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公开(公告)号：US07655763B2
公开(公告)日：2010-02-02
申请号：US11777525
申请日：2007-07-13
申请人： Geertruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
发明人： Geertruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/622
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle or bone, or disorders of insulin metabolism.
摘要翻译： 本公开提供针对生长和分化因子-8（GDF-8），特别是人抗体和抗体片段的新型抗体，包括在体外和/或体内抑制GDF-8活性的抗体片段。 本公开还提供了用于诊断，预防或治疗肌肉或骨骼退行性疾病或胰岛素代谢紊乱的方法。
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公开(公告)号：US08420082B2
公开(公告)日：2013-04-16
申请号：US12632383
申请日：2009-12-07
申请人： Geertruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
发明人： Geertruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00 , C07K16/18 , C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/622
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle or bone, or disorders of insulin metabolism.
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公开(公告)号：US20110243953A1
公开(公告)日：2011-10-06
申请号：US12632383
申请日：2009-12-07
申请人： Geertruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
发明人： Geertruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
IPC分类号： A61K39/395 , C07K16/22 , C07H21/04 , A61P21/00 , A61P19/08 , A61P11/00 , A61P3/10 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/02 , A61P3/04 , A61P3/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/622
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle or bone, or disorders of insulin metabolism.
摘要翻译： 本公开提供针对生长和分化因子-8（GDF-8），特别是人抗体和抗体片段的新型抗体，包括在体外和/或体内抑制GDF-8活性的抗体片段。 本公开还提供了用于诊断，预防或治疗肌肉或骨骼退行性疾病或胰岛素代谢紊乱的方法。
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公开(公告)号：US07261893B2
公开(公告)日：2007-08-28
申请号：US10688925
申请日：2003-10-21
申请人： Geertruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
发明人： Geertruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
IPC分类号： A61K39/395 , C12P21/08
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/622
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle or bone, or disorders of insulin metabolism.
摘要翻译： 本公开提供针对生长和分化因子-8（GDF-8），特别是人抗体和抗体片段的新型抗体，包括在体外和/或体内抑制GDF-8活性的抗体片段。 本公开还提供了用于诊断，预防或治疗肌肉或骨骼退行性疾病或胰岛素代谢紊乱的方法。
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公开(公告)号：US20130287762A1
公开(公告)日：2013-10-31
申请号：US13691395
申请日：2012-11-30
申请人： Geetruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove , Anne Field , Caroline Russell , Viia Valge-Archer
发明人： Geetruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove , Anne Field , Caroline Russell , Viia Valge-Archer
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/622
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle or bone, or disorders of insulin metabolism.
摘要翻译： 本公开提供针对生长和分化因子-8（GDF-8），特别是人抗体和抗体片段的新型抗体，包括在体外和/或体内抑制GDF-8活性的抗体片段。 本公开还提供了用于诊断，预防或治疗肌肉或骨骼退行性疾病或胰岛素代谢紊乱的方法。
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公开(公告)号：US20080044410A1
公开(公告)日：2008-02-21
申请号：US11777525
申请日：2007-07-13
申请人： Geertruida Veldman , Monique Davies , Kening Song , Neil Wolfman , Kristie Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
发明人： Geertruida Veldman , Monique Davies , Kening Song , Neil Wolfman , Kristie Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
IPC分类号： A61K39/395 , A61P19/00 , A61P19/08 , A61P21/00 , C07H21/02 , C07H21/04 , C07K16/22 , C07K16/44 , C12N15/85 , C12N5/10
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/622
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle or bone, or disorders of insulin metabolism.
摘要翻译： 本公开提供针对生长和分化因子-8（GDF-8），特别是人抗体和抗体片段的新型抗体，包括在体外和/或体内抑制GDF-8活性的抗体片段。 本公开还提供了用于诊断，预防或治疗肌肉或骨骼退行性疾病或胰岛素代谢紊乱的方法。
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公开(公告)号：US08182817B2
公开(公告)日：2012-05-22
申请号：US12696434
申请日：2010-01-29
申请人： Davinder S. Gill , Jing Li , Geertruida M. Veldman , Lynette A. Fouser , Viia Valge-Archer , David C. Lowe , Caroline S. Russell , Suzanne E. Cohen , Albert G. Thom , Ralph R. Minter
发明人： Davinder S. Gill , Jing Li , Geertruida M. Veldman , Lynette A. Fouser , Viia Valge-Archer , David C. Lowe , Caroline S. Russell , Suzanne E. Cohen , Albert G. Thom , Ralph R. Minter
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22 activity, thereby modulating immune responses in general, and those mediated by IL-22 in particular. The disclosed compositions and methods may be used for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, septic shock, infectious disorders, transplant rejection, cancer, and other immune system disorders.
