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公开(公告)号：US20160023209A1
公开(公告)日：2016-01-28
申请号：US14340693
申请日：2014-07-25
Applicant: General Electric Company
Inventor： Ralf Lenigk , Erin Jean Finehout , Xuefeng Wang
IPC: B01L3/00
CPC classification number: B01L3/502715 , B01L3/0258 , B01L3/0262 , B01L3/5023 , B01L3/561 , B01L2200/027 , B01L2200/10 , B01L2300/069 , B01L2300/0838 , B01L2300/0887 , B01L2300/12 , B01L2300/161 , B01L2300/165 , B01L2400/0406
Abstract: An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and an outlet for driving out the sample fluid. The device further comprises a third layer comprising an adhesive material such as a patterned adhesive material, and a flow path, wherein the third layer is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer and the outlet is in contact with the flow path of the third layer for allowing the sample fluid out from the integrated device.
Abstract translation: 提供了一种用于样品收集和转移的集成设备。 集成装置包括设置在第一层和第二层之间的毛细通道，其中第一层包括亲水层，该亲水层包括用于将样品流体接收到毛细通道的流体入口，其中毛细通道包括内表面和外表面 表面; 以及用于驱出样品流体的出口。 该装置还包括第三层，其包括诸如图案化粘合剂材料的粘合剂材料和流动路径，其中第三层设置在毛细管的外表面上，在相对于出口的确定位置处，使得毛细管 与第三层接触，并且出口与第三层的流动路径接触，以允许样品流体从集成装置流出。
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公开(公告)号：US20180299354A1
公开(公告)日：2018-10-18
申请号：US14035085
申请日：2013-09-24
Applicant: General Electric Company
Inventor： Ying Mao , Weston Blaine Griffin , Erin Jean Finehout , Ian Hart
IPC: G01N1/10 , G01N33/483
CPC classification number: A61B10/0045 , A61B10/0038 , A61B10/0096 , B01L3/5029 , B01L2300/043 , B01L2300/0822
Abstract: An assistive sample collection and storage assembly for collecting, transferring and storing a biological sample includes a sample collection device having a first portion and a second portion. The first portion is configured to receive a sample collection member. The assembly includes a sample storage device comprising a sample substrate configured to receive at least a portion of the biological sample from the sample collection member. The assembly is configured to exist in a first state and a second state. The sample collection member is disposed at a determined distance from the sample substrate in the first state. At least a portion of the sample collection member is in physical contact with at least a portion of the sample substrate in the second state. The sample collection member is configured to apply a determined amount of contact force between the collection member and the sample substrate in the second state of the assembly.
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公开(公告)号：US09901922B2
公开(公告)日：2018-02-27
申请号：US14340693
申请日：2014-07-25
Applicant: General Electric Company
Inventor： Ralf Lenigk , Erin Jean Finehout , Xuefeng Wang
CPC classification number: B01L3/502715 , B01L3/0258 , B01L3/0262 , B01L3/5023 , B01L3/561 , B01L2200/027 , B01L2200/10 , B01L2300/069 , B01L2300/0838 , B01L2300/0887 , B01L2300/12 , B01L2300/161 , B01L2300/165 , B01L2400/0406
Abstract: An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and an outlet for driving out the sample fluid. The device further comprises a third layer comprising an adhesive material such as a patterned adhesive material, and a flow path, wherein the third layer is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer and the outlet is in contact with the flow path of the third layer for allowing the sample fluid out from the integrated device.
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公开(公告)号：US10675622B2
公开(公告)日：2020-06-09
申请号：US15905226
申请日：2018-02-26
Applicant: General Electric Company
Inventor： Ralf Lenigk , Erin Jean Finehout , Xuefeng Wang
Abstract: An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and an outlet for driving out the sample fluid. The device further comprises a third layer comprising an adhesive material such as a patterned adhesive material and a flow path, wherein the third layer is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer and the outlet is in contact with the flow path of the third layer for allowing the sample fluid out from the integrated device.
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公开(公告)号：US10335078B2
公开(公告)日：2019-07-02
申请号：US14712290
申请日：2015-05-14
Applicant: General Electric Company
Inventor： Erik Leeming Kvam , Weston Blaine Griffin , Erin Jean Finehout , Ying Mao
IPC: A61B5/15 , A61B5/151 , C12Q1/6806
Abstract: A method for separating and collecting cell-free plasma by finger stick that minimizes contamination with genomic DNA from a donor. The method comprising placing a tourniquet on one of the digits of the donor's finger to apply pressure, lancing the digit to create an incision in the digit, and collecting blood from the incision from the incision site. The collected blood is placed on a separation membrane wherein the separation membrane is in contact with a collection membrane and both the separation and collection membrane are inserted into a substrate configured to provide overlap between the membranes. A kit and instructions for carrying out the method is also provided.
