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    Dopaminergic neurons derived from corneal limbus, methods of isolation and uses thereof
    1.
    发明授权
    Dopaminergic neurons derived from corneal limbus, methods of isolation and uses thereof 失效
    衍生自角膜缘角质的多巴胺能神经元，分离方法及其应用

    公开(公告)号：US08187875B2

    公开(公告)日：2012-05-29

    申请号：US11502338

    申请日：2006-08-10

    申请人： Geeta Ravindran ,  Harinarayana Rao

    发明人： Geeta Ravindran ,  Harinarayana Rao

    IPC分类号： C12N5/071

    CPC分类号： C12N5/0607 ,  A61K35/30 ,  C12N5/0621 ,  C12N2500/25 ,  C12N2500/30 ,  C12N2500/62 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/235 ,  C12N2506/08 ,  C12N2533/32 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/90

    摘要： The present disclosure describes the generation of neural cells and neurons from mammalian pluripotent embryonic-like stem cells (ELSCs) isolated from corneal limbal tissue, a non-embryonic tissue. Specifically, the present disclosure describes the generation of neuroprogenitor cells and differentiated dopaminergic neurons from ELSCs. The disclosed methods demonstrate the potential of ELSCs as a therapeutic tool, and may provide new therapeutic alternatives for various diseases, conditions, and injuries. Neuroprogenitor cells generated from ELSCs isolated from corneo-limbal tissue were transplanted into a rat model of Parkinson's disease, and were able to alleviate motor abnormalities in the rats for at least six months.

    摘要翻译： 本公开描述从分离自角膜缘角膜缘组织（非胚胎组织）的哺乳动物多能胚胎样干细胞（ELSC）产生神经细胞和神经元。 具体地，本公开描述了来自ELSC的神经祖细胞和分化的多巴胺能神经元的产生。 所公开的方法证明了ELSC作为治疗工具的潜力，并且可以为各种疾病，病症和损伤提供新的治疗替代物。 将从角膜缘组织分离的ELSC产生的神经祖细胞移植到帕金森病的大鼠模型中，并能够减轻大鼠运动异常至少6个月。

    Dopaminergic neurons derived from corneal limbus, methods of isolation and uses thereof
    2.
    发明申请
    Dopaminergic neurons derived from corneal limbus, methods of isolation and uses thereof 失效
    衍生自角膜缘角质的多巴胺能神经元，分离方法及其应用

    公开(公告)号：US20070020247A1

    公开(公告)日：2007-01-25

    申请号：US11502338

    申请日：2006-08-10

    申请人： Geeta Ravindran ,  Harinarayana Rao

    发明人： Geeta Ravindran ,  Harinarayana Rao

    IPC分类号： A61K35/30 ,  C12N5/08

    CPC分类号： C12N5/0607 ,  A61K35/30 ,  C12N5/0621 ,  C12N2500/25 ,  C12N2500/30 ,  C12N2500/62 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/235 ,  C12N2506/08 ,  C12N2533/32 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/90

    摘要： The present disclosure describes the generation of neural cells and neurons from mammalian pluripotent embryonic-like stem cells (ELSCs) isolated from corneal limbal tissue, a non-embryonic tissue. Specifically, the present disclosure describes the generation of neuroprogenitor cells and differentiated dopaminergic neurons from ELSCs. The disclosed methods demonstrate the potential of ELSCs as a therapeutic tool, and may provide new therapeutic alternatives for various diseases, conditions, and injuries. Neuroprogenitor cells generated from ELSCs isolated from corneo-limbal tissue were transplanted into a rat model of Parkinson's disease, and were able to alleviate motor abnormalities in the rats for at least six months.

    摘要翻译： 本公开描述从分离自角膜缘角膜缘组织（非胚胎组织）的哺乳动物多能胚胎样干细胞（ELSC）产生神经细胞和神经元。 具体地，本公开描述了来自ELSC的神经祖细胞和分化的多巴胺能神经元的产生。 所公开的方法证明了ELSC作为治疗工具的潜力，并且可以为各种疾病，病症和损伤提供新的治疗替代物。 将从角膜缘组织分离的ELSC产生的神经祖细胞移植到帕金森病的大鼠模型中，并能够减轻大鼠运动异常至少6个月。