公开(公告)号：US09982302B2

公开(公告)日：2018-05-29

申请号：US15019615

申请日：2016-02-09

Applicant: Genentech, Inc.

Inventor： Timothy W. Behrens ,  Kasia Owczarczyk ,  Michael J. Townsend

IPC: C12Q1/68 ,  C07K14/705 ,  A61K38/00

CPC classification number: C12Q1/6883 ,  A61K38/00 ,  C07K14/70521 ,  C07K2319/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: Biological markers that predict patient responsiveness to B-cell antagonists are provided. Also provided are methods of using such biological markers. In addition, methods for identifying patients suffering from an autoimmune disease, e.g., rheumatoid arthritis, who are not likely to respond to B-cell antagonists are provided, as are methods of treating such patients. Methods for selecting therapeutic agents to treat such patients are also provided.

公开(公告)号：US20140154247A1

公开(公告)日：2014-06-05

申请号：US13974817

申请日：2013-08-23

Applicant: Genentech, Inc.

Inventor： Timothy W. Behrens ,  Kasia Owczarczyk ,  Michael J. Townsend

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  A61K38/00 ,  C07K14/70521 ,  C07K2319/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: Biological markers that predict patient responsiveness to B-cell antagonists are provided. Also provided are methods of using such biological markers. In addition, methods for identifying patients suffering from an autoimmune disease, e.g., rheumatoid arthritis, who are not likely to respond to B-cell antagonists are provided, as are methods of treating such patients. Methods for selecting therapeutic agents to treat such patients are also provided.

Abstract translation: 提供了预测患者对B细胞拮抗剂的反应性的生物标志物。 还提供了使用这种生物标记物的方法。 此外，提供了用于鉴定患有自身免疫性疾病例如类风湿性关节炎的患者的方法，所述患者不太可能对B细胞拮抗剂作出反应，以及治疗这些患者的方法。 还提供了用于选择治疗这些患者的治疗剂的方法。

公开(公告)号：US09822400B2

公开(公告)日：2017-11-21

申请号：US14248135

申请日：2014-04-08

Applicant: Genentech, Inc.

Inventor： Glynn Dennis, Jr. ,  Flavius Martin ,  Michael J. Townsend

IPC: G01N33/53 ,  C12Q1/68 ,  A61K38/16 ,  G01N33/564 ,  C07K16/28

CPC classification number: C12Q1/6837 ,  A61K38/16 ,  C07K16/2887 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/564 ,  G01N2800/102 ,  G01N2800/52 ,  Y02A50/463

Abstract: Methods of identifying, diagnosing, and prognosing rheumatoid arthritis are provided, as well as methods of treating rheumatoid arthritis. Also provided are methods for identifying effective rheumatoid arthritis therapeutic agents and predicting responsiveness to rheumatoid arthritis therapeutic agents.

公开(公告)号：US09139878B2

公开(公告)日：2015-09-22

申请号：US13794717

申请日：2013-03-11

Applicant: Genentech, Inc.

Inventor： Alexander Abbas ,  Barmak Modrek ,  Michael J. Townsend

IPC: C12Q1/68 ,  C40B40/04 ,  A61K39/395 ,  A61K39/00 ,  G06F19/18

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  G06F19/18 ,  Y02A90/24

Abstract: This invention provides methods and compositions useful for detecting autoimmune disorders.

Abstract translation: 本发明提供了可用于检测自身免疫性疾病的方法和组合物。