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    Methods for detecting and correcting inaccurate results in inductively coupled plasma-atomic emission spectrometry
    1.
    发明授权
    Methods for detecting and correcting inaccurate results in inductively coupled plasma-atomic emission spectrometry 有权
    电感耦合等离子体原子发射光谱法检测和校正不准确结果的方法

    公开(公告)号：US07768639B1

    公开(公告)日：2010-08-03

    申请号：US12212915

    申请日：2008-09-18

    申请人： George C. Y. Chan ,  Gary M. Hieftje

    发明人： George C. Y. Chan ,  Gary M. Hieftje

    IPC分类号： G01N21/73

    CPC分类号： G01N21/73 ,  G01N21/274

    摘要： A method for detecting and correcting inaccurate results in inductively coupled plasma-atomic emission spectrometry (ICP-AES). ICP-AES analysis is performed across a plurality of selected locations in the plasma on an unknown sample, collecting the light intensity at one or more selected wavelengths of one or more sought-for analytes, creating a first dataset. The first dataset is then calibrated with a calibration dataset creating a calibrated first dataset curve. If the calibrated first dataset curve has a variability along the location within the plasma for a selected wavelength, errors are present. Plasma-related errors are then corrected by diluting the unknown sample and performing the same ICP-AES analysis on the diluted unknown sample creating a calibrated second dataset curve (accounting for the dilution) for the one or more sought-for analytes. The cross-over point of the calibrated dataset curves yields the corrected value (free from plasma related errors) for each sought-for analyte.

    摘要翻译： 一种在电感耦合等离子体原子发射光谱法（ICP-AES）中检测和校正不准确结果的方法。 在未知样品上的等离子体中的多个选定位置上进行ICP-AES分析，收集一种或多种所寻找分析物的一个或多个所选波长的光强度，从而产生第一数据集。 然后用校准数据集校准第一个数据集，创建校准的第一个数据集曲线。 如果校准的第一数据集曲线沿着所选波长的等离子体内的位置具有可变性，则存在错误。 然后通过稀释未知样品并对稀释的未知样品进行相同的ICP-AES分析来校正等离子体相关误差，产生针对一种或多种所寻找分析物的校准的第二数据集曲线（占稀释度）。 校准数据集曲线的交叉点产生每个寻找分析物的校正值（无等离子体相关误差）。

    Device for the accurate dispensing of small volumes of liquid samples
    2.
    发明授权
    Device for the accurate dispensing of small volumes of liquid samples 失效
    用于准确分配少量液体样品的装置

    公开(公告)号：US4492322A

    公开(公告)日：1985-01-08

    申请号：US373647

    申请日：1982-04-30

    申请人： Gary M. Hieftje ,  John Shabushnig

    发明人： Gary M. Hieftje ,  John Shabushnig

    IPC分类号： B01L3/02 ,  B67D5/00

    CPC分类号： B01L3/0268

    摘要： A device for accurately dispensing small volumes of liquids in the form of uniform droplets. The dispensing device communicates with a source of compressed air which, during start-up transience of the dispensing device, directs a jet of compressed air at the trajectory of dispensed droplets, thereby deflecting the droplets out of their normal trajectory and away from the collecting surface or container and allowing accurate dispensing.

    摘要翻译： 用于精确分配均匀液滴形式的小体积液体的装置。 分配装置与压缩空气源连通，在分配装置的启动瞬态期间，在分配的液滴的轨迹处引导压缩空气流，从而使液滴偏离其正常轨迹并远离收集表面 或容器，并允许精确的分配。

    RESOLUTION AND MASS RANGE PERFORMANCE IN DISTANCE-OF-FLIGHT MASS SPECTROMETRY WITH A MULTICHANNEL FOCAL-PLANE CAMERA DETECTOR
    5.
    发明申请
    RESOLUTION AND MASS RANGE PERFORMANCE IN DISTANCE-OF-FLIGHT MASS SPECTROMETRY WITH A MULTICHANNEL FOCAL-PLANE CAMERA DETECTOR 审中-公开
    使用多通道光学平面相机检测器的距离飞行质谱分辨率和质谱范围性能

    公开(公告)号：US20140138538A1

    公开(公告)日：2014-05-22

    申请号：US14110998

    申请日：2012-04-16

    申请人： Gary M. Hieftje ,  Christie George Enke ,  Alexander W. Graham ,  Steven J. Ray ,  Elise Dennis ,  Charles J. Barinaga ,  David W. Koppenaal

    发明人： Gary M. Hieftje ,  Christie George Enke ,  Alexander W. Graham ,  Steven J. Ray ,  Elise Dennis ,  Charles J. Barinaga ,  David W. Koppenaal

    IPC分类号： H01J49/34

    CPC分类号： H01J49/34 ,  H01J49/40

    摘要： A distance-of-flight mass spectrometer (DOFMS) includes an ion source, a field-free region, an extraction region in which ions are accelerated, and a spatially-selective detector for spatially selectively detecting ions extracted by the extraction region. A method for operating a distance-of-flight mass spectrometer DOFMS comprises controlling a detection time in such a way as to permit ions with progressively greater mass-to-charge (m/z) ratios to enter the extraction region of the DOFMS at positions which will permit the ions with progressively greater m/z ratios to enter the detector of the DOFMS, generating a component mass spectrum at each selected value of detection time, and then assembling a composite mass spectrum by shifting the distance-of-flight axis of each component mass spectrum by a distance corresponding to the change in detection time.

