公开(公告)号：US20070003008A1

公开(公告)日：2007-01-04

申请号：US11444660

申请日：2006-05-31

申请人： Benjamin Warner ,  George Havrilla ,  Thomasin Miller ,  Cris Lewis ,  Cynthia Mahan ,  Cyndi Wells

发明人： Benjamin Warner ,  George Havrilla ,  Thomasin Miller ,  Cris Lewis ,  Cynthia Mahan ,  Cyndi Wells

IPC分类号： G01N23/223 ,  G01T1/36

CPC分类号： G01N23/223 ,  G01N2223/076

摘要： Method and apparatus for screening chemicals using micro x-ray fluorescence. A method for screening a mixture of potential pharmaceutical chemicals for binding to at least one target binder involves flow-separating a solution of chemicals and target binders into separated components, exposing them to an x-ray excitation beam, detecting x-ray fluorescence signals from the components, and determining from the signals whether or not a binding event between a chemical and target binder has occurred.

摘要翻译： 使用微X射线荧光筛选化学品的方法和设备。 用于筛选用于结合至少一种靶粘合剂的潜在药物化学品混合物的方法包括将化学品和靶粘合剂的溶液流分离成分离的组分，将其暴露于x射线激发光束，检测X射线荧光信号 并且根据信号确定是否发生了化学和目标粘合剂之间的结合事件。

公开(公告)号：US20050214847A1

公开(公告)日：2005-09-29

申请号：US11125036

申请日：2005-05-09

申请人： George Havrilla ,  Thomasin Miller ,  Benjamin Warner ,  Cris Lewis ,  Cynthia Mahan ,  Cyndi Wells

发明人： George Havrilla ,  Thomasin Miller ,  Benjamin Warner ,  Cris Lewis ,  Cynthia Mahan ,  Cyndi Wells

IPC分类号： G01N23/223 ,  C12Q1/68 ,  C12M1/34 ,  G01N33/53

CPC分类号： G01N23/223 ,  G01N2223/076

摘要： Flow method and apparatus for screening chemicals using micro x-ray fluorescence. The invention includes a method and apparatus for screening a mixture of potential pharmaceutical chemicals for binding to at least one target binder. According to the method, after preparing a solution of potential pharmaceutical chemicals with at least one target binder, the solution is flow-separated into at least two separated components. Each component is exposed to an x-ray excitation beam. Any component that emits a detectable x-ray fluorescence signal is isolated.

摘要翻译： 使用微X射线荧光筛选化学品的流动方法和装置。 本发明包括用于筛选与至少一种目标粘合剂结合的潜在药物化学品混合物的方法和装置。 根据该方法，在制备具有至少一种目标粘合剂的潜在药物化学品溶液之后，将溶液流分离成至少两个分离的组分。 每个组件暴露于x射线激发光束。 发射可检测的X射线荧光信号的任何成分被分离出来。

公开(公告)号：US20050011818A1

公开(公告)日：2005-01-20

申请号：US10621825

申请日：2003-07-16

申请人： Benjamin Warner ,  George Havrilla ,  Thomasin Miller ,  Cyndi Wells

发明人： Benjamin Warner ,  George Havrilla ,  Thomasin Miller ,  Cyndi Wells

IPC分类号： G01N23/223 ,  G01N33/53 ,  B01D35/14

CPC分类号： G01N23/223 ,  G01N33/5306 ,  G01N2223/076 ,  Y10T436/13

摘要： The method for screening binding between a target binder and potential pharmaceutical chemicals involves sending a solution (preferably an aqueous solution) of the target binder through a conduit to a size exclusion filter, the target binder being too large to pass through the size exclusion filter, and then sending a solution of one or more potential pharmaceutical chemicals (preferably an aqueous solution) through the same conduit to the size exclusion filter after target binder has collected on the filter. The potential pharmaceutical chemicals are small enough to pass through the filter. Afterwards, x-rays are sent from an x-ray source to the size exclusion filter, and if the potential pharmaceutical chemicals form a complex with the target binder, the complex produces an x-ray fluorescence signal having an intensity that indicates that a complex has formed.

摘要翻译： 用于筛选目标粘合剂和潜在的药物化学药物之间的结合的方法包括将目标粘合剂的溶液（优选水溶液）通过导管送到尺寸排阻过滤器，目标粘合剂太大而不能通过尺寸排阻过滤器， 然后在将目标粘合剂收集在过滤器上之后，将一种或多种潜在的药物化学品（优选水溶液）的溶液通过相同的导管送至尺寸排阻过滤器。 潜在的药物化学品足够小以通过过滤器。 之后，将x射线从x射线源发送到尺寸排阻滤光片，如果潜在的药物化学品与靶结合物形成复合物，则复合物产生具有指示复合物的强度的X射线荧光信号 已形成。

公开(公告)号：US20050095636A1

公开(公告)日：2005-05-05

申请号：US10986519

申请日：2004-11-10

申请人： Benjamin Warner ,  George Havrilla ,  Thomasin Miller ,  Cyndi Wells

发明人： Benjamin Warner ,  George Havrilla ,  Thomasin Miller ,  Cyndi Wells

IPC分类号： G01N23/223 ,  G01N33/53 ,  C12Q1/68 ,  G01N33/567

CPC分类号： G01N23/223 ,  G01N33/5306 ,  G01N2223/076 ,  Y10T436/13

摘要： The method for screening binding between a target binder and potential pharmaceutical chemicals involves sending a solution (preferably an aqueous solution) of the target binder through a conduit to a size exclusion filter, the target binder being too large to pass through the size exclusion filter, and then sending a solution of one or more potential pharmaceutical chemicals (preferably an aqueous solution) through the same conduit to the size exclusion filter after target binder has collected on the filter. The potential pharmaceutical chemicals are small enough to pass through the filter. Afterwards, x-rays are sent from an x-ray source to the size exclusion filter, and if the potential pharmaceutical chemicals form a complex with the target binder, the complex produces an x-ray fluorescence signal having an intensity that indicates that a complex has formed.