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    Method and apparatus for detecting chemical binding
    1.
    发明申请
    Method and apparatus for detecting chemical binding 有权

    公开(公告)号：US20050095636A1

    公开(公告)日：2005-05-05

    申请号：US10986519

    申请日：2004-11-10

    申请人： Benjamin Warner ,  George Havrilla ,  Thomasin Miller ,  Cyndi Wells

    发明人： Benjamin Warner ,  George Havrilla ,  Thomasin Miller ,  Cyndi Wells

    IPC分类号： G01N23/223 ,  G01N33/53 ,  C12Q1/68 ,  G01N33/567

    CPC分类号： G01N23/223 ,  G01N33/5306 ,  G01N2223/076 ,  Y10T436/13

    摘要： The method for screening binding between a target binder and potential pharmaceutical chemicals involves sending a solution (preferably an aqueous solution) of the target binder through a conduit to a size exclusion filter, the target binder being too large to pass through the size exclusion filter, and then sending a solution of one or more potential pharmaceutical chemicals (preferably an aqueous solution) through the same conduit to the size exclusion filter after target binder has collected on the filter. The potential pharmaceutical chemicals are small enough to pass through the filter. Afterwards, x-rays are sent from an x-ray source to the size exclusion filter, and if the potential pharmaceutical chemicals form a complex with the target binder, the complex produces an x-ray fluorescence signal having an intensity that indicates that a complex has formed.

    MODULAR CASE AND METHOD OF FORMING THE SAME
    2.
    发明申请
    MODULAR CASE AND METHOD OF FORMING THE SAME 有权
    模块化案例及其形成方法

    公开(公告)号：US20130340235A1

    公开(公告)日：2013-12-26

    申请号：US14010972

    申请日：2013-08-27

    申请人： JAMES HARDIGG ,  MARK GAYDOS ,  GEORGE HAVRILLA ,  ROBERT MILLIKEN

    发明人： JAMES HARDIGG ,  MARK GAYDOS ,  GEORGE HAVRILLA ,  ROBERT MILLIKEN

    IPC分类号： B65D21/02

    CPC分类号： B65D21/0209 ,  B65D11/10 ,  B65D11/16 ,  B65D11/22 ,  Y10T29/49789 ,  Y10T29/49794 ,  Y10T29/49798 ,  Y10T29/49826

    摘要： A modular case and method of forming the same, the case preferably formed from a plurality of panels, edge members and corner pieces having ribs. The panels, edge members and corner pieces are preferably connected to align the ribs, forming substantially continuous ribs capable of distributing forces over a large area of the modular case. The case is most preferably made of plastic, the connections preferably being hot-plate welds. Most preferably, the panels and edge members have a dual skin construction with internal ribs, proving for greater strength and allowing for superior structural properties including air-/water-tight integrity. Edge members are preferably formed with protuberances to allow for better base-to-lid and case-to-case engagement. Hardware attachments to the modular case can be advantageously made while distributing the force on attachment points and without compromising structural integrity.

    摘要翻译： 一种组合式壳体及其形成方法，该壳体优选地由多个面板，边缘构件和具有肋的角块形成。 面板，边缘构件和角件优选地连接成对准肋，形成能够在模块化壳体的大面积上分布力的基本上连续的肋。 这种情况最好由塑料制成，连接件最好是热板焊接。 最优选地，面板和边缘构件具有带有内部肋的双皮肤结构，证明具有更大的强度并允许优异的结构特性，包括空气/水密的完整性。 边缘构件优选地形成有突起，以允许更好的基底到盖和壳到壳的接合。 可以有利地在模块化壳体上安装硬件，同时在附着点上分配力并且不影响结构完整性。

    Modular case and method of forming the same
    3.
    发明申请
    Modular case and method of forming the same 失效
    模块化案例及其形成方法

    公开(公告)号：US20070245651A1

    公开(公告)日：2007-10-25

    申请号：US11399206

    申请日：2006-04-06

    申请人： James Hardigg ,  Mark Gaydos ,  George Havrilla ,  Robert Milliken

    发明人： James Hardigg ,  Mark Gaydos ,  George Havrilla ,  Robert Milliken

    IPC分类号： E04H1/00

    CPC分类号： B65D21/0209 ,  B65D11/10 ,  B65D11/16 ,  B65D11/22 ,  Y10T29/49789 ,  Y10T29/49794 ,  Y10T29/49798 ,  Y10T29/49826

    摘要： A modular case and method of forming the same, the case preferably formed from a plurality of panels, edge members and corner pieces having ribs. The panels, edge members and corner pieces are preferably connected to align the ribs, forming substantially continuous ribs capable of distributing forces over a large area of the modular case. The case is most preferably made of plastic, the connections preferably being hot-plate welds. Most preferably, the panels and edge members have a dual skin construction with internal ribs, proving for greater strength and allowing for superior structural properties including air-/water-tight integrity. Edge members are preferably formed with protuberances to allow for better base-to-lid and case-to-case engagement. Hardware attachments to the modular case can be advantageously made while distributing the force on attachment points and without compromising structural integrity.

