公开(公告)号：US20160230226A1

公开(公告)日：2016-08-11

申请号：US14493649

申请日：2014-09-23

Applicant: GENENTECH, INC.

Inventor： Alexander R. Abbas ,  Joseph R. Arron ,  Sanjay Chandriani ,  Guiquan Jia ,  Nicholas J.I. Lewin-Koh ,  Daryle DePianto

IPC: C12Q1/68 ,  G01N33/68 ,  C07K16/24

CPC classification number: C12Q1/6883 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K16/244 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2333/521 ,  G01N2333/775 ,  G01N2333/96494 ,  G01N2800/12 ,  G01N2800/52

Abstract: Compositions, kits and methods for assessing the prognosis of idiopathic pulmonary fibrosis in patients are provided. In addition, compositions, kits and methods for diagnosing subtypes of idiopathic pulmonary fibrosis are provided. Also provided are methods for treating idiopathic pulmonary fibrosis.

Abstract translation: 提供了用于评估患者特发性肺纤维化预后的组合物，试剂盒和方法。 此外，提供了用于诊断特发性肺纤维化亚型的组合物，试剂盒和方法。 还提供了治疗特发性肺纤维化的方法。

公开(公告)号：US20240279322A1

公开(公告)日：2024-08-22

申请号：US18420510

申请日：2024-01-23

Applicant: Genentech, Inc.

Inventor： Wei-Ching Liang ,  Joseph R. Arron ,  Daryle DePianto ,  Wendy Green Halpern ,  WeiYu Lin ,  Patrick J. Lupardus ,  Thirumalai Rajan Ramalingam ,  Dhaya Seshasayee ,  Tianhe Sun ,  Tulika Tyagi ,  Jia Wu ,  Yan Wu ,  Jian Ping Yin

IPC: C07K16/22 ,  A61K39/00 ,  A61K39/395 ,  A61P11/00 ,  C07K16/46

CPC classification number: C07K16/22 ,  A61P11/00 ,  C07K16/464 ,  A61K39/39533 ,  A61K39/39566 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention provides isoform-selective anti-TGFβ antibodies and methods of using the same. In particular, isoform-selective anti-TGFβ2, anti-TGFβ3, and anti-TGFβ2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGFβ-related disorders.