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公开(公告)号：USD646778S1
公开(公告)日：2011-10-11
申请号：US29388118
申请日：2011-03-24
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公开(公告)号：USD655806S1
公开(公告)日：2012-03-13
申请号：US29388166
申请日：2011-03-24
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公开(公告)号：USD743533S1
公开(公告)日：2015-11-17
申请号：US29388210
申请日：2011-03-25
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公开(公告)号：US20100264090A1
公开(公告)日：2010-10-21
申请号：US12601772
申请日：2008-05-29
申请人： Darren Ellis , Tine Borgen Hildisch , Jez Mundy , Erlend Ragnhildstveit , Richard Johan Toften , Kornelija Zgonc , Malin Karlson , Gaute Brede , Lars Nokleby
发明人： Darren Ellis , Tine Borgen Hildisch , Jez Mundy , Erlend Ragnhildstveit , Richard Johan Toften , Kornelija Zgonc , Malin Karlson , Gaute Brede , Lars Nokleby
IPC分类号： B03C1/031
CPC分类号： B03C1/288 , B01L9/06 , B03C1/0332 , B03C2201/18 , B03C2201/26
摘要： The present disclosure relates to a magnetising portion for providing a high-gradient magnetic field in a magnetic separation device. The magnetising portion comprises at least one magnetic assembly. The at least one magnetic assembly comprises: a plurality of magnets whereby each magnet has a north pole, south pole and a magnet axis extending between the north and south poles, and the plurality of magnets are arranged one above the other in a direction at least substantially perpendicular to the axis of each magnet in such a manner that the north and south poles of adjacent magnets are arranged alternately and a space is provide between adjacent magnets; and at least one non-magnetic spacing means arranged in the space between adjacent magnets. The present disclosure also relates to magnetic separation devices comprising at least one of the said magnetising portions and to a method of isolating magnetically labelled particles using the magnetic separation devices.
摘要翻译： 本公开涉及一种用于在磁选机中提供高梯度磁场的磁化部分。 磁化部分包括至少一个磁性组件。 所述至少一个磁性组件包括：多个磁体，其中每个磁体具有北极，南极和在所述北极和南极之间延伸的磁体轴线，并且所述多个磁体在至少一个方向上彼此上下排列 基本上垂直于每个磁体的轴线，使得相邻磁体的北极和南极交替布置并且在相邻磁体之间提供空间; 以及布置在相邻磁体之间的空间中的至少一个非磁性间隔装置。 本公开还涉及包括至少一个所述磁化部分的磁分离装置以及使用磁分离装置分离磁性标记颗粒的方法。
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公开(公告)号：US20110198293A1
公开(公告)日：2011-08-18
申请号：US12601783
申请日：2008-05-29
申请人： Darren Ellis , Tine Borgen Hildisch , Jeremy Mundy , Erlend Ragnhildstveit , Richard Johan Toften , Kornelija Zgonc , Gaute Brede , Lars Nokleby
发明人： Darren Ellis , Tine Borgen Hildisch , Jeremy Mundy , Erlend Ragnhildstveit , Richard Johan Toften , Kornelija Zgonc , Gaute Brede , Lars Nokleby
IPC分类号： B01D35/06
CPC分类号： B03C1/288 , B01L9/06 , B03C1/0332 , B03C2201/18 , B03C2201/26
摘要： The disclosure relates to a magnetic separating device for isolating magnetically labelled particles from a non-magnetic medium comprising a body portion (1) having a magnetising portion (3) for providing a magnetic field and a surface by means of which the body portion may stand on a supporting surface; and a sample vessel retaining portion (4) for retaining at least one sample vessel (5), wherein, the magnetising portion (3) is configured to conform at least approximately to at least a substantial portion of the longitudinal profile of at least one sample vessel (5); the sample vessel retaining portion (4) is configured to retain at least one sample vessel (5) such that at least a portion of the contents of the sample vessel (5) is visible to a user; and the sample vessel retaining portion (4) is configured to be mountable on the magnetising portion so that in use, the at least one sample vessel is subject to the magnetic field of the magnetising portion (3). The disclosure further relates to a kit of parts and a method for isolating magnetically labelled particles from a non-magnetic medium using the magnetic separation device.
