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1.发明授权Agent and compositions comprising the same for inhibiting lipases and phospholipases in body fluids, cells and tissues 失效包含其用于抑制体液，细胞和组织中的脂肪酶和磷脂酶的药剂和组合物公开(公告)号：US07368529B2
公开(公告)日：2008-05-06
申请号：US11093637
申请日：2005-03-30
CPC分类号： C07K14/415 , A61K38/00 , C12N15/8247
摘要： The present invention deals with a protein and compositions comprising the same for inhibition of lipases and phospholipases in the body fluids, cells, and tissues for the prevention and treatment of metabolic syndrome, cardiovascular disorders, and inflammatory diseases. The protein is either isolated from plant species or synthesized or produced by recombinant DNA technology.
摘要翻译： 本发明涉及一种蛋白质和包含其的组合物，其用于抑制体液，细胞和组织中的脂肪酶和磷脂酶，用于预防和治疗代谢综合征，心血管疾病和炎性疾病。 蛋白质可以从植物物种中分离出来，也可以通过重组DNA技术合成或产生。
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2.发明授权Dopaminergic neurons derived from corneal limbus, methods of isolation and uses thereof 失效衍生自角膜缘角质的多巴胺能神经元，分离方法及其应用公开(公告)号：US08187875B2
公开(公告)日：2012-05-29
申请号：US11502338
申请日：2006-08-10
申请人： Geeta Ravindran , Harinarayana Rao
发明人： Geeta Ravindran , Harinarayana Rao
IPC分类号： C12N5/071
CPC分类号： C12N5/0607 , A61K35/30 , C12N5/0621 , C12N2500/25 , C12N2500/30 , C12N2500/62 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/235 , C12N2506/08 , C12N2533/32 , C12N2533/52 , C12N2533/54 , C12N2533/90
摘要： The present disclosure describes the generation of neural cells and neurons from mammalian pluripotent embryonic-like stem cells (ELSCs) isolated from corneal limbal tissue, a non-embryonic tissue. Specifically, the present disclosure describes the generation of neuroprogenitor cells and differentiated dopaminergic neurons from ELSCs. The disclosed methods demonstrate the potential of ELSCs as a therapeutic tool, and may provide new therapeutic alternatives for various diseases, conditions, and injuries. Neuroprogenitor cells generated from ELSCs isolated from corneo-limbal tissue were transplanted into a rat model of Parkinson's disease, and were able to alleviate motor abnormalities in the rats for at least six months.
摘要翻译： 本公开描述从分离自角膜缘角膜缘组织（非胚胎组织）的哺乳动物多能胚胎样干细胞（ELSC）产生神经细胞和神经元。 具体地，本公开描述了来自ELSC的神经祖细胞和分化的多巴胺能神经元的产生。 所公开的方法证明了ELSC作为治疗工具的潜力，并且可以为各种疾病，病症和损伤提供新的治疗替代物。 将从角膜缘组织分离的ELSC产生的神经祖细胞移植到帕金森病的大鼠模型中，并能够减轻大鼠运动异常至少6个月。
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3.发明申请Dopaminergic neurons derived from corneal limbus, methods of isolation and uses thereof 失效衍生自角膜缘角质的多巴胺能神经元，分离方法及其应用公开(公告)号：US20070020247A1
公开(公告)日：2007-01-25
申请号：US11502338
申请日：2006-08-10
申请人： Geeta Ravindran , Harinarayana Rao
发明人： Geeta Ravindran , Harinarayana Rao
CPC分类号： C12N5/0607 , A61K35/30 , C12N5/0621 , C12N2500/25 , C12N2500/30 , C12N2500/62 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/235 , C12N2506/08 , C12N2533/32 , C12N2533/52 , C12N2533/54 , C12N2533/90
摘要： The present disclosure describes the generation of neural cells and neurons from mammalian pluripotent embryonic-like stem cells (ELSCs) isolated from corneal limbal tissue, a non-embryonic tissue. Specifically, the present disclosure describes the generation of neuroprogenitor cells and differentiated dopaminergic neurons from ELSCs. The disclosed methods demonstrate the potential of ELSCs as a therapeutic tool, and may provide new therapeutic alternatives for various diseases, conditions, and injuries. Neuroprogenitor cells generated from ELSCs isolated from corneo-limbal tissue were transplanted into a rat model of Parkinson's disease, and were able to alleviate motor abnormalities in the rats for at least six months.
摘要翻译： 本公开描述从分离自角膜缘角膜缘组织（非胚胎组织）的哺乳动物多能胚胎样干细胞（ELSC）产生神经细胞和神经元。 具体地，本公开描述了来自ELSC的神经祖细胞和分化的多巴胺能神经元的产生。 所公开的方法证明了ELSC作为治疗工具的潜力，并且可以为各种疾病，病症和损伤提供新的治疗替代物。 将从角膜缘组织分离的ELSC产生的神经祖细胞移植到帕金森病的大鼠模型中，并能够减轻大鼠运动异常至少6个月。
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