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    Implantable cardiac stimulation device providing reduced defibrillation thresholds and method
    1.
    发明授权
    Implantable cardiac stimulation device providing reduced defibrillation thresholds and method 有权
    植入式心脏刺激装置提供降低的除颤阈值和方法

    公开(公告)号：US07856266B1

    公开(公告)日：2010-12-21

    申请号：US11756283

    申请日：2007-05-31

    申请人： Gene A. Bornzin ,  Michael E. Benser ,  Euljoon Park ,  Taraneh Ghaffari Farazi

    发明人： Gene A. Bornzin ,  Michael E. Benser ,  Euljoon Park ,  Taraneh Ghaffari Farazi

    IPC分类号： A61N1/39

    CPC分类号： A61N1/3962 ,  A61N1/3622 ,  A61N1/36521 ,  A61N1/3943

    摘要： An implantable cardiac defibrillation device provides pre-shock stimuli to reduce the defibrillation threshold (DFT). The device includes an arrhythmia detector that detects fibrillation of a fibrillating chamber of a heart and a pulse generator that provides a fibrillation therapy output responsive to the arrhythmia detector detecting fibrillation of the fibrillating chamber of the heart. The therapy output includes a defibrillating shock having an output magnitude exceeding a temporary defibrillation threshold of the fibrillating chamber and at least one pre-defibrillating shock output pulse that reduces an initial defibrillation threshold of the fibrillating chamber to the temporary defibrillation threshold. An electrode system having at least two defibrillation electrodes delivers both the at least one pre-defibrillating shock output pulse to the heart and the defibrillating shock to the fibrillating chamber of the heart.

    摘要翻译： 植入式心脏除颤装置提供预冲击刺激以减少除颤阈值（DFT）。 该装置包括心律失常检测器，其检测心脏的原纤化室的原纤维和脉冲发生器，其提供响应于心律失常检测器检测心脏原纤化室的纤颤的原纤维化治疗输出。 治疗输出包括具有超过原纤化室的暂时除颤阈值的输出量值的至少一个除纤颤前冲击输出脉冲，其将原纤化室的初始除颤阈值降低到临时除颤阈值。 具有至少两个除颤电极的电极系统将至少一个除颤前的冲击输出脉冲和心脏的去纤维化颤动传递给心脏的原纤维室。

    SYSTEMS AND METHODS FOR USE BY IMPLANTABLE MEDICAL DEVICES FOR DETECTING AND DISCRIMINATING STROKE AND CARDIAC ISCHEMIA USING ELECTROCARDIAC SIGNALS
    3.
    发明申请
    SYSTEMS AND METHODS FOR USE BY IMPLANTABLE MEDICAL DEVICES FOR DETECTING AND DISCRIMINATING STROKE AND CARDIAC ISCHEMIA USING ELECTROCARDIAC SIGNALS 有权
    用于通过电刺激信号检测和鉴别卒中和心脏病的植入式医疗设备使用的系统和方法

    公开(公告)号：US20130041274A1

    公开(公告)日：2013-02-14

    申请号：US13207307

    申请日：2011-08-10

    申请人： Jong Gill ,  Rupinder Bharmi ,  Edward Karst ,  Ryan Rooke ,  Riddhi Shah ,  Fujian Qu ,  Gene A. Bornzin ,  Taraneh Ghaffari Farazi ,  Euljoon Park

    发明人： Jong Gill ,  Rupinder Bharmi ,  Edward Karst ,  Ryan Rooke ,  Riddhi Shah ,  Fujian Qu ,  Gene A. Bornzin ,  Taraneh Ghaffari Farazi ,  Euljoon Park

    IPC分类号： A61B5/0468

    CPC分类号： A61B5/0468 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/02158 ,  A61B5/02405 ,  A61B5/0295 ,  A61B5/0422 ,  A61B5/4839 ,  A61N1/3702

    摘要： Techniques are provided for detecting and distinguishing stroke and cardiac ischemia based on electrocardiac signals. In one example, the device senses atrial and ventricular signals within the patient along a set of unipolar sensing vectors and identifies certain morphological features within the signals such as PR intervals, ST intervals, QT intervals, T-waves, etc. The device detects changes, if any, within the morphological features such as significant shifts in ST interval elevation or an inversion in T-wave shape, which are indicative of stroke or cardiac ischemia. By selectively comparing changes detected along different unipolar sensing vectors, the device distinguishes or discriminates stroke from cardiac ischemia within the patient. The discrimination may be corroborated using various physiological and hemodynamic parameters. In some examples, the device further identifies the location of the ischemia within the heart. In still other examples, the device detects cardiac ischemia occurring during stroke.

