公开(公告)号：US20180291014A1

公开(公告)日：2018-10-11

申请号：US15939112

申请日：2018-03-28

申请人： GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

发明人： Phillipe BERGERON ,  Kristen BURFORD ,  Sultan CHOWDHURY ,  Christoph Martin DEHNHARDT ,  Thilo FOCKEN ,  Michael Edward GRIMWOOD ,  Abid HASAN ,  Kwong Wah LAI ,  Zhiguo LIU ,  Steven MCKERRALL ,  Teresa Phuongtram NGUYEN ,  Brian SAFINA ,  Daniel SUTHERLIN ,  Tao WANG

IPC分类号： C07D417/12 ,  C07D417/14 ,  C07D401/12 ,  C07D405/14 ,  C07D491/107 ,  A61P17/04

摘要： The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20210188775A1

公开(公告)日：2021-06-24

申请号：US17249457

申请日：2021-03-02

申请人： Genentech, Inc.

发明人： Christian CUNNINGHAM ,  Paul Powell BEROZA ,  James John CRAWFORD ,  Wendy Lee ,  Olivier RENE ,  Jason Robert ZBIEG ,  Jiangpeng LIAO ,  Tao WANG ,  Chen YU

IPC分类号： C07D213/76 ,  C07C311/08 ,  C07C303/40 ,  C07C235/46 ,  C07C231/14 ,  C07D213/82 ,  C07D209/08 ,  C07D237/24

摘要： The invention is concerned with the compounds of formula (I) and formula (II): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of using the compounds of formula (I) and formula (II) as well as pharmaceutical compositions containing such compounds. The compounds are useful in treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US20210171516A1

公开(公告)日：2021-06-10

申请号：US17031348

申请日：2020-09-24

申请人： GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

发明人： Philippe BERGERON ,  Kristen BURFORD ,  Sultan CHOWDHURY ,  Christoph Martin DEHNHARDT ,  Thilo FOCKEN ,  Michael Edward GRIMWOOD ,  Abid HASAN ,  Kwong Wah LAI ,  Zhiguo LIU ,  Steven MCKERRALL ,  Teresa Phuongtram NGUYEN ,  Brian Salvatore SAFINA ,  Daniel SUTHERLIN ,  Tao WANG

IPC分类号： C07D417/12 ,  C07D417/14 ,  A61P17/04 ,  C07D401/12 ,  C07D405/14 ,  C07D491/107

摘要： The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.