公开(公告)号：US20210151122A1

公开(公告)日：2021-05-20

申请号：US17086850

申请日：2020-11-02

申请人： Genomic Health, Inc.

发明人： Steven SHAK ,  George Andrew WATSON ,  Michael R. CRAGER ,  Tara MADDALA ,  Margarita LOPATIN ,  Audrey GODDARD ,  Dejan KNEZEVIC ,  Christer SVEDMAN

IPC分类号： G16B20/00 ,  G16C99/00 ,  C12Q1/6886 ,  G16H50/30

摘要： The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence.

公开(公告)号：US20230374604A1

公开(公告)日：2023-11-23

申请号：US18130547

申请日：2023-04-04

申请人： Genomic Health, Inc.

发明人： Margarita LOPATIN ,  Athanasios TSIATIS ,  Christopher N. SILK ,  David P. MILLER ,  Michael R. CRAGER ,  Phillip FEBBO ,  Dejan KNEZEVIC

IPC分类号： C12Q1/6886 ,  A61P35/00

CPC分类号： C12Q1/6886 ,  A61P35/00 ,  C12Q2600/106 ,  C12Q2600/154 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/7028

摘要： The present disclosure relates to methods of monitoring bladder cancer patients and analyzing patient samples for presence of methylated DNA and optionally particular gene mutations. In some embodiments, analysis results are correlated with clinical outcome measures such as risk of bladder cancer recurrence.

公开(公告)号：US20200263257A1

公开(公告)日：2020-08-20

申请号：US16784696

申请日：2020-02-07

申请人： GENOMIC HEALTH, INC.

发明人： Joffre B. BAKER ,  Dominick SINICROPI ,  Robert J. PELHAM ,  Michael R. CRAGER ,  Francois COLLIN ,  James C. STEPHANS ,  Mei-Lan LIU ,  John D. MORLAN ,  Kunbin QU

IPC分类号： C12Q1/6886 ,  G01N33/574 ,  C12Q1/686 ,  G16B20/00

摘要： The present invention relates to biomarkers associated with breast cancer prognosis. These biomarkers include coding transcripts and their expression products, as well as non-coding transcripts, and are useful for predicting the likelihood of breast cancer recurrence in a breast cancer patient. The present invention also relates to a novel method of identifying intergenic sequences that correlate with a clinical outcome.

公开(公告)号：US20160048632A1

公开(公告)日：2016-02-18

申请号：US14779428

申请日：2014-05-29

申请人： GENOMIC HEALTH, INC.

发明人： Steven SHAK ,  George Andrew WATSON ,  Michael R. CRAGER ,  Tara MADDALA ,  Margarita LOPATIN ,  Audrey GODDARD ,  Dejan KNEZEVIC ,  Christer SVEDMAN

IPC分类号： G06F19/18 ,  G06F19/00

CPC分类号： G06F19/18 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G06F19/00 ,  G06F19/70 ,  G16H50/30

摘要： The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence.

摘要翻译： 本发明提供基于算法的分子测定法，其涉及测量从肾癌患者获得的生物样品的基因的表达水平。 本发明还提供了基于从肾癌患者获得的生物样品的基因的表达水平的测量来获得患有肾癌的患者的定量评分的方法。 这些基因可以分为功能基因子集，用于计算定量评分，并且可以根据其对癌症复发的贡献来加权基因亚群。

公开(公告)号：US20190256923A1

公开(公告)日：2019-08-22

申请号：US16250179

申请日：2019-01-17

申请人： GENOMIC HEALTH, INC.

发明人： Joffre B. BAKER ,  Dominick SINICROPI ,  Robert J. PELHAM ,  Michael R. CRAGER ,  Francois COLLIN ,  James C. STEPHANS ,  Mei-Lan LIU ,  John D. MORLAN ,  Kunbin QU

IPC分类号： C12Q1/6886 ,  G16B20/00 ,  C12Q1/686 ,  G01N33/574

摘要： The present invention relates to biomarkers associated with breast cancer prognosis. These biomarkers include coding transcripts and their expression products, as well as non-coding transcripts, and are useful for predicting the likelihood of breast cancer recurrence in a breast cancer patient. The present invention also relates to a novel method of identifying intergenic sequences that correlate with a clinical outcome.

公开(公告)号：US20190095575A1

公开(公告)日：2019-03-28

申请号：US16199707

申请日：2018-11-26

申请人： Genomic Health, Inc.

发明人： Steven SHAK ,  George Andrew WATSON ,  Michael R. CRAGER ,  Tara MADDALA ,  Margarita LOPATIN ,  Audrey GODDARD ,  Dejan KNEZEVIC ,  Christer SVEDMAN

IPC分类号： G06F19/18 ,  G16H50/30 ,  G06F19/00 ,  C12Q1/6886

摘要： The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence.

公开(公告)号：US20160222463A1

公开(公告)日：2016-08-04

申请号：US15011206

申请日：2016-01-29

申请人： GENOMIC HEALTH, INC.

发明人： Joffre B. BAKER ,  Dominick S. SINICROPI ,  Robert J. PELHAM ,  Michael R. CRAGER ,  Francois COLLIN ,  James C. STEPHANS ,  Mei-Lan LIU ,  John D. MORLAN ,  Kunbin QU

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/686 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/57415 ,  G01N2800/54 ,  G01N2800/56 ,  G01N2800/60 ,  G16B20/00

摘要： The present invention relates to biomarkers associated with breast cancer prognosis. These biomarkers include coding transcripts and their expression products, as well as non-coding transcripts, and are useful for predicting the likelihood of breast cancer recurrence in a breast cancer patient, The present invention also relates to a novel method of identifying intergenic sequences that correlate with a clinical outcome.

摘要翻译： 本发明涉及与乳腺癌预后相关的生物标志物。 这些生物标志物包括编码转录物及其表达产物，以及非编码转录物，并且可用于预测乳腺癌患者乳腺癌复发的可能性。本发明还涉及一种鉴定与之相关的基因间序列的新方法 具有临床结果。