公开(公告)号：US11054113B2

公开(公告)日：2021-07-06

申请号：US16271048

申请日：2019-02-08

申请人： Gentex Corporation ,  Mayo Foundation for Medical Education and Research

发明人： Jason D. Hallack ,  Joshua D. Lintz ,  David M. Falb ,  Kurtis L. Geerlings ,  William L. Tonar ,  Bradley R. Hamlin ,  Jeremy A. Schut ,  Mark A. VanVuuren ,  Steven J. Veenman ,  Jordan D. Miller ,  Heidi Nelson

IPC分类号： F21V14/02 ,  F21V23/04 ,  F21S8/04 ,  F21V23/00 ,  F21W131/205 ,  F21W131/208 ,  A61B90/30 ,  F21W131/20 ,  F21W131/202 ,  F21V21/30

摘要： A light assembly is configured to selectively illuminate an operating region in a surgical suite. The assembly comprises a plurality of lighting modules comprising a plurality of light sources configured to emit light. The assembly further comprises at least one imager configured to capture image data disposed in at least one of the lighting modules. An articulating head assembly is configured to support each of the lighting modules. The articulating head assembly comprises a plurality of actuators configured to rotate each of the lighting modules about a first axis and a second axis. The assembly further comprises a controller. The controller is configured to scan the image data for at least one region of interest comprising at least one of a shaded region and a contaminated region.

公开(公告)号：US10238669B2

公开(公告)日：2019-03-26

申请号：US15702461

申请日：2017-09-12

申请人： Mayo Foundation for Medical Education and Research

发明人： Jordan D. Miller ,  Bin Zhang

IPC分类号： A61K45/06 ,  A61K31/197 ,  A61K31/416 ,  A61K31/506 ,  A61K31/519 ,  A61K31/635 ,  A61K31/4985 ,  A61K31/5377

摘要： This document provides methods and materials involved in treating cardiovascular conditions such as calcific aortic valve stenosis. For example, methods and materials for using sGC agonists or a combination of sGC agonists and PDE5A inhibitors to reduce calcification of heart valves and/or vessels or to slow progression of aortic sclerosis to calcific aortic valve stenosis are provided.

公开(公告)号：US20180071320A1

公开(公告)日：2018-03-15

申请号：US15702461

申请日：2017-09-12

申请人： Mayo Foundation for Medical Education and Research

发明人： Jordan D. Miller ,  Bin Zhang

IPC分类号： A61K31/635 ,  A61K31/197 ,  A61K31/416 ,  A61K31/4985 ,  A61K31/506 ,  A61K45/06 ,  A61K31/519 ,  A61K31/5377

CPC分类号： A61K31/635 ,  A61K31/197 ,  A61K31/416 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  A61K2300/00

摘要： This document provides methods and materials involved in treating cardiovascular conditions such as calcific aortic valve stenosis. For example, methods and materials for using sGC agonists or a combination of sGC agonists and PDE5A inhibitors to reduce calcification of heart valves and/or vessels or to slow progression of aortic sclerosis to calcific aortic valve stenosis are provided.

公开(公告)号：US20220218771A1

公开(公告)日：2022-07-14

申请号：US17610181

申请日：2020-05-11

申请人： Mayo Foundation for Medical Education and Research ,  Zhejiang ShouXianGu Pharmaceutical Co., Ltd.

发明人： Jordan D. Miller ,  Bin Zhang ,  Xinyan Liu

IPC分类号： A61K36/074 ,  A61P9/00

摘要： This document provides methods and materials involved in identifying and/or treating mammals having a cardiovascular disease. For example, this document provides methods and materials for administering a composition comprising a Ganoderma lucidum extract to a mammal identified as having or as being at risk of having cardiovascular disease. This document also provides methods and materials for slowing the progression of an age-related, acquired, or congenital cardiac dysfunction also are provided.