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Patent Agency Ranking
公开(公告)号：US10130258B2
公开(公告)日：2018-11-20
申请号：US14035085
申请日：2013-09-24
Applicant: General Electric Company
Inventor： Ying Mao , Weston Blaine Griffin , Erin Jean Finehout , Ian Hart
IPC: A61B5/00
Abstract: An assistive sample collection and storage assembly for collecting, transferring and storing a biological sample includes a sample collection device having a first portion and a second portion. The first portion is configured to receive a sample collection member. The assembly includes a sample storage device comprising a sample substrate configured to receive at least a portion of the biological sample from the sample collection member. The assembly is configured to exist in a first state and a second state. The sample collection member is disposed at a determined distance from the sample substrate in the first state. At least a portion of the sample collection member is in physical contact with at least a portion of the sample substrate in the second state. The sample collection member is configured to apply a determined amount of contact force between the collection member and the sample substrate in the second state of the assembly.
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公开(公告)号：US09714447B2
公开(公告)日：2017-07-25
申请号：US13970315
申请日：2013-08-19
Applicant: General Electric Company
Inventor： Erin Jean Finehout , Christopher Michael Puleo , Ralf Lenigk , Jason M. Nichols , John Nelson
IPC: C12Q1/68
CPC classification number: C12Q1/6844 , C12Q1/6816 , C12Q1/6851 , C12Q2565/137 , C12Q2565/625 , C12Q2527/113 , C12Q2565/133 , C12Q2545/114
Abstract: The present disclosure relates to characterization of biological samples by amplification detection in a porous substrate. By way of example, a porous substrate may include amplification reagents configured to provide a signal when released during amplification. When a sample is applied, amplification occurs as a wavefront from the application point, and the time that the wavefront reaches a distance on the porous substrate is related to an initial concentration of the sample applied. By detecting the distance traveled by the amplification products at one or more time points, an initial concentration of the sample may be estimated.
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公开(公告)号：US20180185843A1
公开(公告)日：2018-07-05
申请号：US15905226
申请日：2018-02-26
Applicant: General Electric Company
Inventor： Ralf Lenigk , Erin Jean Finehout , Xuefeng Wang
Abstract: An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and an outlet for driving out the sample fluid. The device further comprises a third layer comprising an adhesive material such as a patterned adhesive material and a flow path, wherein the third layer is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer and the outlet is in contact with the flow path of the third layer for allowing the sample fluid out from the integrated device.
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公开(公告)号：US20170203292A1
公开(公告)日：2017-07-20
申请号：US15326412
申请日：2015-07-20
Applicant: General Electric Company
Inventor： Ralf Lenigk , Erin Jean Finehout , Xuefeng Wang
CPC classification number: B01L3/5023 , A61B5/150343 , A61B5/150358 , B01L3/0258 , B01L3/0262 , B01L3/502715 , B01L3/561 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/16 , B01L2300/069 , B01L2300/0838 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , C12Q1/6806 , G01N1/14 , G01N2001/149
Abstract: An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface and an outlet for driving out the sample fluid. The device further comprises an interface assembly comprising: a third layer, a fourth layer, a fifth layer, and a flow path. The interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for driving out the sample fluid from the integrated device.
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公开(公告)号：US09480981B2
公开(公告)日：2016-11-01
申请号：US14341074
申请日：2014-07-25
Applicant: General Electric Company
Inventor： Ralf Lenigk , Erin Jean Finehout , Xuefeng Wang
CPC classification number: B01L3/5023 , A61B5/150343 , A61B5/150358 , B01L3/0258 , B01L3/0262 , B01L3/502715 , B01L3/561 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/16 , B01L2300/069 , B01L2300/0838 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , C12Q1/6806 , G01N1/14 , G01N2001/149
Abstract: An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface and an outlet for driving out the sample fluid. The device further comprises an interface assembly comprising: a third layer, a fourth layer, a fifth layer, and a flow path. The interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for driving out the sample fluid from the integrated device.
Abstract translation: 提供了一种用于样品收集和转移的集成设备。 集成装置包括设置在第一层和第二层之间的毛细通道，其中第一层包括亲水层，该亲水层包括用于将样品流体接收到毛细通道的流体入口，其中毛细通道包括内表面和外表面 表面和用于排出样品流体的出口。 该装置还包括界面组件，其包括：第三层，第四层，第五层和流路。 接口组件设置在毛细管的外表面上，在相对于出口的确定位置处，使得毛细管与接口组件的第三层接触并且出口与界面的流动路径接触 用于从集成装置排出样品流体的组件。
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