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公开(公告)号：US07728034B2
公开(公告)日：2010-06-01
申请号：US11326264
申请日：2006-01-05
CPC分类号： A61K31/381 , A61K31/00 , A61K31/136 , A61K31/235 , A61K31/4439
摘要： The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
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2.发明授权Treating neurological disorders using selective antagonists of persistent sodium current 有权使用持续钠电流的选择性拮抗剂治疗神经障碍公开(公告)号：US08124612B2
公开(公告)日：2012-02-28
申请号：US11326263
申请日：2006-01-05
IPC分类号： A01N43/40 , A01N43/82 , A61K31/435 , A61K31/44 , A61K31/41
CPC分类号： A61K31/381 , A61K31/00 , A61K31/136 , A61K31/235 , A61K31/4439
摘要： The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
摘要翻译： 本发明提供了通过向哺乳动物施用有效量的相对于瞬时钠电流具有至少20倍的持续钠电流选择性的选择性持续性钠通道拮抗剂来治疗哺乳动物神经系统疾病的方法。
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3.发明授权Treating neurological disorders using selective antagonists of persistent sodium current 有权使用持续钠电流的选择性拮抗剂治疗神经障碍公开(公告)号：US07705055B2
公开(公告)日：2010-04-27
申请号：US11326036
申请日：2006-01-05
CPC分类号： A61K31/381 , A61K31/00 , A61K31/136 , A61K31/235 , A61K31/4439
摘要： The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
摘要翻译： 本发明提供了通过向哺乳动物施用有效量的相对于瞬时钠电流具有至少20倍的持续钠电流选择性的选择性持续性钠通道拮抗剂来治疗哺乳动物神经系统疾病的方法。
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公开(公告)号：US07060723B2
公开(公告)日：2006-06-13
申请号：US10928949
申请日：2004-08-27
CPC分类号： A61K31/381 , A61K31/00 , A61K31/136 , A61K31/235 , A61K31/4439
摘要： The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
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公开(公告)号：US07767718B2
公开(公告)日：2010-08-03
申请号：US11461517
申请日：2006-08-01
CPC分类号： A61K31/235 , A61K31/13 , A61K31/136 , A61K31/381 , A61K31/433 , A61K31/4439
摘要： The present invention provides methods of treating chronic pain in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
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6.发明授权公开(公告)号：US08153645B2
公开(公告)日：2012-04-10
申请号：US11461516
申请日：2006-08-01
IPC分类号： A01N43/40 , A01N43/82 , A61K31/435 , A61K31/44 , A61K31/41
CPC分类号： A61K31/235 , A61K31/13 , A61K31/136 , A61K31/381 , A61K31/433 , A61K31/4439
摘要： The present invention provides methods of treating chronic pain in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
摘要翻译： 本发明提供了通过向哺乳动物施用有效量的选择性持续性钠通道拮抗剂来治疗哺乳动物的慢性疼痛的方法，所述选择性持续性钠通道拮抗剂相对于瞬时钠电流具有至少20倍的持续钠电流选择性。
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7.发明授权公开(公告)号：US07763651B2
公开(公告)日：2010-07-27
申请号：US11461520
申请日：2006-08-01
CPC分类号： A61K31/235 , A61K31/13 , A61K31/136 , A61K31/381 , A61K31/433 , A61K31/4439
摘要： The present invention provides methods of treating chronic pain in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
摘要翻译： 本发明提供了通过向哺乳动物施用有效量的选择性持续性钠通道拮抗剂来治疗哺乳动物的慢性疼痛的方法，所述选择性持续性钠通道拮抗剂相对于瞬时钠电流具有至少20倍的持续钠电流选择性。
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8.发明授权公开(公告)号：US07125908B2
公开(公告)日：2006-10-24
申请号：US10928964
申请日：2004-08-27
CPC分类号： A61K31/235 , A61K31/13 , A61K31/136 , A61K31/381 , A61K31/433 , A61K31/4439
摘要： The present invention provides methods of treating chronic pain in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
摘要翻译： 本发明提供了通过向哺乳动物施用有效量的选择性持续性钠通道拮抗剂来治疗哺乳动物的慢性疼痛的方法，所述选择性持续性钠通道拮抗剂相对于瞬时钠电流具有至少20倍的持续钠电流选择性。
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9.发明授权High-throughput screen for identifying selective persistent sodium channels channel blockers 失效高通量屏幕，用于识别选择性持续性钠通道阻滞剂公开(公告)号：US07754440B2
公开(公告)日：2010-07-13
申请号：US12041739
申请日：2008-03-04
IPC分类号： G01N33/566 , G01N27/04 , C12N13/00 , G01R27/08 , C12M1/34
CPC分类号： G01N33/6872 , G01N2500/04 , G01N2500/10
摘要： A method for identifying a selective persistent Na+ channel blocker by measuring the ability of the blocker to reduce or inhibit a persistent Na+ current to a greater degree than a transient Na+ current. Aspects of the present method provide Na+ depletion/repletion methods for identifying a selective blocker of a persistent Na+ channel, hyperpolarization methods for identifying a blocker of a persistent Na+ channel, and Na/K ATPase pump inhibitor methods for identifying a selective blocker of a persistent Na+ channel.
摘要翻译： 一种用于通过测量阻断剂降低或抑制持久Na +电流比瞬态Na +电流更大程度的能力来鉴定选择性持续性Na +通道阻滞剂的方法。 本方法的方面提供用于鉴定持续性Na +通道的选择性阻断剂的Na +消耗/补充方法，用于鉴定持续性Na +通道阻滞剂的超极化方法，以及用于鉴定持续性Na +通道的选择性阻滞剂的Na / K ATP酶泵抑制剂方法 Na +通道。
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10.发明授权High-throughput screen for identifying selective persistent sodium channels channel blockers 失效高通量屏幕，用于识别选择性持续性钠通道阻滞剂公开(公告)号：US07361478B2
公开(公告)日：2008-04-22
申请号：US11313450
申请日：2005-12-19
IPC分类号： G01N33/566 , G01N27/04 , C12N13/00 , G01R27/08 , C12M1/34
CPC分类号： G01N33/6872 , G01N2500/04 , G01N2500/10
摘要： A method for identifying a selective persistent Na+ channel blocker by measuring the ability of the blocker to reduce or inhibit a persistent Na+ current to a greater degree than a transient Na+ current. Aspects of the present method provide Na+ depletion/repletion methods for identifying a selective blocker of a persistent Na+ channel, hyperpolarization methods for identifying a blocker of a persistent Na+ channel, and Na/K ATPase pump inhibitor methods for identifying a selective blocker of a persistent Na+ channel.
摘要翻译： 一种用于通过测量阻断剂减少或抑制持续性Na +电流的程度比暂时性Na +电流更大程度的能力来鉴定选择性持续性Na + SUP> + 当前。 本发明方法的方面提供用于鉴定持续性Na +通道的选择性阻断剂的Na + / / O>消耗/补充方法，用于鉴定持续性Na +通道阻滞剂的超极化方法， 和用于鉴定持续性Na +通道的选择性阻滞剂的Na / K ATP酶泵抑制剂方法。
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