公开(公告)号：US20200230158A1

公开(公告)日：2020-07-23

申请号：US16717302

申请日：2019-12-17

申请人： Mayo Foundation for Medical Education and Research

发明人： Jordan D. Miller ,  Bin Zhang

IPC分类号： A61K31/635 ,  A61K31/5377 ,  A61K31/519 ,  A61K45/06 ,  A61K31/506 ,  A61K31/4985 ,  A61K31/416 ,  A61K31/197

摘要： This document provides methods and materials involved in treating cardiovascular conditions such as calcific aortic valve stenosis. For example, methods and materials for using sGC agonists or a combination of sGC agonists and PDE5A inhibitors to reduce calcification of heart valves and/or vessels or to slow progression of aortic sclerosis to calcific aortic valve stenosis are provided.

公开(公告)号：US20170216286A1

公开(公告)日：2017-08-03

申请号：US15113723

申请日：2015-01-28

申请人： Mayo Foundation for Medical Education and Research

发明人： James L. Kirkland ,  Tamar Tchkonia ,  Yi Zhu ,  Allyson K. Palmer ,  Nathan K. LeBrasseur ,  Jordan D. Miller

IPC分类号： A61K31/506 ,  A61K31/352

CPC分类号： A61K31/506 ,  A61K31/352 ,  A61K31/353 ,  A61K31/665 ,  A61K31/7048 ,  A61K45/06 ,  A61K2300/00

摘要： Provided herein are methods and uses for treatment or prophylaxis of a senescent cell associated disease or disorder by administering a senolytic combination comprising dasatinib and quercetin or an analog thereof to a subject in need thereof. In certain embodiments, the senescent cell associated disease or disorder is a cardiovascular disease or disorder, inflammatory disease or disorder, a pulmonary disease or disorder, a neurological disease or disorder, or a metabolic disease or disorder.

公开(公告)号：US20220062307A1

公开(公告)日：2022-03-03

申请号：US17521453

申请日：2021-11-08

申请人： Mayo Foundation for Medical Education and Research

发明人： Jordan D. Miller ,  Bin Zhang

IPC分类号： A61K31/635 ,  A61K31/197 ,  A61K31/416 ,  A61K31/4985 ,  A61K31/506 ,  A61K45/06 ,  A61K31/519 ,  A61K31/5377

摘要： This document provides methods and materials involved in treating cardiovascular conditions such as calcific aortic valve stenosis. For example, methods and materials for using sGC agonists or a combination of sGC agonists and PDE5A inhibitors to reduce calcification of heart valves and/or vessels or to slow progression of aortic sclerosis to calcific aortic valve stenosis are provided.

公开(公告)号：US10028973B2

公开(公告)日：2018-07-24

申请号：US14861428

申请日：2015-09-22

申请人： Mayo Foundation for Medical Education and Research

发明人： Jordan D. Miller

IPC分类号： A61K31/706

摘要： Materials and methods for using DNA methyltransferase inhibitors to slow progression of aortic valve calcification and stenosis are provided.

公开(公告)号：US09789126B2

公开(公告)日：2017-10-17

申请号：US14652903

申请日：2013-12-20

申请人： Mayo Foundation for Medical Education and Research

发明人： Jordan D. Miller ,  Bin Zhang

IPC分类号： A61K31/635 ,  A61K45/06 ,  A61K31/197 ,  A61K31/416 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377

CPC分类号： A61K31/635 ,  A61K31/197 ,  A61K31/416 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  A61K2300/00

摘要： This document provides methods and materials involved in treating cardiovascular conditions such as calcific aortic valve stenosis. For example, methods and materials for using sGC agonists or a combination of sGC agonists and PDE5A inhibitors to reduce calcification of heart valves and/or vessels or to slow progression of aortic sclerosis to calcific aortic valve stenosis are provided.

公开(公告)号：US20160082025A1

公开(公告)日：2016-03-24

申请号：US14861428

申请日：2015-09-22

申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

发明人： Jordan D. Miller

IPC分类号： A61K31/706

CPC分类号： A61K31/706

摘要： Materials and methods for using DNA methyltransferase inhibitors to slow progression of aortic valve calcification and stenosis are provided.

摘要翻译： 提供了使用DNA甲基转移酶抑制剂缓慢主动脉瓣钙化和狭窄进展的材料和方法。