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公开(公告)号：US07655763B2
公开(公告)日：2010-02-02
申请号：US11777525
申请日：2007-07-13
申请人： Geertruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
发明人： Geertruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/622
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle or bone, or disorders of insulin metabolism.
摘要翻译： 本公开提供针对生长和分化因子-8（GDF-8），特别是人抗体和抗体片段的新型抗体，包括在体外和/或体内抑制GDF-8活性的抗体片段。 本公开还提供了用于诊断，预防或治疗肌肉或骨骼退行性疾病或胰岛素代谢紊乱的方法。
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公开(公告)号：US08420082B2
公开(公告)日：2013-04-16
申请号：US12632383
申请日：2009-12-07
申请人： Geertruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
发明人： Geertruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00 , C07K16/18 , C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/622
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle or bone, or disorders of insulin metabolism.
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公开(公告)号：US20110243953A1
公开(公告)日：2011-10-06
申请号：US12632383
申请日：2009-12-07
申请人： Geertruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
发明人： Geertruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
IPC分类号： A61K39/395 , C07K16/22 , C07H21/04 , A61P21/00 , A61P19/08 , A61P11/00 , A61P3/10 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/02 , A61P3/04 , A61P3/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/622
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle or bone, or disorders of insulin metabolism.
摘要翻译： 本公开提供针对生长和分化因子-8（GDF-8），特别是人抗体和抗体片段的新型抗体，包括在体外和/或体内抑制GDF-8活性的抗体片段。 本公开还提供了用于诊断，预防或治疗肌肉或骨骼退行性疾病或胰岛素代谢紊乱的方法。
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公开(公告)号：US07261893B2
公开(公告)日：2007-08-28
申请号：US10688925
申请日：2003-10-21
申请人： Geertruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
发明人： Geertruida M. Veldman , Monique V. Davies , Kening Song , Neil M. Wolfman , Kristie Grove Bridges , Anne Field , Caroline Russell , Viia Valge-Archer
IPC分类号： A61K39/395 , C12P21/08
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/622
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle or bone, or disorders of insulin metabolism.
摘要翻译： 本公开提供针对生长和分化因子-8（GDF-8），特别是人抗体和抗体片段的新型抗体，包括在体外和/或体内抑制GDF-8活性的抗体片段。 本公开还提供了用于诊断，预防或治疗肌肉或骨骼退行性疾病或胰岛素代谢紊乱的方法。
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5.发明授权Isolated nucleic acid molecule encoding an antibody that reduces GDF-8 activity 有权编码降低GDF-8活性的抗体的分离的核酸分子公开(公告)号：US08710202B2
公开(公告)日：2014-04-29
申请号：US13346042
申请日：2012-01-09
申请人： Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein , William J. Dunham
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： C07H21/04 , A61K39/395
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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公开(公告)号：US20120107928A1
公开(公告)日：2012-05-03
申请号：US13346042
申请日：2012-01-09
申请人： Jane Aghajanian , William J. Dunham , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
发明人： Jane Aghajanian , William J. Dunham , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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7.发明授权Method of increasing trabecular bone density in a patient in need thereof by an antibody against GDF-8 有权通过针对GDF-8的抗体在有需要的患者中增加小梁骨密度的方法公开(公告)号：US08092798B2
公开(公告)日：2012-01-10
申请号：US12785975
申请日：2010-05-24
申请人： Jane Aghajanian , William J. Dunham, legal representative , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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公开(公告)号：US20110020330A1
公开(公告)日：2011-01-27
申请号：US12785975
申请日：2010-05-24
申请人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein , William J. Dunham
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein , William J. Dunham
IPC分类号： A61K39/395 , C07H21/04 , A61P19/08 , C12N5/07
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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9.发明授权Methods of increasing muscle mass or muscle strength using antibody inhibitors of GDF-8 有权使用GDF-8的抗体抑制剂增加肌肉质量或肌肉力量的方法公开(公告)号：US07731961B1
公开(公告)日：2010-06-08
申请号：US11737419
申请日：2007-04-19
申请人： Jane Aghajanian , William J. Dunham, legal representative , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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10.发明授权Structure-based approach to design of inhibitors of protein-processivity factor interactions 有权基于结构的蛋白质 - 加速因子相互作用抑制剂设计方法公开(公告)号：US07388070B1
公开(公告)日：2008-06-17
申请号：US09959948
申请日：2000-05-12
申请人： Donald Coen , James Hogle , Carl Elkin , Harmon J. Zuccola , Kristie Grove Bridges , Scott Lokey
发明人： Donald Coen , James Hogle , Carl Elkin , Harmon J. Zuccola , Kristie Grove Bridges , Scott Lokey
IPC分类号： C07C237/24 , C07D237/24 , A61K31/16 , A61P31/00 , A61P35/00
CPC分类号： C07D233/64
摘要： A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor interface is given. Methods for the structure-based inhibition of processivity factor binding to protein are also given. One embodiment includes a class of peptidomimetics that mimic helical portions of proteins. In addition, methods of treatment of various diseases are given, using the inhibitors of the invention.
摘要翻译： 本文公开了基于结构的鉴定和选择结合蛋白质的过程因子抑制剂的方法。 给出了蛋白质/加工因子界面的表征。 还给出了基于结构的抑制结合蛋白质的过程性因子的方法。 一个实施方案包括模拟蛋白质的螺旋部分的一类肽模拟物。 此外，使用本发明的抑制剂给出各种疾病的治疗方法。
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