公开(公告)号：US11332507B2

公开(公告)日：2022-05-17

申请号：US16128008

申请日：2018-09-11

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Richard Vandlen ,  Philip E. Hass ,  Eric Gary Stefanich ,  Xiaoting Wang

IPC: A61K38/20 ,  C07K14/54 ,  C07K16/28 ,  A61K47/38 ,  A61K38/00

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US10544198B2

公开(公告)日：2020-01-28

申请号：US15454662

申请日：2017-03-09

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Richard Vandlen ,  Philip E. Hass ,  Eric Gary Stefanich ,  Xiaoting Wang ,  Ganesh A. Kolumam ,  Wyne P. Lee

IPC: C07K14/54 ,  C07K16/28 ,  A61K38/20 ,  A61K47/38 ,  A61K38/00

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US09815880B2

公开(公告)日：2017-11-14

申请号：US15217790

申请日：2016-07-22

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Richard Vandlen ,  Philip E. Hass ,  Eric Gary Stefanich ,  Xiaoting Wang

IPC: A61K38/20 ,  C07K14/54 ,  C07K16/28 ,  A61K47/38 ,  A61K38/00

CPC classification number: C07K14/54 ,  A61K38/00 ,  A61K38/20 ,  A61K47/38 ,  C07K16/2866 ,  C07K2319/30

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US10584155B2

公开(公告)日：2020-03-10

申请号：US15801867

申请日：2017-11-02

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Richard Vandlen ,  Philip E. Hass ,  Eric Gary Stefanich ,  Ganesh A. Kolumam ,  Xiaoting Wang ,  Jed Ross ,  Nicholas Van Bruggen ,  Wyne P. Lee

IPC: A61K38/20 ,  C07K14/54 ,  C07K16/28 ,  A61K47/38 ,  A61K38/00

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US20190177387A1

公开(公告)日：2019-06-13

申请号：US16196743

申请日：2018-11-20

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Richard Vandlen ,  Philip E. Hass ,  Eric Gary Stefanich ,  Ganesh A. Kolumam ,  Xiaoting Wang ,  Jed Ross ,  Nicholas Van Bruggen ,  Wyne P. Lee

IPC: C07K14/54 ,  A61K38/20 ,  A61K47/38 ,  C07K16/28

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US10160793B2

公开(公告)日：2018-12-25

申请号：US14214161

申请日：2014-03-14

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Richard Vandlen ,  Philip E. Hass ,  Eric Gary Stefanich ,  Xiaoting Wang

IPC: A61K38/20 ,  C07K14/54 ,  C07K16/28 ,  A61K47/38 ,  A61K38/00

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US20180016325A1

公开(公告)日：2018-01-18

申请号：US15718876

申请日：2017-09-28

Applicant: Genentech, Inc.

Inventor： Eric J. Brown ,  Martine Darwish ,  John Flygare ,  Wouter Hazenbos ,  Byoung Chul Lee ,  Sophie M. Lehar ,  Sanjeev Mariathasan ,  John Hiroshi Morisaki ,  Thomas H. Pillow ,  Leanna Staben ,  Richard Vandlen ,  Klaus Koefoed ,  Magnus Strandh ,  Peter S. Andersen

IPC: C07K16/12 ,  A61K45/06 ,  A61K39/40 ,  A61K31/4025 ,  A61K31/5386

CPC classification number: C07K16/1271 ,  A61K31/4025 ,  A61K31/5386 ,  A61K39/40 ,  A61K45/06 ,  A61K47/6809 ,  A61K47/6835 ,  C07K2317/21 ,  C07K2317/522 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/624 ,  C07K2317/92

Abstract: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.

公开(公告)号：US20180000962A1

公开(公告)日：2018-01-04

申请号：US15592072

申请日：2017-05-10

Applicant: Genentech, Inc.

Inventor： Charles W. Eigenbrot, JR. ,  Jagath Reddy Junutula ,  Henry Lowman ,  Helga E. Raab ,  Richard Vandlen

IPC: A61K47/68 ,  A61K45/06 ,  C07K16/00 ,  C07K16/32

CPC classification number: A61K47/6803 ,  A01K2267/0331 ,  A61K45/06 ,  A61K47/6817 ,  A61K47/6851 ,  A61K47/6889 ,  C07K16/00 ,  C07K16/32 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/624

Abstract: Antibodies are engineered by replacing one or more amino acids of a parent antibody with non cross-linked, highly reactive cysteine amino acids. Antibody fragments may also be engineered with one or more cysteine amino acids to form cysteine engineered antibody fragments (ThioFab). Methods of design, preparation, screening, and selection of the cysteine engineered antibodies are provided. Cysteine engineered antibodies (Ab), optionally with an albumin-binding peptide (ABP) sequence, are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered antibody-drug conjugates having Formula I: Ab-(L-D)p  I where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed.

公开(公告)号：US20160074529A1

公开(公告)日：2016-03-17

申请号：US14945716

申请日：2015-11-19

Applicant: GENENTECH, INC.

Inventor： Eric J. Brown ,  John Flygare ,  Wouter Hazenbos ,  Sophie M. Lehar ,  Sanjeev Mariathasan ,  John Hiroshi Morisaki ,  Thomas H. Pillow ,  Leanna Staben ,  Richard Vandlen ,  Klaus Koefoed ,  Magnus Strandh ,  Peter S. Andersen

IPC: A61K47/48 ,  A61K31/7048 ,  A61K31/4709 ,  A61K38/12 ,  A61K31/4375 ,  A61K31/4436 ,  A61K31/7056 ,  A61K31/439

CPC classification number: A61K47/6849 ,  A61K31/395 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/4436 ,  A61K31/4709 ,  A61K31/7048 ,  A61K31/7056 ,  A61K38/12 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6835 ,  A61K47/6851 ,  C07K16/1271 ,  C07K2317/21 ,  C07K2317/522 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/624 ,  C07K2317/92

Abstract: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.

公开(公告)号：US11155591B2

公开(公告)日：2021-10-26

申请号：US16196829

申请日：2018-11-20

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Eric Gary Stefanich ,  Richard Vandlen ,  Philip E. Hass ,  Xiaoting Wang

IPC: C07K14/54 ,  C07K16/28 ,  A61K38/20 ,  A61K47/38 ,  A61K38/00

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.