公开(公告)号：US20140213470A1

公开(公告)日：2014-07-31

申请号：US14086352

申请日：2013-11-21

Applicant: Genentech, Inc. ,  BIOGEN IDEC MA INC.

Inventor： Yen-Ming Hsu ,  Leonid Gorelik ,  Tatiana Novobrantseva ,  Joanne Quan ,  Flavius Martin ,  Susan L. Kalled

IPC: C12Q1/68 ,  G01N33/574 ,  G01N33/564 ,  G01N33/50 ,  G01N33/68

CPC classification number: C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/106 ,  G01N33/5041 ,  G01N33/564 ,  G01N33/57426 ,  G01N33/6872 ,  G01N2333/4706 ,  G01N2333/70539 ,  G01N2333/7056 ,  G01N2333/902 ,  G01N2800/52

Abstract: BAFF plays a central role in acquired immunity. The disclosure identifies BAFF responsive genes that are substantially upregulated by administration of BAFF and substantially downregulated by treatment with a BAFF antagonist. Specific genes are NF-κB2, CD23, H2-Mβ (the beta chain of H2-DM), Fig-1, and OBF-1. The disclosure provides methods and compositions for monitoring the activity of a BAFF antagonist in a mammal; monitoring BAFF activity in a mammal; identifying a mammal to be treated with a BAFF antagonist; and related uses. Such methods include detecting one or more molecules selected from the group consisting of Fig-1 molecule, OBF-1 molecule, and H2-Mβ molecule in a biological sample of the mammal, and optionally further detecting NF-κB2 molecule and/or CD23 molecule in the biological sample.

Abstract translation: BAFF在获得性免疫中起着核心作用。 本公开确定BAFF反应性基因，其通过施用BAFF基本上调，并且通过用BAFF拮抗剂治疗显着下调。 特定基因是NF-和Kgr; B2，CD23，H2-M＆bgr; （H2-DM的β链），图1和OBF-1。 本公开提供了用于监测哺乳动物中BAFF拮抗剂的活性的方法和组合物; 监测哺乳动物的BAFF活性; 鉴定要用BAFF拮抗剂治疗的哺乳动物; 和相关用途。 这样的方法包括检测选自图1分子，OBF-1分子和H 2 M＆amp; Bgr的一种或多种分子; 分子，并且任选地进一步检测生物样品中的NF-κB分子和/或CD23分子。

公开(公告)号：US09822400B2

公开(公告)日：2017-11-21

申请号：US14248135

申请日：2014-04-08

Applicant: Genentech, Inc.

Inventor： Glynn Dennis, Jr. ,  Flavius Martin ,  Michael J. Townsend

IPC: G01N33/53 ,  C12Q1/68 ,  A61K38/16 ,  G01N33/564 ,  C07K16/28

CPC classification number: C12Q1/6837 ,  A61K38/16 ,  C07K16/2887 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/564 ,  G01N2800/102 ,  G01N2800/52 ,  Y02A50/463

Abstract: Methods of identifying, diagnosing, and prognosing rheumatoid arthritis are provided, as well as methods of treating rheumatoid arthritis. Also provided are methods for identifying effective rheumatoid arthritis therapeutic agents and predicting responsiveness to rheumatoid arthritis therapeutic agents.