    摘要翻译： 飞行时间质谱仪（DOFMS）包括离子源，无场区域，其中离子被加速的提取区域和用于空间选择性地检测由提取区域提取的离子的空间选择性检测器。 用于操作飞行时间质谱仪DOFMS的方法包括以这样的方式控制检测时间，使得允许具有逐渐更大的质荷比（m / z）比的离子在位置处进入DOFMS的提取区域 这将允许具有逐渐更大的m / z比的离子进入DOFMS的检测器，在检测时间的每个选定值处产生组分质谱，然后通过将飞行时间轴的位移 每个组分质谱与检测时间的变化相对应。

    Simultaneous acquisition of chemical information
    9.
    发明授权
    Simultaneous acquisition of chemical information 有权
    同时获取化学信息

    公开(公告)号：US07294830B2

    公开(公告)日：2007-11-13

    申请号：US10500685

    申请日：2003-01-02

    申请人： Gary M. Hieftje ,  Steven J. Ray

    发明人： Gary M. Hieftje ,  Steven J. Ray

    IPC分类号： B01D59/44

    CPC分类号： H01J49/107

    摘要： A method and apparatus for operating a mass spectrometer include providing at least two different ion sources, and coupling ion streams simultaneously from the at least two different ion sources to the spectrometer. Another method of operating a spectrometer includes a first coupling an ion stream from a first one of the ion sources into the spectrometer, next coupling an ion stream from a second one of the ion sources into the spectrometer, next coupling an ion stream from the second one of the ion sources into the spectrometer, and next coupling an ion stream from the first one of the ion sources into the spectrometer.

    摘要翻译： 用于操作质谱仪的方法和装置包括提供至少两种不同的离子源，并且将离子流同时从至少两种不同的离子源耦合到光谱仪。 操作光谱仪的另一种方法包括将离子流中的第一离子源的离子流首先耦合到光谱仪中，然后将来自第二离子源的离子流耦合到光谱仪中，然后将离子流从第二离子流 离子源中的一个进入光谱仪，然后将来自第一个离子源的离子流耦合到光谱仪中。

    Time-of-flight mass spectrometer
    10.
    发明授权
    Time-of-flight mass spectrometer 失效
    飞行时间质谱仪

    公开(公告)号：US5614711A

    公开(公告)日：1997-03-25

    申请号：US434931

    申请日：1995-05-04

    申请人： Gangqiang Li ,  Gary M. Hieftje

    发明人： Gangqiang Li ,  Gary M. Hieftje

    IPC分类号： B01D59/44 ,  H01J49/40 ,  H01J49/00

    CPC分类号： H01J49/40 ,  B01D59/44

    摘要： A novel, time-of-flight mass spectrometer for the qualitative and quantitative analysis of elemental, molecular, and isotopic chemical samples is provided which offers increased sensitivity, speed of analysis, resolving power, and signal-to-noise ratios than prior mass spectrometers by properly sampling and collimating an ion beam from a continuous ion source, decelerating said ion, forming ion packets from the continuous ion beam, storing said ion packets, extracting and accelerating the ion packets along a stable flight path, transversely compressing said packets, focusing ions of similar mass, and detecting the focused ion masses. The mass spectrometer includes an ion optics assembly and an analyzer disposed along a common axis coincident with a continuous beam of sampled ions. The relationship between the ion extractor and accelerator are such that ions of isomass are focused at at least one point in space in the analyzer along a narrow flight path so as to be either removed from the flight path or allowed to proceed and be detected at substantially the same time. The separate modulation and extraction steps, when coupled with the space-focusing and selected deflection of certain ionic species, results in higher sensitivity, greater analysis speed, higher resolving power, and improved signal-to-noise ratio than achieved in prior orthogonal or on-axis time-of-flight mass spectrometers. A novel method achieved by the apparatus is also disclosed.

    摘要翻译： 提供了一种用于元素，分子和同位素化学样品的定性和定量分析的新型飞行时间质谱仪，其提供了比现有的质谱仪更高的灵敏度，分析速度，分辨率和信噪比 通过适当地对来自连续离子源的离子束进行采样和准直，使所述离子减速，从连续离子束形成离子包，存储所述离子包，沿着稳定的飞行路径提取和加速离子包，横向压缩所述包，聚焦 离子质量相似，并检测聚焦离子质量。 质谱仪包括离子光学组件和沿着与连续的取样离子束重合的共同轴设置的分析仪。 离子提取器和加速器之间的关系使得等离子体的离子沿着窄的飞行路径聚焦在分析仪中的空间中的至少一个点处，以便从飞行路径移除或允许进行并基本上被检测 同一时间。 单独的调制和提取步骤当与某些离子物质的空间聚焦和选择的偏转相结合时，导致比在先前的正交或在之前实现的更高的灵敏度，更高的分析速度，更高的分辨能力和改善的信噪比 -axis飞行时间质谱仪。 还公开了一种由该装置实现的新颖方法。