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公开(公告)号：US11938191B2
公开(公告)日：2024-03-26
申请号：US16864613
申请日：2020-05-01
发明人： Sean D. Monahan , Michael S. Declue , Pierrot Harvie , Russell N. Johnson , Amber E. Paschal , Mary G. Prieve , Debashish Roy , Charbel Diab , Michael E. Houston, Jr. , Anna Galperin , Maher Qabar
IPC分类号： A61K47/64 , A01K67/027 , A61K38/08 , A61K38/44 , A61K47/54 , A61K47/58 , A61K48/00 , C08F293/00 , C12N15/113 , C12N15/87
CPC分类号： A61K47/6455 , A01K67/027 , A61K38/08 , A61K38/44 , A61K47/549 , A61K47/58 , A61K48/0041 , C08F293/005 , C12N15/113 , C12N15/87 , A01K2207/05 , C12N2310/14 , C12N2310/351 , C12N2320/32 , C12Y113/12007
摘要： Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.
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2.发明授权公开(公告)号：US11219634B2
公开(公告)日：2022-01-11
申请号：US15545302
申请日：2016-01-21
IPC分类号： A61K31/7105 , A61K9/00 , A61K47/18 , A61K47/32 , A61K9/127 , A61K9/51 , C08F293/00 , A61K48/00 , A61K31/407 , A61K31/5365 , A61K31/704 , A61K31/7048 , A61K31/4745 , A61K31/47 , A61K31/475 , A61K31/40 , A61K9/107
摘要： Disclosed are methods for delivering a therapeutic or diagnostic agent to the cytosol of a cell in a subject. The disclosed methods generally include administering to the subject an effective amount of a lipid nanoparticle comprising the therapeutic or diagnostic agent and an effective amount of a membrane-destabilizing polymer. Also disclosed are related compositions and delivery systems.
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公开(公告)号：US10660970B2
公开(公告)日：2020-05-26
申请号：US16543324
申请日：2019-08-16
发明人： Sean D. Monahan , Michael S. DeClue , Pierrot Harvie , Russell N. Johnson , Amber E. Paschal , Mary G. Prieve , Debashish Roy , Charbel Diab , Michael E. Houston, Jr. , Anna Galperin , Maher Qabar
IPC分类号： A61K47/64 , A01K67/027 , A61K38/08 , A61K38/44 , A61K47/54 , A61K47/58 , A61K48/00 , C08F293/00 , C12N15/113 , C12N15/87
摘要： Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.
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公开(公告)号：US10646582B2
公开(公告)日：2020-05-12
申请号：US15827793
申请日：2017-11-30
发明人： Sean D. Monahan , Michael S. DeClue , Pierrot Harvie , Russell N. Johnson , Amber E. Paschal , Mary G. Prieve , Debashish Roy , Charbel Diab , Michael E. Houston, Jr. , Anna Galperin , Maher Qabar
IPC分类号： A61K47/64 , A01K67/027 , A61K38/08 , A61K38/44 , A61K47/54 , A61K47/58 , A61K48/00 , C08F293/00 , C12N15/113 , C12N15/87
摘要： Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.
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