摘要翻译： 本申请提供特异性结合人白细胞介素-22（IL-22）的人抗体及其抗原结合片段。 抗体可以作为IL-22活性的拮抗剂，从而调节一般的免疫应答，特别是由IL-22介导的那些。 所公开的组合物和方法可用于例如诊断，治疗或预防炎性疾病，自身免疫性疾病，过敏，败血性休克，感染性疾病，移植排斥，癌症和其他免疫系统疾病。
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公开(公告)号：US07901684B2
公开(公告)日：2011-03-08
申请号：US11708061
申请日：2007-02-20
申请人： Davinder S. Gill , Jing Li , Geertruida M. Veldman , Lynette A. Fouser , Viia Valge-Archer , David C. Lowe , Caroline S. Russell , Suzanne E. Cohen , Albert G. Thom , Ralph R. Minter
发明人： Davinder S. Gill , Jing Li , Geertruida M. Veldman , Lynette A. Fouser , Viia Valge-Archer , David C. Lowe , Caroline S. Russell , Suzanne E. Cohen , Albert G. Thom , Ralph R. Minter
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22 activity, thereby modulating immune responses in general, and those mediated by IL-22 in particular. The disclosed compositions and methods may be used for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, septic shock, infectious disorders, transplant rejection, cancer, and other immune system disorders.
摘要翻译： 本申请提供特异性结合人白细胞介素-22（IL-22）的人抗体及其抗原结合片段。 抗体可以作为IL-22活性的拮抗剂，从而调节一般的免疫应答，特别是由IL-22介导的那些。 所公开的组合物和方法可用于例如诊断，治疗或预防炎性疾病，自身免疫性疾病，过敏，败血性休克，感染性疾病，移植排斥，癌症和其他免疫系统疾病。
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公开(公告)号：US20100184960A1
公开(公告)日：2010-07-22
申请号：US12696434
申请日：2010-01-29
申请人： Davinder S. Gill , Jing Li , Geertruida M. Veldman , Lynette A. Fouser , Viia Valge-Archer , David C. Lowe , Caroline S. Russell , Suzanne E. Cohen , Albert G. Thom , Ralph R. Minter
发明人： Davinder S. Gill , Jing Li , Geertruida M. Veldman , Lynette A. Fouser , Viia Valge-Archer , David C. Lowe , Caroline S. Russell , Suzanne E. Cohen , Albert G. Thom , Ralph R. Minter
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22 activity, thereby modulating immune responses in general, and those mediated by IL-22 in particular. The disclosed compositions and methods may be used for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, septic shock, infectious disorders, transplant rejection, cancer, and other immune system disorders.
摘要翻译： 本申请提供特异性结合人白细胞介素-22（IL-22）的人抗体及其抗原结合片段。 抗体可以作为IL-22活性的拮抗剂，从而调节一般的免疫应答，特别是由IL-22介导的那些。 所公开的组合物和方法可用于例如诊断，治疗或预防炎性疾病，自身免疫性疾病，过敏，败血性休克，感染性疾病，移植排斥，癌症和其他免疫系统疾病。
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公开(公告)号：US08470993B2
公开(公告)日：2013-06-25
申请号：US13477717
申请日：2012-05-22
申请人： Davinder S. Gill , Jing Li , Geertruida M. Veldman , Lynette A. Fouser , Viia Valge-Archer , David C. Lowe , Caroline S. Russell , Suzanne E. Cohen , Albert G. Thom , Ralph R. Minter
发明人： Davinder S. Gill , Jing Li , Geertruida M. Veldman , Lynette A. Fouser , Viia Valge-Archer , David C. Lowe , Caroline S. Russell , Suzanne E. Cohen , Albert G. Thom , Ralph R. Minter
CPC分类号： C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22 activity, thereby modulating immune responses in general, and those mediated by IL-22 in particular. The disclosed compositions and methods may be used for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, septic shock, infectious disorders, transplant rejection, cancer, and other immune system disorders.
摘要翻译： 本申请提供特异性结合人白细胞介素-22（IL-22）的人抗体及其抗原结合片段。 抗体可以作为IL-22活性的拮抗剂，从而调节一般的免疫应答，特别是由IL-22介导的那些。 所公开的组合物和方法可用于例如诊断，治疗或预防炎性疾病，自身免疫性疾病，过敏，败血性休克，感染性疾病，移植排斥，癌症和其他免疫系统疾病。
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