    摘要翻译： 一种组合式壳体及其形成方法，该壳体优选地由多个面板，边缘构件和具有肋的角块形成。 面板，边缘构件和角件优选地连接成对准肋，形成能够在模块化壳体的大面积上分布力的基本上连续的肋。 这种情况最好由塑料制成，连接件最好是热板焊接。 最优选地，面板和边缘构件具有带有内部肋的双皮肤结构，证明具有更大的强度并允许优异的结构特性，包括空气/水密的完整性。 边缘构件优选地形成有突起，以允许更好的基底到盖和壳到壳的接合。 可以有利地在模块化壳体上安装硬件，同时在附着点上分配力并且不影响结构完整性。

    Modular case and method of forming the same
    5.
    发明授权
    Modular case and method of forming the same 失效
    模块化案例及其形成方法

    公开(公告)号：US08640911B2

    公开(公告)日：2014-02-04

    申请号：US11399206

    申请日：2006-04-06

    申请人： James Hardigg ,  Mark Gaydos ,  George Havrilla ,  Robert Milliken

    发明人： James Hardigg ,  Mark Gaydos ,  George Havrilla ,  Robert Milliken

    IPC分类号： B65D25/00

    CPC分类号： B65D21/0209 ,  B65D11/10 ,  B65D11/16 ,  B65D11/22 ,  Y10T29/49789 ,  Y10T29/49794 ,  Y10T29/49798 ,  Y10T29/49826

    摘要： A modular case and method of forming the same, the case preferably formed from a plurality of panels, edge members and corner pieces having ribs. The panels, edge members and corner pieces are preferably connected to align the ribs, forming substantially continuous ribs capable of distributing forces over a large area of the modular case. The case is most preferably made of plastic, the connections preferably being hot-plate welds. Most preferably, the panels and edge members have a dual skin construction with internal ribs, proving for greater strength and allowing for superior structural properties including air-/water-tight integrity. Edge members are preferably formed with protuberances to allow for better base-to-lid and case-to-case engagement. Hardware attachments to the modular case can be advantageously made while distributing the force on attachment points and without compromising structural integrity.

    摘要翻译： 一种组合式壳体及其形成方法，该壳体优选地由多个面板，边缘构件和具有肋的角块形成。 面板，边缘构件和角件优选地连接成对准肋，形成能够在模块化壳体的大面积上分布力的基本上连续的肋。 这种情况最好由塑料制成，连接件最好是热板焊接。 最优选地，面板和边缘构件具有带有内部肋的双皮肤结构，证明具有更大的强度并允许优异的结构特性，包括空气/水密的完整性。 边缘构件优选地形成有突起，以允许更好的基底到盖和壳到壳的接合。 可以有利地在模块化壳体上安装硬件，同时在附着点上分配力并且不影响结构完整性。

    METHOD AND APPARATUS FOR DETECTING CHEMICAL BINDING
    7.
    发明申请
    METHOD AND APPARATUS FOR DETECTING CHEMICAL BINDING 有权
    检测化学结合的方法和装置

    公开(公告)号：US20050011818A1

    公开(公告)日：2005-01-20

    申请号：US10621825

    申请日：2003-07-16

    申请人： Benjamin Warner ,  George Havrilla ,  Thomasin Miller ,  Cyndi Wells

    发明人： Benjamin Warner ,  George Havrilla ,  Thomasin Miller ,  Cyndi Wells

    IPC分类号： G01N23/223 ,  G01N33/53 ,  B01D35/14

    CPC分类号： G01N23/223 ,  G01N33/5306 ,  G01N2223/076 ,  Y10T436/13

    摘要： The method for screening binding between a target binder and potential pharmaceutical chemicals involves sending a solution (preferably an aqueous solution) of the target binder through a conduit to a size exclusion filter, the target binder being too large to pass through the size exclusion filter, and then sending a solution of one or more potential pharmaceutical chemicals (preferably an aqueous solution) through the same conduit to the size exclusion filter after target binder has collected on the filter. The potential pharmaceutical chemicals are small enough to pass through the filter. Afterwards, x-rays are sent from an x-ray source to the size exclusion filter, and if the potential pharmaceutical chemicals form a complex with the target binder, the complex produces an x-ray fluorescence signal having an intensity that indicates that a complex has formed.

