F2210/0061 ,  A61F2220/005 ,  A61F2310/00293 ,  A61L27/18 ,  A61L27/34 ,  A61L27/3843 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/24

摘要： An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.

摘要翻译： 提供了一种具有互穿聚合物网络（IPN）水凝胶的关节成形术装置，其通过溶胀变形硬化并且适于通过符合骨几何形状在关节中保持就位。 应变硬化IPN水凝胶基于两个不同的网络：（1）通过其端基聚合化学交联的预先形成的亲水非离子遥爪大分子单体的非硅氧烷网络，和（2）非硅氧烷网络 的可离子化单体。 第二个网络在第一个网络的存在下被聚合和化学交联，并与第一个网络形成了物理交叉链路。 在IPN中，第二网络中的化学交联程度小于第一网络中的化学交联度。 使用盐水溶液（中性pH）来电离和膨胀第二网络。 第二个网络的肿胀受到第一个网络的限制，导致IPN内有效的物理交叉链路的增加。

公开(公告)号：US20120232657A1

公开(公告)日：2012-09-13

申请号：US13418294

申请日：2012-03-12

申请人： David Myung ,  Lampros Kourtis ,  Laura Hartmann ,  Curtis W. Frank ,  Stuart B. Goodman ,  Dennis R. Carter

发明人： David Myung ,  Lampros Kourtis ,  Laura Hartmann ,  Curtis W. Frank ,  Stuart B. Goodman ,  Dennis R. Carter

IPC分类号： A61F2/02

CPC分类号： A61F2/30756 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3603 ,  A61F2/3872 ,  A61F2/4202 ,  A61F2/4225 ,  A61F2/4241 ,  A61F2/4405 ,  A61F2002/30075 ,  A61F2002/30448 ,  A61F2002/30754 ,  A61F2002/3619 ,  A61F2210/0061 ,  A61F2220/005 ,  A61F2310/00293 ,  A61L27/18 ,  A61L27/34 ,  A61L27/3843 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/24

摘要： An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.

摘要翻译： 提供了一种具有互穿聚合物网络（IPN）水凝胶的关节成形术装置，其通过溶胀变形硬化并且适于通过符合骨几何形状在关节中保持就位。 应变硬化IPN水凝胶基于两个不同的网络：（1）通过其端基聚合化学交联的预先形成的亲水非离子遥爪大分子单体的非硅氧烷网络，和（2）非硅氧烷网络 的可离子化单体。 第二个网络在第一个网络的存在下被聚合和化学交联，并与第一个网络形成了物理交叉链路。 在IPN中，第二网络中的化学交联程度小于第一网络中的化学交联度。 使用盐水溶液（中性pH）来电离和膨胀第二网络。 第二个网络的肿胀受到第一个网络的限制，导致IPN内有效的物理交叉链路的增加。

公开(公告)号：US20090176304A1

公开(公告)日：2009-07-09

申请号：US11980967

申请日：2008-07-11

申请人： R. Lane Smith ,  Dennis R. Carter ,  David J. Schurman

发明人： R. Lane Smith ,  Dennis R. Carter ,  David J. Schurman

IPC分类号： C12N5/08 ,  C12N5/06

CPC分类号： C12N5/0655 ,  A61F2/08 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2240/001 ,  A61F2310/00365 ,  A61K35/12 ,  A61K35/32 ,  C12N2500/02 ,  C12N2521/00

摘要： A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene expression of growth factors that are inhibitory to type II collagen expression.

摘要翻译： 一种体内，体外和体外再生软骨和胶原蛋白的方法。 通过间歇施加的静水压力，体内，离体和体外再生和从头形成关节软骨和胶原。 外部间隔负荷的应用由反复施加的静水压力组成，随后由复原期间中断。 在生理水平5-10MPA下间歇4小时的间歇静水压力的应用，随后的恢复期直到约20小时，所述压力在体外施加于软骨细胞，体外离体外植体和体内至软体 在关节关节的关节间隙内保持完整的软骨。 间隔负荷导致基质降解酶，促炎细胞因子和趋化因子的选择性抑制，其吸引炎症细胞进入关节腔，并选择性降低抑制II型胶原表达的生长因子的基因表达。

公开(公告)号：US20090088846A1

公开(公告)日：2009-04-02

申请号：US12148534

申请日：2008-04-17

申请人： David Myung ,  Lampros Kourtis ,  Laura Hartmann ,  Curtis W. Frank ,  Stuart B. Goodman ,  Dennis R. Carter

发明人： David Myung ,  Lampros Kourtis ,  Laura Hartmann ,  Curtis W. Frank ,  Stuart B. Goodman ,  Dennis R. Carter

IPC分类号： A61F2/08

CPC分类号： A61F2/30756 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3603 ,  A61F2/3872 ,  A61F2/4202 ,  A61F2/4225 ,  A61F2/4241 ,  A61F2/4405 ,  A61F2002/30075 ,  A61F2002/30448 ,  A61F2002/30754 ,  A61F2002/3619 ,  A61F2210/0061 ,  A61F2220/005 ,  A61F2310/00293 ,  A61L27/18 ,  A61L27/34 ,  A61L27/3843 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/24

摘要： An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.

