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公开(公告)号：US11938191B2
公开(公告)日：2024-03-26
申请号：US16864613
申请日：2020-05-01
发明人： Sean D. Monahan , Michael S. Declue , Pierrot Harvie , Russell N. Johnson , Amber E. Paschal , Mary G. Prieve , Debashish Roy , Charbel Diab , Michael E. Houston, Jr. , Anna Galperin , Maher Qabar
IPC分类号： A61K47/64 , A01K67/027 , A61K38/08 , A61K38/44 , A61K47/54 , A61K47/58 , A61K48/00 , C08F293/00 , C12N15/113 , C12N15/87
CPC分类号： A61K47/6455 , A01K67/027 , A61K38/08 , A61K38/44 , A61K47/549 , A61K47/58 , A61K48/0041 , C08F293/005 , C12N15/113 , C12N15/87 , A01K2207/05 , C12N2310/14 , C12N2310/351 , C12N2320/32 , C12Y113/12007
摘要： Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.
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公开(公告)号：US11684584B2
公开(公告)日：2023-06-27
申请号：US16475006
申请日：2017-12-29
发明人： Debashish Roy , Jean-Rene E. Ella-Menye , Sean D. Monahan , Pierrot Harvie , Anna Galperin , Michael E. Houston , Mary G. Prieve
CPC分类号： A61K9/5123 , A61K38/1816 , A61K47/34 , A61K48/0041 , A61K49/0093
摘要： Disclosed are branched PEG molecules, including branched PEG-lipids and branched-PEG proteins, as well as related compositions and methods for making branched PEG molecules. Also disclosed are related compositions, systems, and methods for in vivo delivery of therapeutic and diagnostic agents.
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公开(公告)号：US10660970B2
公开(公告)日：2020-05-26
申请号：US16543324
申请日：2019-08-16
发明人： Sean D. Monahan , Michael S. DeClue , Pierrot Harvie , Russell N. Johnson , Amber E. Paschal , Mary G. Prieve , Debashish Roy , Charbel Diab , Michael E. Houston, Jr. , Anna Galperin , Maher Qabar
IPC分类号： A61K47/64 , A01K67/027 , A61K38/08 , A61K38/44 , A61K47/54 , A61K47/58 , A61K48/00 , C08F293/00 , C12N15/113 , C12N15/87
摘要： Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.
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公开(公告)号：US10646582B2
公开(公告)日：2020-05-12
申请号：US15827793
申请日：2017-11-30
发明人： Sean D. Monahan , Michael S. DeClue , Pierrot Harvie , Russell N. Johnson , Amber E. Paschal , Mary G. Prieve , Debashish Roy , Charbel Diab , Michael E. Houston, Jr. , Anna Galperin , Maher Qabar
IPC分类号： A61K47/64 , A01K67/027 , A61K38/08 , A61K38/44 , A61K47/54 , A61K47/58 , A61K48/00 , C08F293/00 , C12N15/113 , C12N15/87
摘要： Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.
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