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公开(公告)号：US12083095B2
公开(公告)日：2024-09-10
申请号：US17657826
申请日：2022-04-04
发明人： Jin Seok Hur
IPC分类号： A61K31/352 , A61K36/185 , B01D15/18 , B01D15/32 , C07K1/22 , G01N30/02 , G01N30/06
CPC分类号： A61K31/352 , A61K36/185 , B01D15/1871 , B01D15/322 , C07K1/22 , G01N30/02 , B01D15/1821 , G01N2030/065
摘要： The invention relates to a method for the chromatographic purification of at least one cannabinoid compound, wherein the method comprises a main purification stage comprising the steps of: injecting an initial mixture comprising the at least one cannabinoid compound and one or more additional compounds onto a main stationary phase comprising silica particles, the silica particles comprising amino and/or diol groups; performing an elution with an elution solution, and collecting one or more elution fractions; and optionally, washing the main stationary phase with a washing solution and collecting one or more washing fractions; at least one of the elution fractions or washing fractions containing the at least one cannabinoid compound purified from the one or more additional compounds.
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公开(公告)号：US12024751B2
公开(公告)日：2024-07-02
申请号：US16464356
申请日：2017-11-24
申请人： SAMYANG CORPORATION
发明人： Ji Won Park , Sung Won Park , Hye Jung Kim , Chong Jin Park , Kang Pyo Lee
CPC分类号： C13K13/007 , B01D15/185 , B01D15/1871 , B01D15/242 , B01D15/362 , C13K11/00
摘要： The present invention relates to a method for effectively utilizing fructose raffinate obtained in the process for separating psicose conversion product with a high purity chromatography in the process for preparing psicose, and more specifically, it is utilized for preparation of fructose-containing raw material solution for preparing psicose by supplying the fructose raffinate obtained in the separation step of psicose preparation into the psicose conversion reaction.
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公开(公告)号：US20240116970A1
公开(公告)日：2024-04-11
申请号：US18470691
申请日：2023-09-20
申请人： PURECIRCLE SDN BHD
发明人： Avetik MARKOSYAN
IPC分类号： C07H15/256 , A21D2/18 , A23C9/13 , A23G1/40 , A23G3/42 , A23G9/34 , A23L2/02 , A23L2/60 , A23L27/30 , A23L27/50 , A61K8/60 , A61K31/7034 , A61K31/704 , A61K36/28 , A61Q11/00 , B01D15/18 , B01D15/42 , C07H1/06 , C07H1/08
CPC分类号： C07H15/256 , A21D2/181 , A23C9/1307 , A23G1/40 , A23G3/42 , A23G9/34 , A23L2/02 , A23L2/60 , A23L27/36 , A23L27/50 , A61K8/602 , A61K31/7034 , A61K31/704 , A61K36/28 , A61Q11/00 , B01D15/1871 , B01D15/1885 , B01D15/426 , C07H1/06 , C07H1/08 , A23V2002/00 , A61K2236/00
摘要： Methods of preparing highly purified steviol glycosides, particularly Rebaudioside D, are described. The methods include purification from the extraction stage of the Stevia rebaudiana Bertoni plant, purification of steviol glycoside mixtures, Rebaudioside D and Rebaudioside A from a commercial Stevia extract, and purification of Rebaudioside D from remaining solutions obtained after isolation and purification of Rebaudioside A and a high purity mixture of steviol glycosides. The methods are useful for producing high purity Rebaudioside D, Rebaudioside A, and steviol glycoside mixtures. The high purity steviol glycosides are useful as non-caloric sweeteners in edible and chewable compositions such as any beverages, confectioneries, bakery products, cookies, and chewing gums.
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公开(公告)号：US20230365946A1
公开(公告)日：2023-11-16
申请号：US18186731
申请日：2023-03-20
申请人： Genzyme Corporation
发明人： Thomas M. Wasylenko , Kevin Brower , Xiaoying Jin
CPC分类号： C12N9/16 , C12Y301/04012 , A61P3/00 , B01D15/362 , B01D15/3828 , B01D15/1871 , B01D15/203 , A61K38/00
摘要： Disclosed here are compositions comprising recombinant acid sphingomyelinase (rASM) having desired purity, specific activity, and/or rASM isoforms. Also provided are methods for making and purifying such compositions, comprising chromatography steps. Further provided are methods of modulating rASM specific activity in a composition, and methods of modulating rASM isoforms in a composition. The methods disclosed here can be particularly useful for manufacturing pharmaceutical compositions comprising rASM for treating acid sphingomyelinase deficiency (ASMD).
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公开(公告)号：US11801505B2
公开(公告)日：2023-10-31
申请号：US17570891
申请日：2022-01-07
发明人： Hiroki Taniguchi
IPC分类号： B01D15/18 , B01D15/36 , B01D15/38 , B01J39/05 , B01J39/20 , B01J39/26 , C07K1/18 , C07K1/22 , C07K16/00 , C08F255/02 , C08J5/22 , B01J39/07 , B01J47/12 , G01N30/02 , G01N30/88 , B01J47/127
CPC分类号： B01J39/26 , B01D15/1871 , B01D15/36 , B01D15/362 , B01D15/363 , B01D15/3809 , B01J39/05 , B01J39/07 , B01J39/20 , B01J47/12 , B01J47/127 , C07K1/18 , C07K1/22 , C07K16/00 , C08F255/02 , C08F255/023 , C08J5/22 , C08J5/2287 , G01N30/02 , G01N30/88
摘要： A cation exchange chromatographic matrix comprising a base material, and a copolymer with one monomer unit having at least a sulfonic acid group, the copolymer being immobilized on the base material, wherein: the copolymer forms substantially no cross-linked structure, and the copolymer comprises neither acrylamide nor an acrylamide derivative as a monomer unit, or comprises acrylamide or an acrylamide derivative as a monomer unit in a range which has no substantial influence; the ratio of the mass of the copolymer to the mass of the base material is 5% or more and 200% or less; and the density of the sulfonic acid group is higher than 30 mmol/L and 200 mmol/L or lower.