    摘要翻译： 提供了用于基于心电信号检测和区分中风和心脏缺血的技术。 在一个示例中，该装置沿着一组单极感测向量感测患者内的心房和心室信号，并且识别信号内的某些形态特征，例如PR间隔，ST间隔，QT间隔，T波等。该装置检测变化 （如果有的话）在形态学特征之中，例如ST间期升高的显着变化或T波形的反转，其指示中风或心脏缺血。 通过选择性地比较沿着不同的单极性感测向量检测的变化，该装置区分或区分患者体内的心脏缺血的中风。 可以使用各种生理和血液动力学参数来确认辨别。 在一些实例中，该装置还识别心脏内局部缺血的位置。 在另外的例子中，该装置检测在中风期间发生的心脏缺血。

    CARDIAC ANALYSIS SYSTEM FOR COMPARING CLINICAL AND INDUCED VENTRICULAR TACHYCARDIA EVENTS
    4.
    发明申请
    CARDIAC ANALYSIS SYSTEM FOR COMPARING CLINICAL AND INDUCED VENTRICULAR TACHYCARDIA EVENTS 有权
    用于比较临床和诱发的心室TACHYCARDIA事件的心脏分析系统

    公开(公告)号：US20110282226A1

    公开(公告)日：2011-11-17

    申请号：US12820879

    申请日：2010-06-22

    申请人： Michael E. Benser ,  Gene A. Bornzin ,  Euljoon Park ,  Kyungmoo Ryu ,  Michael Hardage

    发明人： Michael E. Benser ,  Gene A. Bornzin ,  Euljoon Park ,  Kyungmoo Ryu ,  Michael Hardage

    IPC分类号： A61B5/04

    CPC分类号： A61B5/0422 ,  A61B5/0031 ,  A61B5/0464 ,  A61B18/1492 ,  A61N1/3621

    摘要： A cardiac analysis system is provided that includes an implantable medical device (IMD), at least one sensor, and an external device. The IMD has electrodes positioned proximate to a heart that sense first cardiac signals of the heart and associated with a clinical ventricular tachycardia (VT) event and second cardiac signals associated with an induced VT event. The sensor measures first and second cardiac parameters of the heart associated with the clinical and induced VT events, respectively. The external device is configured to receive the first and second cardiac signals associated with the clinical and the induced VT events and the first and second cardiac parameters associated with the clinical and the induced VT events. The external device compares the first and second cardiac signals and compares the first and second cardiac parameters to determine if the clinical and induced VT events are a common type of VT event.

    摘要翻译： 提供了包括可植入医疗装置（IMD），至少一个传感器和外部装置的心脏分析系统。 IMD具有位于心脏附近的电极，其感测心脏的第一心脏信号并与临床心室性心动过速（VT）事件和与诱导的VT事件相关联的第二心脏信号相关联。 该传感器分别测量与临床和诱导VT事件相关的心脏的第一和第二心脏参数。 外部设备被配置为接收与临床和诱导的VT事件相关联的第一和第二心脏信号以及与临床和诱导的VT事件相关联的第一和第二心脏参数。 外部设备比较第一和第二心脏信号，并比较第一和第二心脏参数以确定临床和诱导的VT事件是否是常见类型的VT事件。

    Cardiac analysis system for comparing clinical and induced ventricular tachycardia events
    5.
    发明授权
    Cardiac analysis system for comparing clinical and induced ventricular tachycardia events 有权
    用于比较临床和诱导性室性心动过速事件的心脏分析系统

    公开(公告)号：US08634902B2

    公开(公告)日：2014-01-21

    申请号：US12820879

    申请日：2010-06-22

    申请人： Michael E. Benser ,  Gene A. Bornzin ,  Euljoon Park ,  Kyungmoo Ryu ,  Michael Hardage

    发明人： Michael E. Benser ,  Gene A. Bornzin ,  Euljoon Park ,  Kyungmoo Ryu ,  Michael Hardage

    IPC分类号： A61B5/04

    CPC分类号： A61B5/0422 ,  A61B5/0031 ,  A61B5/0464 ,  A61B18/1492 ,  A61N1/3621

    摘要： A cardiac analysis system is provided that includes an implantable medical device (IMD), at least one sensor, and an external device. The IMD has electrodes positioned proximate to a heart that sense first cardiac signals of the heart and associated with a clinical ventricular tachycardia (VT) event and second cardiac signals associated with an induced VT event. The sensor measures first and second cardiac parameters of the heart associated with the clinical and induced VT events, respectively. The external device is configured to receive the first and second cardiac signals associated with the clinical and the induced VT events and the first and second cardiac parameters associated with the clinical and the induced VT events. The external device compares the first and second cardiac signals and compares the first and second cardiac parameters to determine if the clinical and induced VT events are a common type of VT event.

