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公开(公告)号:US20190263786A1
公开(公告)日:2019-08-29
申请号:US16283451
申请日:2019-02-22
Applicant: GENENTECH, INC.
Inventor: Daniel SUTHERLIN , Steven MCKERRALL , Kwong Wah LAI , Zhiguo LIU , Wenfeng LIU , Ramsay BEVERIDGE , Jean-Philippe LECLERC , Alexandre LEMIRE , Liang ZHAO , Claudio STURINO
IPC: C07D403/12 , C07D233/96 , C07D401/12 , C07D401/14 , C07D263/52 , C07D305/06 , A61P17/04
Abstract: The invention provides a compound as described herein or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号:US20230203062A1
公开(公告)日:2023-06-29
申请号:US18057742
申请日:2022-11-21
Applicant: Genentech, Inc.
Inventor: Jason Robert ZBIEG , Paul Powell BEROZA , Vishal Anil VERMA , Bing-Yan ZHU , Ramsay BEVERIDGE , Liang ZHAO , Melissa LEBLANC , Lisa Marie BARTON , Bryan Ka Ip CHAN , Samir BOUAYAD-GERVAIS , Anwesha DEY , Marie Anne EVANGELISTA , Russell Tyler SMITH
IPC: C07D513/04 , C07D307/81 , C07D413/04 , C07D491/052 , C07D471/04 , C07D239/74 , C07D491/048 , C07D498/04 , C07D215/12 , C07D405/08 , C07D403/06 , C07D235/14 , C07D487/04 , C07D241/42 , C07D263/56
CPC classification number: C07D513/04 , C07D307/81 , C07D413/04 , C07D491/052 , C07D471/04 , C07D239/74 , C07D491/048 , C07D498/04 , C07D215/12 , C07D405/08 , C07D403/06 , C07D235/14 , C07D487/04 , C07D241/42 , C07D263/56
Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.
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公开(公告)号:US20220081423A1
公开(公告)日:2022-03-17
申请号:US17331164
申请日:2021-05-26
Applicant: GENENTECH, INC.
Inventor: Daniel SUTHERLIN , Steven MCKERRALL , Kwong Wah LAI , Zhiguo LIU , Wenfeng LIU , Ramsay BEVERIDGE , Jean-Philippe LECLERC , Alexandre LEMIRE , Liang ZHAO , Claudio STURINO
IPC: C07D403/12 , C07D233/96 , C07D401/12 , A61P17/04 , C07D263/52 , C07D305/06 , C07D401/14 , A61K31/506 , A61K31/538 , C07D413/12 , C07B59/00 , A61K31/63 , A61K45/06 , C07D239/69 , A61K31/505
Abstract: The invention provides benzene sulfonamides and pharmaceutically acceptable salt thereof that are useful as sodium channel blockers for the treatment of, for example, pain. The following compound is illustrative:
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