公开(公告)号：US20210214336A1

公开(公告)日：2021-07-15

申请号：US17056325

申请日：2019-05-21

Applicant: GENENTECH, INC.

Inventor： Steven MCKERRALL ,  Ramsay BEVERIDGE ,  Kwong Wah LAI ,  Philippe BERGERON

IPC: C07D401/12 ,  A61P17/04 ,  A61K9/00 ,  A61P29/00

Abstract: The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables Y1-Y6, X, Z, Z1, Z2, R2-R3, and R6 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. The compounds have sodium channel blocking activity that are useful for treating sodium channel-mediated diseases, in particular for treating pain

公开(公告)号：US20250115576A1

公开(公告)日：2025-04-10

申请号：US18985502

申请日：2024-12-18

Applicant: Genentech, Inc.

Inventor： Steven MCKERRALL ,  Ramsay BEVERIDGE ,  Kwong Wah LAI ,  Philippe BERGERON

IPC: C07D401/12 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/14 ,  C07D413/12

Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables Y1-Y6, X, Z, Z1, Z2, R2-R3, and R6 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20230203062A1

公开(公告)日：2023-06-29

申请号：US18057742

申请日：2022-11-21

Applicant: Genentech, Inc.

Inventor： Jason Robert ZBIEG ,  Paul Powell BEROZA ,  Vishal Anil VERMA ,  Bing-Yan ZHU ,  Ramsay BEVERIDGE ,  Liang ZHAO ,  Melissa LEBLANC ,  Lisa Marie BARTON ,  Bryan Ka Ip CHAN ,  Samir BOUAYAD-GERVAIS ,  Anwesha DEY ,  Marie Anne EVANGELISTA ,  Russell Tyler SMITH

IPC: C07D513/04 ,  C07D307/81 ,  C07D413/04 ,  C07D491/052 ,  C07D471/04 ,  C07D239/74 ,  C07D491/048 ,  C07D498/04 ,  C07D215/12 ,  C07D405/08 ,  C07D403/06 ,  C07D235/14 ,  C07D487/04 ,  C07D241/42 ,  C07D263/56

CPC classification number: C07D513/04 ,  C07D307/81 ,  C07D413/04 ,  C07D491/052 ,  C07D471/04 ,  C07D239/74 ,  C07D491/048 ,  C07D498/04 ,  C07D215/12 ,  C07D405/08 ,  C07D403/06 ,  C07D235/14 ,  C07D487/04 ,  C07D241/42 ,  C07D263/56

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US20220081423A1

公开(公告)日：2022-03-17

申请号：US17331164

申请日：2021-05-26

Applicant: GENENTECH, INC.

Inventor： Daniel SUTHERLIN ,  Steven MCKERRALL ,  Kwong Wah LAI ,  Zhiguo LIU ,  Wenfeng LIU ,  Ramsay BEVERIDGE ,  Jean-Philippe LECLERC ,  Alexandre LEMIRE ,  Liang ZHAO ,  Claudio STURINO

IPC: C07D403/12 ,  C07D233/96 ,  C07D401/12 ,  A61P17/04 ,  C07D263/52 ,  C07D305/06 ,  C07D401/14 ,  A61K31/506 ,  A61K31/538 ,  C07D413/12 ,  C07B59/00 ,  A61K31/63 ,  A61K45/06 ,  C07D239/69 ,  A61K31/505

Abstract: The invention provides benzene sulfonamides and pharmaceutically acceptable salt thereof that are useful as sodium channel blockers for the treatment of, for example, pain. The following compound is illustrative:

公开(公告)号：US20250074881A1

公开(公告)日：2025-03-06

申请号：US18823182

申请日：2024-09-03

Applicant: Genentech, Inc.

Inventor： Jason Robert ZBIEG ,  Russell Tyler SMITH ,  Paul Powell BEROZA ,  Vishal Anil VERMA ,  Bing-Yan ZHU ,  Ramsay BEVERIDGE ,  Lisa Marie BARTON ,  Bryan Ka Ip CHAN ,  Curtis COLWELL ,  Samir BOUAYAD-GERVAIS ,  Anwesha DEY ,  Marie Anne EVANGELISTA

IPC: C07D231/56 ,  C07D471/04 ,  C07F9/09

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US20240239766A1

公开(公告)日：2024-07-18

申请号：US18584298

申请日：2024-02-22

Applicant: Genentech, Inc.

Inventor： Steven John MCKERRALL ,  Daniel Fred ORTWINE ,  Philippe BERGERON ,  Ramsay BEVERIDGE ,  Elise GHIRO ,  Kwong Wah LAI ,  Guqin SHI

IPC: C07D401/12 ,  A61K31/454 ,  A61K31/506 ,  A61P17/04 ,  A61P29/00 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12

CPC classification number: C07D401/12 ,  A61K31/454 ,  A61K31/506 ,  A61P17/04 ,  A61P29/00 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12

Abstract: The invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein Z1, Z2, R3-R8, RA, ring A, and n have the meanings described herein, and compositions containing such compounds and methods for using such compounds and compositions for the treatment of pain.

公开(公告)号：US20190263786A1

公开(公告)日：2019-08-29

申请号：US16283451

申请日：2019-02-22

Applicant: GENENTECH, INC.

Inventor： Daniel SUTHERLIN ,  Steven MCKERRALL ,  Kwong Wah LAI ,  Zhiguo LIU ,  Wenfeng LIU ,  Ramsay BEVERIDGE ,  Jean-Philippe LECLERC ,  Alexandre LEMIRE ,  Liang ZHAO ,  Claudio STURINO

IPC: C07D403/12 ,  C07D233/96 ,  C07D401/12 ,  C07D401/14 ,  C07D263/52 ,  C07D305/06 ,  A61P17/04

Abstract: The invention provides a compound as described herein or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and methods for using such compounds and compositions.