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公开(公告)号:US20160199457A1
公开(公告)日:2016-07-14
申请号:US14644873
申请日:2015-03-11
申请人: GENENTECH, INC.
IPC分类号: A61K38/45
CPC分类号: A61K38/45 , A61K31/7088 , A61K31/7105 , A61K31/715 , A61K35/30 , A61K38/005 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/54 , C07K16/40 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C12N15/1137 , C12N15/115 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12Y207/11025 , A61K2300/00
摘要: The invention relates generally to treatment of neurological disorders and nervous system injuries. The invention specifically provides methods of using modulators of particular target proteins to modulate degeneration of neurons or portions thereof, such as axons.
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公开(公告)号:US20180325992A1
公开(公告)日:2018-11-15
申请号:US15908024
申请日:2018-02-28
申请人: Genentech, Inc.
发明人: Ryan J. WATTS , Mark CHEN , Joseph Wesley LEWCOCK , Christine POZNIAK , Arundhati SENGUPTA-GHOSH
IPC分类号: A61K38/12 , A61K31/711 , A61K31/7105 , C12N15/113 , A61K31/40 , A61K31/426 , A61K31/433 , A61K31/45 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/713 , C07K16/40 , A61K31/12 , A61K31/165 , A61K31/352 , A61K31/4184 , A61K31/277 , A61K31/35 , A61K31/4015 , A61K31/416 , A61K31/4439 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K33/14 , A61K38/05 , A61K38/18 , C07K16/22 , G01N33/50 , A61K31/7088
CPC分类号: A61K38/12 , A61K31/12 , A61K31/165 , A61K31/277 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4184 , A61K31/426 , A61K31/433 , A61K31/4439 , A61K31/45 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K33/14 , A61K38/05 , A61K38/185 , C07K16/22 , C07K16/40 , C07K2317/76 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2320/30 , G01N33/5058
摘要: The invention relates generally to treatment of neurological disorders and nervous system injuries. The invention specifically provides methods of using modulators of particular target proteins to modulate degeneration of neurons or portions thereof, such as axons.
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公开(公告)号:US20160161470A1
公开(公告)日:2016-06-09
申请号:US14822711
申请日:2015-08-10
申请人: GENENTECH, INC.
发明人: Ryan J. WATTS , Mark CHEN , Joseph Wesley LEWCOCK , Christine POZNIAK , Arundhati SENGUPTA-GHOSH
IPC分类号: G01N33/50 , C07K16/22 , A61K31/35 , A61K38/05 , A61K31/4015 , C12N15/113 , A61K31/52 , A61K31/277 , A61K33/14 , A61K31/4439 , A61K31/506 , A61K31/416 , A61K38/18 , A61K31/5377
CPC分类号: A61K38/12 , A61K31/12 , A61K31/165 , A61K31/277 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4184 , A61K31/426 , A61K31/433 , A61K31/4439 , A61K31/45 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K33/14 , A61K38/05 , A61K38/185 , C07K16/22 , C07K16/40 , C07K2317/76 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2320/30 , G01N33/5058
摘要: The invention relates generally to treatment of neurological disorders and nervous system injuries. The invention specifically provides methods of using modulators of particular target proteins to modulate degeneration of neurons or portions thereof, such as axons.
摘要翻译: 本发明一般涉及治疗神经系统疾病和神经系统损伤。 本发明具体提供了使用特定靶蛋白的调节剂调节神经元或其部分如轴突的变性的方法。
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公开(公告)号:US20160279190A1
公开(公告)日:2016-09-29
申请号:US14755809
申请日:2015-06-30
申请人: GENENTECH, INC.
发明人: Ryan J. WATTS , Mark CHEN , Joseph Wesley LEWCOCK , Christine POZNIAK , Arundhati SENGUPTA-GHOSH
IPC分类号: A61K38/12 , A61K31/4015 , A61K31/433 , A61K31/519 , A61K31/426 , A61K31/12 , A61K33/14 , A61K31/4439 , A61K31/506 , A61K31/277 , A61K31/517 , A61K31/165 , A61K31/5377 , A61K31/52 , A61K31/352 , A61K31/4184 , A61K31/496 , A61K31/505 , A61K31/40 , A61K31/45 , C12N15/113 , A61K31/713 , C07K16/40 , A61K38/05
CPC分类号: A61K38/12 , A61K31/12 , A61K31/165 , A61K31/277 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4184 , A61K31/426 , A61K31/433 , A61K31/4439 , A61K31/45 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K33/14 , A61K38/05 , A61K38/185 , C07K16/22 , C07K16/40 , C07K2317/76 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2320/30 , G01N33/5058
摘要: The invention relates generally to treatment of neurological disorders and nervous system injuries. The invention specifically provides methods of using modulators of particular target proteins to modulate degeneration of neurons or portions thereof, such as axons.
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