摘要翻译： 本公开涉及一种用于从非磁性介质中分离磁性标记的颗粒的磁分离装置，其包括具有用于提供磁场的磁化部分（3）的主体部分（1）和主体部分可以通过该磁体表面 在支撑面上 以及用于保持至少一个样品容器（5）的样品容器保持部分（4），其中，所述磁化部分（3）构造成使至少大致至少大致至少一部分至少一个样品的纵向轮廓 船只（5）; 样品容器保持部分（4）构造成保持至少一个样品容器（5），使得样品容器（5）的内容物的至少一部分对使用者是可见的; 并且样品容器保持部（4）被构造成可安装在磁化部分上，使得在使用中，至少一个样品容器受到磁化部分（3）的磁场的影响。 本发明还涉及使用磁选机从非磁性介质中分离磁性标记的颗粒的一组零件和方法。
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公开(公告)号：USD637709S1
公开(公告)日：2011-05-10
申请号：US29305042
申请日：2008-03-12
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公开(公告)号：US09227199B2
公开(公告)日：2016-01-05
申请号：US12601772
申请日：2008-05-29
申请人： Darren Ellis , Tine Borgen Hildisch , Jeremy Mundy , Erlend Ragnhildstveit , Richard Johan Toften , Kornelija Zgonc , Malin Karlsson , Gaute Brede , Lars Noekleby
发明人： Darren Ellis , Tine Borgen Hildisch , Jeremy Mundy , Erlend Ragnhildstveit , Richard Johan Toften , Kornelija Zgonc , Malin Karlsson , Gaute Brede , Lars Noekleby
CPC分类号： B03C1/288 , B01L9/06 , B03C1/0332 , B03C2201/18 , B03C2201/26
摘要： The present disclosure relates to a magnetizing portion for providing a high-gradient magnetic field in a magnetic separation device. The magnetizing portion comprises at least one magnetic assembly. The at least one magnetic assembly comprises: a plurality of magnets whereby each magnet has a north pole, south pole and a magnet axis extending between the north and south poles, and the plurality of magnets are arranged one above the other in a direction at least substantially perpendicular to the axis of each magnet in such a manner that the north and south poles of adjacent magnets are arranged alternately and a space is provide between adjacent magnets; and at least one non-magnetic spacing means arranged in the space between adjacent magnets. The present disclosure also relates to magnetic separation devices comprising at least one of the said magnetizing portions and to a method of isolating magnetically labelled particles using the magnetic separation devices.
摘要翻译： 本公开涉及一种用于在磁选机中提供高梯度磁场的磁化部分。 磁化部分包括至少一个磁性组件。 所述至少一个磁性组件包括：多个磁体，其中每个磁体具有北极，南极和在所述北极和南极之间延伸的磁体轴线，并且所述多个磁体在至少一个方向上彼此上下排列 基本上垂直于每个磁体的轴线，使得相邻磁体的北极和南极交替布置并且在相邻磁体之间提供空间; 以及布置在相邻磁体之间的空间中的至少一个非磁性间隔装置。 本公开还涉及包括所述磁化部分中的至少一个的磁分离装置以及使用磁分离装置分离磁性标记颗粒的方法。
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公开(公告)号：US08574515B2
公开(公告)日：2013-11-05
申请号：US12601783
申请日：2008-05-29
申请人： Darren Ellis , Tine Borgen Hildisch , Jeremy Mundy , Erlend Ragnhildstveit , Richard Johan Toften , Kornelija Zgonc , Gaute Brede , Lars Noekleby
发明人： Darren Ellis , Tine Borgen Hildisch , Jeremy Mundy , Erlend Ragnhildstveit , Richard Johan Toften , Kornelija Zgonc , Gaute Brede , Lars Noekleby
IPC分类号： B01D33/06
CPC分类号： B03C1/288 , B01L9/06 , B03C1/0332 , B03C2201/18 , B03C2201/26
摘要： The disclosure relates to a magnetic separating device for isolating magnetically labelled particles from a non-magnetic medium comprising a body portion (1) having a magnetising portion (3) for providing a magnetic field and a surface by means of which the body portion may stand on a supporting surface; and a sample vessel retaining portion (4) for retaining at least one sample vessel (5), wherein, the magnetising portion (3) is configured to conform at least approximately to at least a substantial portion of the longitudinal profile of at least one sample vessel (5); the sample vessel retaining portion (4) is configured to retain at least one sample vessel (5) such that at least a portion of the contents of the sample vessel (5) is visible to a user; and the sample vessel retaining portion (4) is configured to be mountable on the magnetising portion so that in use, the at least one sample vessel is subject to the magnetic field of the magnetising portion (3). The disclosure further relates to a kit of parts and a method for isolating magnetically labelled particles from a non-magnetic medium using the magnetic separation device.
