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    Ion Focusing and Detection in a Miniature Linear Ion Trap for Mass Spectrometry
    5.
    发明申请
    Ion Focusing and Detection in a Miniature Linear Ion Trap for Mass Spectrometry 有权
    用于质谱的微型线性离子阱中的离子聚焦和检测

    公开(公告)号：US20100019143A1

    公开(公告)日：2010-01-28

    申请号：US11753455

    申请日：2007-05-24

    申请人： Gareth S Dobson ,  Christie G. Enke

    发明人： Gareth S Dobson ,  Christie G. Enke

    IPC分类号： H01J49/26 ,  B01D59/44

    CPC分类号： H01J49/4225 ,  H01J49/0013

    摘要： A miniature linear ion trap (MLIT) with a length of less than 30 mm is provided for ion focusing in the axial plane. The MLIT has multipoles for applying an AC voltage to ions and tubular entrance and exit lenses for applying a DC voltage to the ions. In another aspect, MLIT includes electrodes within the tubular entrance and exit lenses for detection of image current. A method is also provided for applying voltage to the entrance and exit lenses for ion focusing.

    摘要翻译： 提供长度小于30毫米的微型线性离子阱（MLIT）用于轴向平面中的离子聚焦。 MLIT具有用于向离子施加AC电压的多极和用于向离子施加DC电压的管状入口和出口透镜。 在另一方面，MLIT包括用于检测图像电流的管状入口和出射透镜内的电极。 还提供了一种用于向入射和离开透镜施加电压用于离子聚焦的方法。

    Ion mirror
    6.
    发明授权
    Ion mirror 失效
    离子镜

    公开(公告)号：US06518569B1

    公开(公告)日：2003-02-11

    申请号：US09591536

    申请日：2000-06-09

    申请人： Jun Zhang ,  Benjamin D. Gardner ,  Christie G. Enke

    发明人： Jun Zhang ,  Benjamin D. Gardner ,  Christie G. Enke

    IPC分类号： H01J4900

    CPC分类号： H01J49/405

    摘要： Novel ion mirrors comprising, in a preferred embodiment, three cylinders, rectangles or truncated cones to improve the resolving power in the time-of-flight mass spectrometers over broad ion kinetic energy ranges. The achieved electric field is non-linear along the mirror axis and relatively homogeneous in the mirror off-axis directions. Combined with dimension optimization, in a preferred embodiment, the adjustment of only two parameters of element voltages can yield preferred electric field distribution to fit different ion optical systems.

    摘要翻译： 在一个优选实施例中，新型离子镜包括三个圆柱体，矩形或截锥体，以在宽离子动能范围内提高飞行时间质谱仪中的分辨能力。 实现的电场沿着镜像轴是非线性的，并且在反射镜离轴方向上相对均匀。 结合尺寸优化，在优选实施例中，仅调整元件电压的两个参数可以产生优选的电场分布以配合不同的离子光学系统。

    Combination of time resolution and mass dispersive techniques in mass spectrometry
    7.
    发明授权
    Combination of time resolution and mass dispersive techniques in mass spectrometry 失效
    时间分辨率和质谱分析技术在质谱中的组合

    公开(公告)号：US4472631A

    公开(公告)日：1984-09-18

    申请号：US385114

    申请日：1982-06-04

    申请人： Christie G. Enke ,  John F. Holland ,  John T. Stults

    发明人： Christie G. Enke ,  John F. Holland ,  John T. Stults

    IPC分类号： B01D59/44 ,  H01J49/02 ,  H01J49/32 ,  H01J49/40

    CPC分类号： H01J49/40 ,  B01D59/44 ,  H01J49/004 ,  H01J49/28

    摘要： Time of flight mass spectrometry techniques are simultaneously combined with path-bending spatial dispersion in magnetic- or electric-sector mass spectrometers to improve the mass resolution or, with an ion fragmentation region, to rapidly obtain multidimensional mass spectral data previously only obtainable by tandem mass spectrometry. The instrumentation generates data defining relationships between parent ions and daughter ions produced by fragmentation, metastable or induced, data to differentiate stable from metastable ions, and data to improve mass resolution. The subject time-resolved mass spectrometers can be combined with chromatography apparatus to obtain multidimensional MS/MS-type data during the relatively short duration of a single chromatographic peak.

    摘要翻译： 飞行时间质谱技术与磁电或电扇区质谱仪中的路径弯曲空间色散同时组合以改善质量分辨率，或者利用离子碎片区域快速获得以前只能通过串联质量获得的多维质谱数据 光谱测定。 仪器产生的数据定义了通过断裂，亚稳态或诱导产生的亲本离子和子离子之间的关系，数据以区分稳定离子和亚稳态离子，并提供数据以改善质量分辨率。 主题时间分辨质谱仪可以与色谱装置组合，以在单个色谱峰的相对短的持续时间内获得多维MS / MS型数据。

    Ion focusing and detection in a miniature linear ion trap for mass spectrometry
    8.
    发明授权
    Ion focusing and detection in a miniature linear ion trap for mass spectrometry 有权
    用于质谱的微型线性离子阱中的离子聚焦和检测

    公开(公告)号：US07960692B2

    公开(公告)日：2011-06-14

    申请号：US11753455

    申请日：2007-05-24

    申请人： Gareth S. Dobson ,  Christie G. Enke

    发明人： Gareth S. Dobson ,  Christie G. Enke

    IPC分类号： H01J49/26 ,  H01J49/40

    CPC分类号： H01J49/4225 ,  H01J49/0013

    摘要： A miniature linear ion trap (MLIT) with a length of less than 30 mm is provided for ion focusing in the axial plane. The MLIT has multipoles for applying an AC voltage to ions and tubular entrance and exit lenses for applying a DC voltage to the ions. In another aspect, MLIT includes electrodes within the tubular entrance and exit lenses for detection of image current. A method is also provided for applying voltage to the entrance and exit lenses for ion focusing.

