公开(公告)号：US20220064286A1

公开(公告)日：2022-03-03

申请号：US17526338

申请日：2021-11-15

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN ,  Robert J. JOHNSTON ,  Yan WU ,  Wei-Ching LIANG ,  Patrick LUPARDUS ,  Mahesh YADAV ,  Dhaya SESHASAYEE ,  Meredith HAZEN

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  A61K38/17

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

公开(公告)号：US20210253693A1

公开(公告)日：2021-08-19

申请号：US17244682

申请日：2021-04-29

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN ,  Robert J. JOHNSTON ,  Yan WU ,  Wei-Ching LIANG ,  Patrick LUPARDUS ,  Mahesh YADAV ,  Dhaya SESHASAYEE ,  Meredith HAZEN

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  A61K38/17

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

公开(公告)号：US20210032328A1

公开(公告)日：2021-02-04

申请号：US17064464

申请日：2020-10-06

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN ,  Robert J. JOHNSTON ,  Yan WU ,  Wei-Ching LIANG ,  Patrick LUPARDUS ,  Mahesh YADAV ,  Dhaya SESHASAYEE ,  Meredith HAZEN

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  A61K38/17

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

公开(公告)号：US20190119376A1

公开(公告)日：2019-04-25

申请号：US15994583

申请日：2018-05-31

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN ,  Robert J. JOHNSTON ,  Yan WU ,  Wei-Ching LIANG ,  Patrick LUPARDUS ,  Mahesh YADAV ,  Dhaya SESHASAYEE ,  Meredith HAZEN

IPC: C07K16/28 ,  A61K45/06 ,  A61K38/17 ,  C07K16/30 ,  A61K39/395

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

公开(公告)号：US20180186875A1

公开(公告)日：2018-07-05

申请号：US15895741

申请日：2018-02-13

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN ,  Robert J. JOHNSTON ,  Yan WU ,  Wei-Ching LIANG ,  Patrick LUPARDUS ,  Mahesh YADAV ,  Dhaya SESHASAYEE ,  Meredith HAZEN

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  C07K16/30 ,  A61K38/17 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K38/177 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/70 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  Y02A50/466

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

公开(公告)号：US20240117037A1

公开(公告)日：2024-04-11

申请号：US18345587

申请日：2023-06-30

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN ,  Robert J. JOHNSTON ,  Yan WU ,  Wei-Ching LIANG ,  Patrick LUPARDUS ,  Mahesh YADAV ,  Dhaya SESHASAYEE ,  Meredith HAZEN

IPC: C07K16/28 ,  A61K38/17 ,  A61K39/395 ,  A61K45/06 ,  C07K16/30

CPC classification number: C07K16/28 ,  A61K38/177 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  C07K16/3061 ,  A61K2039/507 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

公开(公告)号：US20170088613A1

公开(公告)日：2017-03-30

申请号：US15274603

申请日：2016-09-23

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN ,  Robert J. JOHNSTON ,  Yan WU ,  Wei-Ching LIANG ,  Patrick LUPARDUS ,  Mahesh YADAV ,  Dhaya SESHASAYEE ,  Meredith HAZEN

IPC: C07K16/28 ,  A61K38/17 ,  A61K45/06 ,  C07K16/30 ,  A61K39/395

CPC classification number: C07K16/28 ,  A61K38/177 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/70 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  Y02A50/466

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

公开(公告)号：US20240418731A1

公开(公告)日：2024-12-19

申请号：US18762502

申请日：2024-07-02

Applicant: Genentech, Inc.

Inventor： Lelia DELAMARRE ,  Patrick LUPARDUS ,  Ira MELLMAN ,  Mahesh YADAV ,  Suchit JHUNJHUNWALA ,  Jennie LILL

IPC: G01N33/68 ,  A61K39/00 ,  C12Q1/6886 ,  G01N33/569

Abstract: The present disclosure provides methods of identifying a disease-specific immunogenic peptide through a series of selection steps. Immunogenic epitopes identified by methods of the present disclosure are applicable for use in peptide-based immunotherapy, preferably cancer therapy. Furthermore, the methods of the present disclosure may be performed in a high-throughput manner and serve as a means of personalized vaccine development and therapy. Also provided are compositions of immunogenic peptides as well as methods of treatment comprising said compositions.

公开(公告)号：US20230279102A1

公开(公告)日：2023-09-07

申请号：US18062956

申请日：2022-12-07

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN ,  Robert J. JOHNSTON ,  Yan WU ,  Wei-Ching LIANG ,  Patrick LUPARDUS ,  Mahesh YADAV ,  Dhaya SESHASAYEE ,  Meredith HAZEN

IPC: C07K16/28 ,  A61K38/17 ,  C07K16/30 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/28 ,  A61K38/177 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  C07K16/3061 ,  A61K2039/507 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/90 ,  C07K2317/94

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

公开(公告)号：US20220378910A1

公开(公告)日：2022-12-01

申请号：US17854649

申请日：2022-06-30

Applicant: Genentech, Inc. ,  BioNTech SE ,  Hoffmann-La Roche Inc.

Inventor： Lars MUELLER ,  Rachel Lubong SABADO ,  Mahesh YADAV ,  Jingbin ZHANG ,  Ugur SAHIN

IPC: A61K39/395 ,  A61K39/00 ,  A61K9/127 ,  A61P35/00 ,  C07K14/74 ,  C07K14/47 ,  C07H21/04 ,  C07H21/02

Abstract: The present disclosure provides methods for inducing neoepitope-specific CD8+ T cells in an individual or for inducing trafficking of neoepitope-specific CD8+ T cells to a tumor in an individual using an RNA vaccine or using an RNA vaccine in combination with a PD-1 axis binding antagonist. Also provided herein are PD-1 axis binding antagonists and RNA vaccines that include one or more polynucleotides encoding one or more neoepitopes resulting from cancer-specific somatic mutations present in a tumor specimen obtained from the individual for use in methods of inducing neoepitope-specific CD8+ T cells in an individual or for inducing trafficking of neoepitope-specific CD8+ T cells to a tumor in an individual.