公开(公告)号：US20240383915A1

公开(公告)日：2024-11-21

申请号：US18554438

申请日：2022-04-06

Applicant: Genentech, Inc.

Inventor： Lewis J. GAZZARD ,  Samantha Alyson GREEN ,  Elizabeth H. KELLEY ,  Matthew Leo LANDRY ,  Sushant MALHOTRA ,  Benjamin David RAVETZ ,  Michael SIU ,  Jack Alexander TERRETT ,  BinQing WEI ,  Steven DO ,  Yun-Xing CHENG ,  Limin CHENG ,  Jianfeng XIN ,  Mingtao HE ,  Guosheng WU ,  Yinlei SUN ,  Cheng SHAO ,  Aijun LU ,  Yulai ZHANG

IPC: C07D498/04 ,  A61K31/553 ,  A61K45/06 ,  C07D519/00

Abstract: Provided herein are acyclic oxazepinyl compounds useful in the treatment on cancers.

公开(公告)号：US20200171029A1

公开(公告)日：2020-06-04

申请号：US16568130

申请日：2019-09-11

Applicant: Genentech, Inc.

Inventor： Anthony ESTRADA ,  Alan G. OLIVERO ,  Snahel PATEL ,  Michael SIU ,  Joseph LYSSIKATOS

IPC: A61K31/506 ,  C07D471/08 ,  A61K45/06 ,  A61K31/5386 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/55 ,  A61K35/30 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/18 ,  C07D487/08 ,  C07D491/08 ,  C07D495/08 ,  C07D519/00 ,  A61K31/553 ,  C07D417/14 ,  C07D487/14 ,  C07D487/18 ,  A61K31/444

Abstract: The present invention provides for compounds of Formula I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula all have the meaning as defined herein.

公开(公告)号：US20240391930A1

公开(公告)日：2024-11-28

申请号：US18670537

申请日：2024-05-21

Applicant: GENENTECH, INC. ,  CONVELO THERAPEUTICS, INC.

Inventor： Marie-Gabrielle BRAUN ,  Georgette CASTANEDO ,  William VERNIER ,  Matthew VOLGRAF ,  Michael SIU ,  James Guy BREITENBUCHER

IPC: C07D495/10 ,  A61K31/4155 ,  A61K31/4196 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506

Abstract: The subject matter described herein is directed to myelin-promoting compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for the treatment of disorders, such as myelin-related disorders.

公开(公告)号：US20220281893A1

公开(公告)日：2022-09-08

申请号：US17666350

申请日：2022-02-07

Applicant: Genentech, Inc.

Inventor： Lewis J. GAZZARD ,  Samantha Alyson GREEN ,  Matthew Leo LANDRY ,  Sushant MALHOTRA ,  Michael SIU ,  Steven DO ,  Yun-Xing CHENG ,  Limin CHENG ,  Jianfeng XIN ,  Mingtao HE

IPC: C07D498/22 ,  C07D519/00 ,  A61K31/553 ,  A61K45/06 ,  A61P35/00

Abstract: Provided herein are tetracyclic oxazepinyl compounds useful in the treatment on cancers.