公开(公告)号：US07939116B2

公开(公告)日：2011-05-10

申请号：US12898926

申请日：2010-10-06

申请人： Gen-ichiro Nonaka ,  Buxiang Sun ,  Lan Yuan ,  Takashi Nakagawa ,  Hajime Fujii ,  Young-Joon Surh

发明人： Gen-ichiro Nonaka ,  Buxiang Sun ,  Lan Yuan ,  Takashi Nakagawa ,  Hajime Fujii ,  Young-Joon Surh

IPC分类号： A61K36/87

CPC分类号： C07D311/62 ,  A23L33/105

摘要： Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.

摘要翻译： 提供：通过降低植物中原花色素的分子量来生产含硫原花色素寡聚物的方法，使得它们可以容易地通过生物体的肠被吸收; 以及含有所得含硫原花青素低聚物作为活性成分的保健食品组合物和药物组合物，其可用于治疗和预防由生成活性氧物质引起的各种与生活方式有关的疾病和脑疾病以及用于预防 老化。

公开(公告)号：US08088419B2

公开(公告)日：2012-01-03

申请号：US12898946

申请日：2010-10-06

申请人： Gen-ichiro Nonaka ,  Buxiang Sun ,  Lan Yuan ,  Takashi Nakagawa ,  Hajime Fujii ,  Young-Joon Surh

发明人： Gen-ichiro Nonaka ,  Buxiang Sun ,  Lan Yuan ,  Takashi Nakagawa ,  Hajime Fujii ,  Young-Joon Surh

IPC分类号： A01N37/10 ,  A61K31/665 ,  A61K31/66

CPC分类号： C07D311/62 ,  A23L33/105

摘要： Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.

摘要翻译： 提供：通过降低植物中原花色素的分子量来生产含硫原花色素寡聚物的方法，使得它们可以容易地通过生物体的肠被吸收; 以及含有所得含硫原花青素低聚物作为活性成分的保健食品组合物和药物组合物，其可用于治疗和预防由生成活性氧物质引起的各种与生活方式有关的疾病和脑疾病以及用于预防 老化。

公开(公告)号：US07833553B2

公开(公告)日：2010-11-16

申请号：US10513950

申请日：2004-05-25

申请人： Gen-ichiro Nonaka ,  Buxiang Sun ,  Lan Yuan ,  Takashi Nakagawa ,  Hajime Fujii ,  Young-Joon Surh

发明人： Gen-ichiro Nonaka ,  Buxiang Sun ,  Lan Yuan ,  Takashi Nakagawa ,  Hajime Fujii ,  Young-Joon Surh

IPC分类号： A61K36/87

CPC分类号： C07D311/62 ,  A23L33/105

摘要： Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.

摘要翻译： 提供：通过降低植物中原花色素的分子量来生产含硫原花色素寡聚物的方法，使得它们可以容易地通过生物体的肠被吸收; 以及含有所得含硫原花青素低聚物作为活性成分的保健食品组合物和药物组合物，其可用于治疗和预防由生成活性氧物质引起的各种与生活方式有关的疾病和脑疾病以及用于预防 老化。

公开(公告)号：US20050261198A1

公开(公告)日：2005-11-24

申请号：US10513950

申请日：2004-05-25

申请人： Gen-ichiro Nonaka ,  Buxiang Sun ,  Lan Yuan ,  Takashi Nakagawa ,  Hajime Fujii ,  Young-Joon Surh

发明人： Gen-ichiro Nonaka ,  Buxiang Sun ,  Lan Yuan ,  Takashi Nakagawa ,  Hajime Fujii ,  Young-Joon Surh

IPC分类号： A23L1/30 ,  A61P3/10 ,  A61P3/12 ,  A61P25/28 ,  A61P39/06 ,  C07D311/62 ,  A61K38/05 ,  A61K31/353

CPC分类号： C07D311/62 ,  A23L33/105

摘要： Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.

摘要翻译： 提供：通过降低植物中原花色素的分子量来生产含硫原花色素寡聚物的方法，使得它们可以容易地通过生物体的肠被吸收; 以及含有所得含硫原花青素低聚物作为活性成分的保健食品组合物和药物组合物，其可用于治疗和预防由生成活性氧物质引起的各种与生活方式有关的疾病和脑疾病以及用于预防 老化。

公开(公告)号：US20090047305A1

公开(公告)日：2009-02-19

申请号：US11814922

申请日：2006-02-24

申请人： Takashi Tanaka ,  Gen-ichiro Nonaka ,  Isao Kohno ,  Hajime Fujii ,  Takashi Nakagawa ,  Hiroshi Nishioka

发明人： Takashi Tanaka ,  Gen-ichiro Nonaka ,  Isao Kohno ,  Hajime Fujii ,  Takashi Nakagawa ,  Hiroshi Nishioka

IPC分类号： A61K31/352 ,  A61K36/00 ,  A61K36/87 ,  A61K36/15 ,  A61K36/736 ,  A61K36/732 ,  A61K36/82 ,  A61K36/04 ,  C07D311/04 ,  A61P25/28

CPC分类号： A61K31/353 ,  A61K8/498 ,  A61K36/04 ,  A61K36/14 ,  A61K36/15 ,  A61K36/185 ,  A61K36/45 ,  A61K36/485 ,  A61K36/54 ,  A61K36/61 ,  A61K36/73 ,  A61K36/734 ,  A61K36/74 ,  A61K36/77 ,  A61K36/82 ,  A61K36/87 ,  A61K36/88 ,  A61K36/889 ,  A61K2800/522 ,  A61Q19/08 ,  C07D311/62 ,  A61K2300/00

摘要： The present invention relates to a composition containing as its main component proanthocyanidin oligomer to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded, and reduced in the molecular weight, which is obtained by heating plant materials containing proanthocyanidin polymer or extract thereof with a substance having a phloroglucinol ring structure or resorcinol ring structure in an acidic aqueous solution, production method thereof, and uses of the composition in health products and pharmaceutical products. According to the invention, proanthocyanidin oligomer having physiological activity, to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight to such a level that the oligomer can be absorbed into living body, which has been conventionally difficult to obtain at high yield from plant raw materials, can be produced efficiently and easily.

摘要翻译： 本发明涉及一种含有原花青素低聚物的组合物，其中具有间苯三酚环结构或间苯二酚环结构的物质已经结合，并且通过加热含有原花色素聚合物或提取物的植物材料而得到的分子量降低 其在酸性水溶液中具有间苯三酚环结构或间苯二酚环结构的物质，其制备方法以及保健品和药品中的组合物的用途。 根据本发明，具有生理活性的具有间苯三酚环结构或间苯二酚环结构的物质的原花青素低聚物已经被结合并且分子量降低至低聚物可以吸收到生物体中的水平 通常难以从植物原料获得高产率，可以有效且容易地生产。