    摘要翻译： 提供了包括可植入医疗装置（IMD），至少一个传感器和外部装置的心脏分析系统。 IMD具有位于心脏附近的电极，其感测心脏的第一心脏信号并与临床心室性心动过速（VT）事件和与诱导的VT事件相关联的第二心脏信号相关联。 该传感器分别测量与临床和诱导VT事件相关的心脏的第一和第二心脏参数。 外部设备被配置为接收与临床和诱导的VT事件相关联的第一和第二心脏信号以及与临床和诱导的VT事件相关联的第一和第二心脏参数。 外部设备比较第一和第二心脏信号，并比较第一和第二心脏参数以确定临床和诱导的VT事件是否是常见类型的VT事件。

    Monitoring heart disease using implantable sensors and slopes determined therefrom
    7.
    发明授权
    Monitoring heart disease using implantable sensors and slopes determined therefrom 有权
    使用由其确定的可植入传感器和斜坡来监测心脏病

    公开(公告)号：US08170664B1

    公开(公告)日：2012-05-01

    申请号：US11931165

    申请日：2007-10-31

    申请人： Yelena Nabutovsky ,  Kyungmoo Ryu ,  Taraneh Ghaffari Farazi ,  Gene A. Bornzin

    发明人： Yelena Nabutovsky ,  Kyungmoo Ryu ,  Taraneh Ghaffari Farazi ,  Gene A. Bornzin

    IPC分类号： A61N1/37 ,  A61N1/08

    CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/3702

    摘要： Specific embodiments of the present invention use an implanted sensor, during a period of time, to measure a physiologic property when the patient's heart is not stressed, and when the patient's heart is stressed. A slope is determined, where the slope is indicative of a change in the physiologic property during the period of time. Heart disease is monitored based on a magnitude of the slope. In further embodiments of the present invention, a slope indicative of a change in a physiologic property during a period of time is determined, for each of a plurality of periods of time. Changes in the patient's heart disease are monitored based on changes in the slope.

    摘要翻译： 本发明的具体实施例在一段时间内使用植入式传感器来测量当患者的心脏没有受到压力时以及当患者的心脏被压力时的生理特性。 确定斜率，其中斜率表示在一段时间内生理特性的变化。 基于斜率的大小来监测心脏病。 在本发明的另外的实施例中，对于多个时间段中的每一个确定指示在一段时间内的生理特性变化的斜率。 根据斜率的变化监测患者心脏病变化。

    Painless ventricular rate control during supraventricular tachycardia
    8.
    发明授权
    Painless ventricular rate control during supraventricular tachycardia 有权
    室上性心动过速期间无痛心室率控制

    公开(公告)号：US08135464B1

    公开(公告)日：2012-03-13

    申请号：US11830499

    申请日：2007-07-30

    申请人： Taraneh Ghaffari Farazi ,  Gene A. Bornzin

    发明人： Taraneh Ghaffari Farazi ,  Gene A. Bornzin

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3624

    摘要： In various embodiments of the present invention, lower amplitude high frequency burst stimulation of cardiac fat pad(s) innervating the AV node and/or ventricle tissue performed in conjunction with ventricular pacing during refractory period is used to reduce the ventricular rate in order to terminate arrhythmias such as supraventricular tachycardia. In an embodiment of the present invention, one or more pace pulse delivered during a ventricular refractory period can be used to further extend the duration of the refractory period followed by a short burst of cardiac fat pad stimulation to temporarily slow AV conduction. In an embodiment of the present invention, this therapy slows the ventricular rate by altering conduction speed in both the AV node and the ventricles.

    摘要翻译： 在本发明的各种实施例中，使用在不稳定期间结合心室起搏执行支配AV结节和/或心室组织的心脏脂肪垫的较低振幅高频爆发刺激来降低心室率以终止 心律失常如室上性心动过速。 在本发明的一个实施方案中，可以使用在心室不应期期间递送的一个或多个步速脉冲来进一步延长不应期的持续时间，随后是心脏脂肪垫刺激的短暂爆发以暂时缓慢AV传导。 在本发明的一个实施方案中，该疗法通过改变AV节点和心室中的传导速度来减慢心室率。