摘要翻译： 提供了一种具有互穿聚合物网络（IPN）水凝胶的关节成形术装置，其通过溶胀变形硬化并且适于通过符合骨几何形状在关节中保持就位。 应变硬化IPN水凝胶基于两个不同的网络：（1）通过其端基聚合化学交联的预先形成的亲水非离子遥爪大分子单体的非硅氧烷网络，和（2）非硅氧烷网络 的可离子化单体。 第二个网络在第一个网络的存在下被聚合和化学交联，并与第一个网络形成了物理交叉链路。 在IPN中，第二网络中的化学交联程度小于第一网络中的化学交联度。 使用盐水溶液（中性pH）来电离和膨胀第二网络。 第二个网络的肿胀受到第一个网络的限制，导致IPN内有效的物理交叉链路的增加。

公开(公告)号：US4683878A

公开(公告)日：1987-08-04

申请号：US728185

申请日：1985-04-29

申请人： Dennis R. Carter

发明人： Dennis R. Carter

IPC分类号： A61B17/80 ,  A61F5/04

CPC分类号： A61B17/8014

摘要： The present invention comprises an elongated bone fixation plate with a center portion which bridges the fracture site. The central portion has a square cross-sectional shape. Two oppositely directed end portions extend axially from the central portion. The central portion has a width which is substantially less than the width of the end portions of the bone fixation plate. The end portions of the bone fixation plate have a plurality of elongated holes and each end portion tapers in thickness from adjacent the central portion to the outer terminating ends of the fixation plate. The plurality of holes are elongated in nature with each hole having a vertical distal wall and an inclined proximal end wall sloping toward the vertical distal wall. Each end portion has a uniform width and the entire bottom surface of each end portion may be concave in shape so as to provide a complementary mating surface with the fractured bone. By employing cortical or cancellous bone screws having a head whose bottom surface is rounded, the bone fixation plate draws each bone piece toward one another and places the bone pieces in compression at the fracture site when the plate and screws are fully secured to the bone.

摘要翻译： 本发明包括具有桥接断裂部位的中心部分的细长骨固定板。 中心部分具有正方形横截面形状。 两个相对定向的端部从中心部分轴向延伸。 中心部分的宽度大致小于骨固定板端部的宽度。 骨固定板的端部具有多个细长孔，并且每个端部从邻近固定板的中心部分到外部终端的厚度逐渐变细。 多个孔本质上是细长的，每个孔具有垂直的远侧壁和朝向垂直远端壁倾斜的倾斜近端壁。 每个端部具有均匀的宽度，并且每个端部的整个底表面的形状可以是凹形的，以便提供与断裂骨骼的互补配合表面。 通过使用具有底部表面为圆形的头部的皮质或松质骨螺钉，当固定板和螺钉完全固定到骨骼上时，骨固定板将每个骨块彼此朝向彼此并且将骨块压缩在骨折部位。

公开(公告)号：US07892799B2

公开(公告)日：2011-02-22

申请号：US11897911

申请日：2007-08-30

申请人： Robert Lane Smith ,  Dennis R. Carter ,  David J. Schurman

发明人： Robert Lane Smith ,  Dennis R. Carter ,  David J. Schurman

IPC分类号： C12N5/00

CPC分类号： C12N5/0655 ,  A61F2/08 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2240/001 ,  A61F2310/00365 ,  A61K35/12 ,  A61K35/32 ,  C12N2500/02 ,  C12N2521/00

摘要： A method for in vivo, ex vivo and in vitro regeneration of cartilage, collagen and bone remodeling by intermittently applied hydrostatic pressure consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The intermittent hydrostatic pressure is applied at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene expression of growth factors that are inhibitory to type II collagen expression.

摘要翻译： 一种通过间歇性施加的静水压力的体内，体外和体外再生软骨，胶原和骨重建的方法，所述静态压力由重复的施加的静水压力周期组成，并在恢复期后中断。 间歇静水压力以生理水平5-10MPA施用，间隔4小时，随后的恢复时间长达约20小时。 间隔负荷导致基质降解酶，促炎细胞因子和趋化因子的选择性抑制，其吸引炎症细胞进入关节腔，并选择性降低抑制II型胶原表达的生长因子的基因表达。

公开(公告)号：US06383226B1

公开(公告)日：2002-05-07

申请号：US09094230

申请日：1998-06-09

申请人： Dennis R. Carter ,  Jay A. Mandell ,  Gary S. Beaupré ,  David J. Schurman

发明人： Dennis R. Carter ,  Jay A. Mandell ,  Gary S. Beaupré ,  David J. Schurman

IPC分类号： A61F236

CPC分类号： A61F2/3609 ,  A61F2/0095 ,  A61F2/30767 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3662 ,  A61F2/40 ,  A61F2/4014 ,  A61F2/4059 ,  A61F2002/30004 ,  A61F2002/30112 ,  A61F2002/3021 ,  A61F2002/30604 ,  A61F2002/30616 ,  A61F2002/307 ,  A61F2002/3071 ,  A61F2002/30729 ,  A61F2002/3611 ,  A61F2002/3625 ,  A61F2002/3631 ,  A61F2002/4018 ,  A61F2002/4029 ,  A61F2002/4033 ,  A61F2002/4631 ,  A61F2230/0004 ,  A61F2230/0067 ,  A61F2250/0014 ,  A61F2250/0064 ,  A61F2250/0081 ,  A61F2250/0085 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00179 ,  A61F2310/00796

摘要： Novel prostheses, particularly femoral prostheses, are provided. The subject devices are characterized by the presence of a curvilinear collar. Also provided are methods of implanting a prosthesis in a manner sufficient to provide for a pressure profile at the collar interface in which the pressure increases from the endosteal to the periosteal surface of the bone.

摘要翻译： 提供新型假体，特别是股骨假体。 主题装置的特征在于存在曲线领。 还提供了以足够的方式植入假体的方法，所述方式足以提供在颈部界面处的压力分布，其中压力从骨的内膜到骨膜表面增加。