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    Method and composition for targeting an adenoviral vector
    2.
    发明申请
    Method and composition for targeting an adenoviral vector 审中-公开
    用于靶向腺病毒载体的方法和组合物

    公开(公告)号：US20030099619A1

    公开(公告)日：2003-05-29

    申请号：US10304160

    申请日：2002-11-25

    Applicant: GenVec, Inc.

    Inventor： Thomas J. Wickham ,  Imre Kovesdi ,  Petrus W. Roelvink ,  David Einfeld ,  Douglas E. Brough ,  Alena Lizonova

    IPC: A61K048/00 ,  C12Q001/70 ,  C12N015/861 ,  C07K014/705 ,  C07K014/075

    CPC classification number: C12N15/86 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2810/40 ,  C12N2810/405 ,  C12N2810/60 ,  C12N2810/80 ,  C12N2830/008

    Abstract: The invention provides adenoviral coat proteins comprising various non-native ligands. Further, the present invention provides an adenoviral vector that elicits less reticulo-endothelial system (RES) clearance in a host animal than a corresponding wild-type adenovirus. Also provided by the invention is a system comprising a cell having a non-native cell-surface receptor and a virus having a non-native ligand, wherein the non-native ligand of the virus binds the non-native cell-surface receptor of the cell. Using this system, a virus can be propagated. Further provided by the invention is a method of controlled gene expression utilizing selectively replication competence, a method of assaying for gene function, a method of isolating a nucleic acid, and a method of identifying functionally related coding sequences. Additionally, the invention provides a cell-surface receptor, which facilitates internalization.

    Abstract translation: 本发明提供了包含各种非天然配体的腺病毒外壳蛋白。 此外，本发明提供了一种腺病毒载体，其在宿主动物中比相应的野生型腺病毒引起较少的网状内皮系统（RES）清除。 本发明还提供了一种包含具有非天然细胞表面受体的细胞和具有非天然配体的病毒的系统的系统，其中所述病毒的非天然配体结合所述非天然细胞表面受体的非天然细胞表面受体 细胞。 使用该系统可以传播病毒。 本发明进一步提供了利用选择性复制能力的受控基因表达的方法，基因功能测定方法，分离核酸的方法和识别功能相关编码序列的方法。 另外，本发明提供了促进内化的细胞表面受体。

    Targeting adenovirus with use of constrained peptide motifs
    3.
    发明申请
    Targeting adenovirus with use of constrained peptide motifs 有权
    使用受限肽基序靶向腺病毒

    公开(公告)号：US20020151027A1

    公开(公告)日：2002-10-17

    申请号：US09969192

    申请日：2001-10-01

    Applicant: GenVec, Inc.

    Inventor： Thomas J. Wickham ,  Petrus W. Roelvink ,  Imre Kovesdi

    IPC: C12N015/861 ,  C12N009/50 ,  C12N007/01

    CPC classification number: C12N7/00 ,  A61K38/00 ,  A61K48/00 ,  C07K14/005 ,  C07K2319/00 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2810/40 ,  C12N2810/405 ,  C12N2810/60

    Abstract: The present invention provides a chimeric adenovirus fiber protein, which differs from the wild-type coat protein by the introduction of a nonnative amino acid sequence in a conformationally-restrained manner. Such a chimeric adenovirus fiber protein according to the invention is able to direct entry into cells of a vector comprising the chimeric fiber protein that is more efficient than entry into cells of a vector that is identical except for comprising a wild-type adenovirus fiber protein rather than the chimeric adenovirus fiber protein. The nonnative amino acid sequences encodes a peptide motif that comprises an epitope for an antibody, or a ligand for a cell surface receptor, that can be employed in cell targeting. The present invention also pertains to vectors comprising such a chimeric adenovirus fiber protein, and to methods of using such vectors.

    Abstract translation: 本发明提供了一种嵌合腺病毒纤维蛋白，其通过以构象约束的方式引入非氨基酸序列而与野生型外壳蛋白不同。 根据本发明的这种嵌合腺病毒纤维蛋白能够直接进入包含嵌合纤维蛋白质的载体的细胞，该载体比除了包含野生型腺病毒纤维蛋白的载体的细胞进入更有效，而不是包含野生型腺病毒纤维蛋白 比嵌合腺病毒纤维蛋白。 非氨基酸序列编码包含可用于细胞靶向的抗体表位或细胞表面受体配体的肽基序。 本发明还涉及包含这种嵌合腺病毒纤维蛋白的载体，以及使用这些载体的方法。

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