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公开(公告)号：US11798700B2
公开(公告)日：2023-10-24
申请号：US17040652
申请日：2019-03-26
CPC分类号： G21G1/001 , B01D15/1871 , B01D15/362 , B01D15/363 , C01B15/0475 , C01F17/13 , G21G1/10 , G21G2001/0089 , G21G2001/0094
摘要： A method of separating actinium and/or radium from proton-irradiated thorium metal. The thorium metal is irradiated to produce isotopes including thorium, actinium and/or radium. The resultant product is dissolved in solution and a selective precipitant is used to precipitate a bulk portion of the thorium. The precipitated thorium can be recovered. Chromatography is carried out on the remaining solution to remove residual thorium and to separate the actinium from the radium.
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公开(公告)号：US20230226463A1
公开(公告)日：2023-07-20
申请号：US18188313
申请日：2023-03-22
IPC分类号： B01D15/18
CPC分类号： B01D15/1828 , B01D15/1871 , B01D15/1842 , B01D15/1807 , B01D15/1885 , B01D2215/023
摘要： The present invention relates to a method for separating one or more components from a liquid feed mixture in an EBA-SMB operating mode without the need of pumps at the outlets of the EBA columns. The present invention also relates to a simulated moving bed separation device with expanded bed adsorption columns which can be used in the method according to the invention.
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公开(公告)号：US10011786B1
公开(公告)日：2018-07-03
申请号：US15445681
申请日：2017-02-28
申请人： UOP LLC
CPC分类号： C10G67/06 , B01D15/1814 , B01D15/1871 , B01D15/1885
摘要： One exemplary embodiment can be a process for treating a hydrocracking fraction. The process can include obtaining a bottom stream from a fractionation column, stripping HPNAs from the bottoms stream and adsorbing HPNAs from the stripped stream to provide an adsorbed stream that can meet a desired HPNA concentration specification. The adsorption step can be adjusted to achieve an adjusted HPNA concentration.
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公开(公告)号：US20170190728A1
公开(公告)日：2017-07-06
申请号：US15425295
申请日：2017-02-06
申请人： PureCircle Sdn Bhd
发明人： Avetik MARKOSYAN
IPC分类号： C07H15/256 , A21D2/18 , A23C9/13 , A23G1/40 , B01D15/42 , A23G9/34 , A23L2/02 , A23L2/60 , A23L27/50 , B01D15/18 , C07H1/08 , A23G3/42
CPC分类号： C07H15/256 , A21D2/181 , A23C9/1307 , A23G1/40 , A23G3/42 , A23G9/34 , A23L2/02 , A23L2/60 , A23L27/36 , A23L27/50 , A23V2002/00 , A61K8/602 , A61K31/7034 , A61K31/704 , A61K36/28 , A61K2236/00 , A61Q11/00 , B01D15/1871 , B01D15/1885 , B01D15/426 , C07H1/06 , C07H1/08
摘要： Methods of preparing highly purified steviol glycosides, particularly Rebaudioside D, are described. The methods include purification from the extraction stage of the Stevia rebaudiana Bertoni plant, purification of steviol glycoside mixtures, Rebaudioside D and Rebaudioside A from a commercial Stevia extract, and purification of Rebaudioside D from remaining solutions obtained after isolation and purification of Rebaudioside A and a high purity mixture of steviol glycosides. The methods are useful for producing high purity Rebaudioside D, Rebaudioside A, and steviol glycoside mixtures. The high purity steviol glycosides are useful as non-caloric sweeteners in edible and chewable compositions such as any beverages, confectioneries, bakery products, cookies, and chewing gums.
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公开(公告)号：US20170166993A1
公开(公告)日：2017-06-15
申请号：US15327041
申请日：2015-07-17
发明人： Nien-Hwa Linda Wang , Lei Ling
CPC分类号： C22B3/0098 , B01D15/166 , B01D15/1871 , B01D15/362 , B01D15/3828 , B01D15/42 , C22B3/06 , C22B3/24 , C22B59/00 , Y02P10/234
摘要： Presented herein is a ligand-assisted elution chromatography process for the separation of metal ions using a sorbent. An inorganic sorbent, titania, for example, has three types of adsorption sites: Bronsted acid (BA), Bronsted base (BB), and Lewis acid (LA). At a high pH, the BA sites can interact with the metal ions as a cation exchanger. If a ligand with COO groups is preloaded onto the sorbent, the COO— groups of the ligand can adsorb onto the LA sites. The adsorbed. ligands become strong adsorption sites for the metal ions. If the Langmuir a value for metal ion adsorption is similar to that of metal ion complexation with the ligand in the mobile phase, the different metal ions can be eluted separately with an overall selectivity which is equal to the ratio of the ligand selectivity to the sorbent selectivity.
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