    摘要翻译： 提供长度小于30毫米的微型线性离子阱（MLIT）用于轴向平面中的离子聚焦。 MLIT具有用于向离子施加AC电压的多极和用于向离子施加DC电压的管状入口和出口透镜。 在另一方面，MLIT包括用于检测图像电流的管状入口和出射透镜内的电极。 还提供了一种用于向入射和离开透镜施加电压用于离子聚焦的方法。

    Distance of flight spectrometer for MS and simultaneous scanless MS/MS
    9.
    发明授权
    Distance of flight spectrometer for MS and simultaneous scanless MS/MS 有权
    飞行谱仪与MS同步无扫描MS / MS的距离

    公开(公告)号：US07429728B2

    公开(公告)日：2008-09-30

    申请号：US11360872

    申请日：2006-02-23

    申请人： Christie G. Enke

    发明人： Christie G. Enke

    IPC分类号： H01J49/40

    CPC分类号： H01J49/40 ,  G01N27/622 ,  H01J49/0045

    摘要： A distance of flight (DOF) approach to mass spectroscopy in which the resolution among the various ion masses is accomplished in space rather than time. A separate detector is associated with each ion mass resolution element. The DOF mass spectrometer can serve as one element in a tandem arrangement which has the capability to produce a full two-dimensional precursor/product spectrum for each bunch of ions extracted from the source. A “distance-of-flight” (DOF) mass analyzer is used in combination with time-of-flight (TOF) mass analysis for precursor and product dispersion. All the precursor ions can undergo a mass changing reaction simultaneously, while still retaining the essential information about the particular precursor m/z value from which each product ion m/z value emanated. Through the use of a two-dimensional detector, all the products ions from all the precursors can be detected for each batch of ions analyzed.

    摘要翻译： 距离飞行（DOF）方法到质谱法，其中各种离子质量的分辨率在空间而不是时间内完成。 单独的检测器与每个离子质量分辨率元件相关联。 DOF质谱仪可以作为串联布置的一个元件，其能够为从源提取的每束离子产生完整的二维前体/产物光谱。 使用“飞行距离”（DOF）质谱仪与飞行时间（TOF）质量分析结合使用前体和产品分散。 所有前体离子可以同时进行质量变化反应，同时仍然保留关于每个产物离子m / z值发射的特定前体m / z值的基本信息。 通过使用二维检测器，可以对分析的每批离子检测来自所有前体的所有产物离子。

    Distance of flight spectrometer for MS and simultaneous scanless MS/MS
    10.
    发明授权
    Distance of flight spectrometer for MS and simultaneous scanless MS/MS 有权
    飞行谱仪与MS同步无扫描MS / MS的距离

    公开(公告)号：US07041968B2

    公开(公告)日：2006-05-09

    申请号：US10804968

    申请日：2004-03-18

    申请人： Christie G. Enke

    发明人： Christie G. Enke

    IPC分类号： H01J49/40

    CPC分类号： H01J49/40 ,  G01N27/622 ,  H01J49/0045

    摘要： A distance of flight (DOF) approach to mass spectrometry in which the resolution among the various ion masses is accomplished in space rather than time. A separate detector is associated with each ion mass resolution element. The DOF mass spectrometer can serve as one element in a tandem arrangement which has the capability to produce a full two-dimensional precursor/product spectrum for each bunch of ions extracted from the source. A “distance-of-flight” (DOF) mass analyzer is used in combination with time-of-flight (TOF) mass analysis for precursor and product dispersion. All the precursor ions can undergo a mass changing reaction simultaneously, while still retaining the essential information about the particular precursor m/z value from which each product ion m/z value emanated. Through the use of a two-dimensional detector, all the products ions from all the precursors can be detected for each batch of ions analyzed.

    摘要翻译： 距离飞行（DOF）方法进行质谱分析，其中各种离子质量分辨率在空间而不是时间上完成。 单独的检测器与每个离子质量分辨率元件相关联。 DOF质谱仪可以作为串联布置的一个元件，其能够为从源提取的每束离子产生完整的二维前体/产物光谱。 使用“飞行距离”（DOF）质谱仪与飞行时间（TOF）质量分析结合使用前体和产品分散。 所有前体离子可以同时进行质量变化反应，同时仍然保留关于每个产物离子m / z值发射的特定前体m / z值的基本信息。 通过使用二维检测器，可以对分析的每批离子检测来自所有前体的所有产物离子。