    摘要翻译： 用于筛选目标粘合剂和潜在的药物化学药物之间的结合的方法包括将目标粘合剂的溶液（优选水溶液）通过导管送到尺寸排阻过滤器，目标粘合剂太大而不能通过尺寸排阻过滤器， 然后在将目标粘合剂收集在过滤器上之后，将一种或多种潜在的药物化学品（优选水溶液）的溶液通过相同的导管送至尺寸排阻过滤器。 潜在的药物化学品足够小以通过过滤器。 之后，将x射线从x射线源发送到尺寸排阻滤光片，如果潜在的药物化学品与靶结合物形成复合物，则复合物产生具有指示复合物的强度的X射线荧光信号 已形成。

    Flow method and apparatus for screening chemicals using micro x-ray fluorescence
    9.
    发明申请
    Flow method and apparatus for screening chemicals using micro x-ray fluorescence 审中-公开
    使用微X射线荧光筛选化学品的流动方法和装置

    公开(公告)号：US20050214847A1

    公开(公告)日：2005-09-29

    申请号：US11125036

    申请日：2005-05-09

    申请人： George Havrilla ,  Thomasin Miller ,  Benjamin Warner ,  Cris Lewis ,  Cynthia Mahan ,  Cyndi Wells

    发明人： George Havrilla ,  Thomasin Miller ,  Benjamin Warner ,  Cris Lewis ,  Cynthia Mahan ,  Cyndi Wells

    IPC分类号： G01N23/223 ,  C12Q1/68 ,  C12M1/34 ,  G01N33/53

    CPC分类号： G01N23/223 ,  G01N2223/076

    摘要： Flow method and apparatus for screening chemicals using micro x-ray fluorescence. The invention includes a method and apparatus for screening a mixture of potential pharmaceutical chemicals for binding to at least one target binder. According to the method, after preparing a solution of potential pharmaceutical chemicals with at least one target binder, the solution is flow-separated into at least two separated components. Each component is exposed to an x-ray excitation beam. Any component that emits a detectable x-ray fluorescence signal is isolated.

    摘要翻译： 使用微X射线荧光筛选化学品的流动方法和装置。 本发明包括用于筛选与至少一种目标粘合剂结合的潜在药物化学品混合物的方法和装置。 根据该方法，在制备具有至少一种目标粘合剂的潜在药物化学品溶液之后，将溶液流分离成至少两个分离的组分。 每个组件暴露于x射线激发光束。 发射可检测的X射线荧光信号的任何成分被分离出来。

    Dual fan hepa filtration system
    10.
    发明授权
    Dual fan hepa filtration system 失效
    双风扇肝素过滤系统

    公开(公告)号：US5358443A

    公开(公告)日：1994-10-25

    申请号：US47597

    申请日：1993-04-14

    申请人： Robert G. Mitchell ,  George Havrilla

    发明人： Robert G. Mitchell ,  George Havrilla

    IPC分类号： F24F3/16 ,  F24F7/007

    CPC分类号： F24F3/1603

    摘要： A device for use with at least one workspace, to produce an umbrella of clean room air for a distance of one meter from the device and 98% fewer particles than the air in the area three meters from the device. The device has a chamber defined by an outer wall, end walls and a filter as the inner wall. The filter functions as tile sole outlet of air. A motor with an axially extending drive shaft is mounted inside said filter. The shaft has an intake fan mounted on one end to define a sealed path which is the sole air inlet to the chamber. An exhaust fan is mounted on the other end of the shaft to define a path from the sole outlet. Air is exhausted in an axial direction is then deflected from the axial direction to the radial direction onto a baffle to reduce the velocity of the air to laminar flow. The baffle includes an upper terminal lid and a plurality of annular stepped vanes that divide the axially exhausted air into turbulent air streams and converts the turbulent air streams into radial laminar flow.

    摘要翻译： 用于与至少一个工作空间一起使用的装置，在与装置三米的区域中产生距离装置一米远的洁净室空气的伞和比空气少98％的颗粒。 该装置具有由外壁，端壁和作为内壁的过滤器限定的室。 过滤器用作空气的瓦片底部出口。 具有轴向延伸的驱动轴的马达安装在所述过滤器的内部。 轴具有安装在一端的进气风扇以限定作为室的唯一空气入口的密封路径。 排气风扇安装在轴的另一端以限定从鞋底出口的路径。 空气沿轴向排出然后从轴向方向偏转到挡板上，以降低空气流向层流的速度。 挡板包括上端子盖和多个环形台阶叶片，其将轴向排出的空气分成湍流空气流并将湍流空气流转换成径向层流。