摘要翻译： 本公开涉及一种用于从非磁性介质中分离磁性标记的颗粒的磁分离装置，其包括具有用于提供磁场的磁化部分（3）的主体部分（1）和主体部分可以支撑的表面 在支撑面上 以及用于保持至少一个样品容器（5）的样品容器保持部分（4），其中，所述磁化部分（3）构造成使至少大致至少大致至少一部分至少一个样品的纵向轮廓 船只（5）; 样品容器保持部分（4）构造成保持至少一个样品容器（5），使得样品容器（5）的内容物的至少一部分对使用者是可见的; 并且样品容器保持部（4）被构造成可安装在磁化部分上，使得在使用中，至少一个样品容器受到磁化部分（3）的磁场的影响。 本发明还涉及使用磁选机从非磁性介质中分离磁性标记的颗粒的一组零件和方法。
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公开(公告)号：US5856463A
公开(公告)日：1999-01-05
申请号：US715568
申请日：1996-09-18
IPC分类号： C12N15/09 , A61K31/7105 , A61K38/00 , A61K48/00 , A61P9/10 , A61P37/06 , C12N5/10 , C12N9/00 , C12N9/12 , C12N15/113 , C07H21/04 , C12Q1/68
CPC分类号： C12N15/1137 , C12N9/1205 , C12Y207/01037 , A61K38/00 , C12N2310/121 , C12N2310/122 , C12N2310/321
摘要： Disclosed is a purified full-length cDNA molecule encoding putative serine kinase enzyme (PSKH-1), and the expression of the cDNA in a recombinant host cell to produce substantially purified PSKH-1, per se. Inactivation of PSKH-1 pre-MRNA or PSKH-1 mRNA halts DNA synthesis and cell division. Also disclosed are ribozymes capable of cleaving PSKH-1 pre-mRNA or mRNA and thus deactivating PSKH-1 translation. Ribozymes of the hammerhead and hairpin motifs, and various compositions containing same, are also disclosed. The ribozymes compositions are used in the treatment of mammalian patients suffering from diseases or medical conditions characterized by abnormal cell proliferation or growth such as cancer and various non-malignant diseases or medical conditions such as autoimmune diseases, allograft rejection and atherosclerosis.
摘要翻译： 公开了一种编码推定的丝氨酸激酶（PSKH-1）的纯化全长cDNA分子，以及cDNA在重组宿主细胞中的表达，以产生基本上纯化的PSKH-1本身。 PSKH-1前MRNA或PSKH-1 mRNA的失活停止DNA合成和细胞分裂。 还公开了能够切割PSKH-1前mRNA或mRNA并因此使PSKH-1翻译失活的核酶。 还公开了锤头和发夹基序的核酶和含有它们的各种组合物。 核酶组合物用于治疗患有以异常细胞增殖或生长为特征的疾病或医学病症的哺乳动物患者，例如癌症和各种非恶性疾病或医学病症如自身免疫疾病，同种异体移植排斥和动脉粥样硬化。
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