公开(公告)号：US20240279322A1

公开(公告)日：2024-08-22

申请号：US18420510

申请日：2024-01-23

Applicant: Genentech, Inc.

Inventor： Wei-Ching Liang ,  Joseph R. Arron ,  Daryle DePianto ,  Wendy Green Halpern ,  WeiYu Lin ,  Patrick J. Lupardus ,  Thirumalai Rajan Ramalingam ,  Dhaya Seshasayee ,  Tianhe Sun ,  Tulika Tyagi ,  Jia Wu ,  Yan Wu ,  Jian Ping Yin

IPC: C07K16/22 ,  A61K39/00 ,  A61K39/395 ,  A61P11/00 ,  C07K16/46

CPC classification number: C07K16/22 ,  A61P11/00 ,  C07K16/464 ,  A61K39/39533 ,  A61K39/39566 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention provides isoform-selective anti-TGFβ antibodies and methods of using the same. In particular, isoform-selective anti-TGFβ2, anti-TGFβ3, and anti-TGFβ2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGFβ-related disorders.

公开(公告)号：US11919948B2

公开(公告)日：2024-03-05

申请号：US17205663

申请日：2021-03-18

Applicant: Genentech, Inc.

Inventor： Wei-Ching Liang ,  Joseph R. Arron ,  Daryle Depianto ,  Wendy Green Halpern ,  WeiYu Lin ,  Patrick J. Lupardus ,  Thirumalai Rajan Ramalingam ,  Dhaya Seshasayee ,  Tianhe Sun ,  Tulika Tyagi ,  Jia Wu ,  Yan Wu ,  Jian Ping Yin

IPC: C07K16/22 ,  A61K39/00 ,  A61K39/395 ,  A61P11/00 ,  C07K16/46

CPC classification number: C07K16/22 ,  A61P11/00 ,  C07K16/464 ,  A61K39/39533 ,  A61K39/39566 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention provides isoform-selective anti-TGFβ antibodies and methods of using the same. In particular, isoform-selective anti-TGFβ2, anti-TGFβ3, and anti-TGFβ2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGFβ-related disorders.