公开(公告)号：US20230203062A1

公开(公告)日：2023-06-29

申请号：US18057742

申请日：2022-11-21

Applicant: Genentech, Inc.

Inventor： Jason Robert ZBIEG ,  Paul Powell BEROZA ,  Vishal Anil VERMA ,  Bing-Yan ZHU ,  Ramsay BEVERIDGE ,  Liang ZHAO ,  Melissa LEBLANC ,  Lisa Marie BARTON ,  Bryan Ka Ip CHAN ,  Samir BOUAYAD-GERVAIS ,  Anwesha DEY ,  Marie Anne EVANGELISTA ,  Russell Tyler SMITH

IPC: C07D513/04 ,  C07D307/81 ,  C07D413/04 ,  C07D491/052 ,  C07D471/04 ,  C07D239/74 ,  C07D491/048 ,  C07D498/04 ,  C07D215/12 ,  C07D405/08 ,  C07D403/06 ,  C07D235/14 ,  C07D487/04 ,  C07D241/42 ,  C07D263/56

CPC classification number: C07D513/04 ,  C07D307/81 ,  C07D413/04 ,  C07D491/052 ,  C07D471/04 ,  C07D239/74 ,  C07D491/048 ,  C07D498/04 ,  C07D215/12 ,  C07D405/08 ,  C07D403/06 ,  C07D235/14 ,  C07D487/04 ,  C07D241/42 ,  C07D263/56

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US20250074881A1

公开(公告)日：2025-03-06

申请号：US18823182

申请日：2024-09-03

Applicant: Genentech, Inc.

Inventor： Jason Robert ZBIEG ,  Russell Tyler SMITH ,  Paul Powell BEROZA ,  Vishal Anil VERMA ,  Bing-Yan ZHU ,  Ramsay BEVERIDGE ,  Lisa Marie BARTON ,  Bryan Ka Ip CHAN ,  Curtis COLWELL ,  Samir BOUAYAD-GERVAIS ,  Anwesha DEY ,  Marie Anne EVANGELISTA

IPC: C07D231/56 ,  C07D471/04 ,  C07F9/09

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US20210188775A1

公开(公告)日：2021-06-24

申请号：US17249457

申请日：2021-03-02

Applicant: Genentech, Inc.

Inventor： Christian CUNNINGHAM ,  Paul Powell BEROZA ,  James John CRAWFORD ,  Wendy Lee ,  Olivier RENE ,  Jason Robert ZBIEG ,  Jiangpeng LIAO ,  Tao WANG ,  Chen YU

IPC: C07D213/76 ,  C07C311/08 ,  C07C303/40 ,  C07C235/46 ,  C07C231/14 ,  C07D213/82 ,  C07D209/08 ,  C07D237/24

Abstract: The invention is concerned with the compounds of formula (I) and formula (II): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of using the compounds of formula (I) and formula (II) as well as pharmaceutical compositions containing such compounds. The compounds are useful in treating diseases and conditions mediated by TEAD, such as cancer.