公开(公告)号：US10533058B2

公开(公告)日：2020-01-14

申请号：US15104388

申请日：2014-12-16

Applicant: GENENTECH INC. ,  MEDIMMUNE LIMITED

Inventor： John Flygare ,  Janet Gunzner-Toste ,  Thomas Pillow ,  Brian Safina ,  Vishal Verma ,  Binqing Wei ,  Guiling Zhao ,  Leanna Staben ,  Philip Wilson Howard ,  Luke Masterson

IPC: A61K47/68 ,  A61K31/5517 ,  C07K16/30 ,  C07K16/28

Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, pharmaceutical compositions containing them, and to their use in therapy for the prevention treatment of cancer.

公开(公告)号：US11692043B2

公开(公告)日：2023-07-04

申请号：US16696455

申请日：2019-11-26

Applicant: GENENTECH INC. ,  MEDIMMUNE LIMITED

Inventor： John Flygare ,  Janet Gunzner-Toste ,  Thomas Pillow ,  Brian Safina ,  Vishal Verma ,  Binqing Wei ,  Guiling Zhao ,  Leanna Staben ,  Philip Wilson Howard ,  Luke Masterson

IPC: C07K16/30 ,  A61K47/68 ,  A61K31/5517 ,  C07K16/28

CPC classification number: C07K16/3092 ,  A61K31/5517 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6867 ,  A61K47/6869 ,  A61K47/6889 ,  C07K16/2851 ,  C07K16/30 ,  C07K16/3061 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56

Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof pharmaceutical compositions containing them, and to their use in therapy for the prevention treatment of cancer.

公开(公告)号：US11155557B2

公开(公告)日：2021-10-26

申请号：US16452058

申请日：2019-06-25

Applicant: Genentech, Inc.

Inventor： F. Anthony Romero ,  Mark Zak ,  Guiling Zhao ,  Paul Gibbons ,  Wei Li ,  Yun-Xing Cheng ,  Po-Wai Yuen ,  Limin Cheng

IPC: C07D487/04 ,  C07D498/10

Abstract: Compounds of Formula (IA), or a pharmaceutically acceptable salt thereof, and methods of use as Janus kinase inhibitors are described herein.

公开(公告)号：US20190083643A1

公开(公告)日：2019-03-21

申请号：US16150623

申请日：2018-10-03

Applicant: Genentech, Inc.

Inventor： Ho Huat Lee ,  Moana Tercel ,  John A. Flygare ,  Janet Gunzner-Toste ,  Thomas H. Pillow ,  Brian Safina ,  Leanna Staben ,  Vishal Verma ,  BinQing Wei ,  Guiling Zhao

IPC: A61K47/68 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.

公开(公告)号：US08802674B2

公开(公告)日：2014-08-12

申请号：US13712015

申请日：2012-12-12

Applicant: Genentech, Inc.

Inventor： Charles Baker-Glenn ,  Daniel Jon Burdick ,  Mark Chambers ,  Bryan K. Chan ,  Huifen Chen ,  Anthony Estrada ,  Janet Gunzner-Tate ,  Daniel Shore ,  Zachary Kevin Sweeney ,  Shumei Wang ,  Guiling Zhao

IPC: A61K31/535 ,  C07D413/14 ,  C07D498/06 ,  C07D473/16 ,  C07D403/14 ,  C07D413/12

CPC classification number: C07D413/14 ,  C07D403/14 ,  C07D413/12 ,  C07D473/16 ,  C07D498/06 ,  C07D498/08

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

Abstract translation: 式I化合物或其药学上可接受的盐，其中m，n。 X，R 1，R 2，R 3，R 5，R 6和R 7如本文所定义。 还公开了制备化合物和使用该化合物治疗与LRRK2受体（例如帕金森病）相关的疾病的方法。

公开(公告)号：US11485745B2

公开(公告)日：2022-11-01

申请号：US16944581

申请日：2020-07-31

Applicant: Valo Health, Inc. ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Peter Dragovich ,  Xiongcai Liu ,  Snahel Patel ,  Po-Wai Yuen ,  Mark Zak ,  Guiling Zhao ,  Yamin Zhang ,  Xiaozhang Zheng

IPC: C07D519/00 ,  C07D495/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  A61K31/438 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/513

Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US10975095B2

公开(公告)日：2021-04-13

申请号：US16034207

申请日：2018-07-12

Applicant: Genentech, Inc.

Inventor： Snahel Patel ,  Gregory Hamilton ,  Guiling Zhao ,  Huifen Chen ,  Blake Daniels ,  Craig Stivala

IPC: C07D498/04 ,  C07D487/04 ,  A61P25/16 ,  A61P25/28 ,  C07D235/12 ,  C07D471/04 ,  A61P17/06 ,  A61P21/00 ,  A61P19/02 ,  A61P1/00

Abstract: The invention provides novel compounds having the general formula I: wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

公开(公告)号：US10933036B2

公开(公告)日：2021-03-02

申请号：US15828271

申请日：2017-11-30

Applicant: Genentech, Inc.

Inventor： Snahel Patel ,  Gregory Hamilton ,  Guiling Zhao ,  Huifen Chen

IPC: C07D471/04 ,  A61K31/16 ,  C07D519/00 ,  C07D487/04 ,  A61P9/00 ,  C07D491/048 ,  C07D491/04 ,  A61P9/10 ,  A61P43/00 ,  A61P29/00 ,  A61K31/396 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/416 ,  A61K31/4196 ,  A61K31/44 ,  A61K31/5383

Abstract: The invention provides novel compounds having the general formula I: wherein R1, R2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.

公开(公告)号：US09999681B2

公开(公告)日：2018-06-19

申请号：US15181825

申请日：2016-06-14

Applicant: Genentech, Inc.

Inventor： John Flygare ,  Janet Gunzner-Toste ,  Thomas Pillow ,  Brian Safina ,  Vishal Verma ,  Binqing Wei ,  Guiling Zhao ,  Leanna Staben

IPC: C07K16/30 ,  C07K16/28 ,  A61K47/48 ,  A61K47/68

CPC classification number: A61K47/6803 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6889 ,  C07K16/28 ,  C07K16/2851 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/76

Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.

公开(公告)号：US20170008877A1

公开(公告)日：2017-01-12

申请号：US15200058

申请日：2016-07-01

Applicant: Genentech, Inc.

Inventor： Snahel PATEL ,  Gregory HAMILTON ,  Craig Stivala ,  Huifen Chen ,  Guiling Zhao

IPC: C07D403/12 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  C07D498/04 ,  C07D491/044 ,  C07D413/14 ,  C07D491/048 ,  C07D413/12 ,  C07D491/052

CPC classification number: C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  C07D491/052 ,  C07D491/10 ,  C07D495/04 ,  C07D498/04 ,  C07D519/00

Abstract: The invention provides novel compounds having the general formula I: wherein R1, X, Z1, L, n, the A ring, the B ring, and the C ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.

Abstract translation: 其中R1，X，Z1，L，n，A环，B环和C环如本文所述，包括该化合物的药物组合物和使用该化合物的方法。