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1.发明申请公开(公告)号：US20140363432A1
公开(公告)日：2014-12-11
申请号：US14137022
申请日：2013-12-20
Applicant: GENENTECH, INC.
Inventor： Nicholas Van Bruggen , Napoleone Ferrara
CPC classification number: C07K16/22 , A61K38/00 , A61K38/179 , A61K39/39533 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/10 , C07K14/71 , C07K16/18 , C07K16/24 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C12N9/96 , Y02A50/412
Abstract: The present invention provides vascular endothelial cell growth factor (VEGF) antagonists and methods of using VEGF antagonists. VEGF antagonists contemplated by the invention include VEGF antibodies and VEGF receptor fusion proteins. Methods of treating edema and stroke using VEGF antagonists are also provided.
Abstract translation: 本发明提供血管内皮细胞生长因子（VEGF）拮抗剂和使用VEGF拮抗剂的方法。 本发明考虑的VEGF拮抗剂包括VEGF抗体和VEGF受体融合蛋白。 还提供了使用VEGF拮抗剂治疗水肿和中风的方法。
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Patent Agency Ranking
公开(公告)号：US20190177390A1
公开(公告)日：2019-06-13
申请号：US16196936
申请日：2018-11-20
Applicant: Genentech, Inc.
Inventor： Justin Scheer , Wenjun Ouyang , Richard Vandlen , Philip E. Hass , Eric Gary Stefanich , Ganesh A. Kolumam , Xiaoting Wang , Jed Ross , Nicholas Van Bruggen , Wyne P. Lee
Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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3.发明授权公开(公告)号：US11136365B2
公开(公告)日：2021-10-05
申请号：US16196823
申请日：2018-11-20
Applicant: Genentech, Inc.
Inventor： Justin Scheer , Wenjun Ouyang , Richard Vandlen , Philip E. Hass , Eric Gary Stefanich , Ganesh A. Kolumam , Xiaoting Wang , Jed Ross , Nicholas Van Bruggen
Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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公开(公告)号：US20190233491A1
公开(公告)日：2019-08-01
申请号：US16128008
申请日：2018-09-11
Applicant: Genentech, Inc.
Inventor： Justin Scheer , Wenjun Ouyang , Richard Vandlen , Philip E. Hass , Eric Gary Stefanich , Ganesh A. Kolumam , Xiaoting Wang , Jed Ross , Nicholas Van Bruggen , Wyne P. Lee
CPC classification number: C07K14/54 , A61K38/00 , A61K38/20 , A61K47/38 , C07K16/2866 , C07K2319/30
Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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公开(公告)号：US10584155B2
公开(公告)日：2020-03-10
申请号：US15801867
申请日：2017-11-02
Applicant: Genentech, Inc.
Inventor： Justin Scheer , Wenjun Ouyang , Richard Vandlen , Philip E. Hass , Eric Gary Stefanich , Ganesh A. Kolumam , Xiaoting Wang , Jed Ross , Nicholas Van Bruggen , Wyne P. Lee
Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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公开(公告)号：US20190177387A1
公开(公告)日：2019-06-13
申请号：US16196743
申请日：2018-11-20
Applicant: Genentech, Inc.
Inventor： Justin Scheer , Wenjun Ouyang , Richard Vandlen , Philip E. Hass , Eric Gary Stefanich , Ganesh A. Kolumam , Xiaoting Wang , Jed Ross , Nicholas Van Bruggen , Wyne P. Lee
Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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