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公开(公告)号：US20090112250A1
公开(公告)日：2009-04-30
申请号：US12337520
申请日：2008-12-17
IPC分类号： A61M29/04
CPC分类号： A61L31/146 , A61B17/12022 , A61B17/12113 , A61B17/12186 , A61B17/1219 , A61B34/10 , A61B2017/00526 , A61B2017/1205 , A61F2/06 , A61L31/145 , A61L31/18 , A61L2430/36 , B33Y50/00 , B33Y80/00 , Y10S623/901 , Y10S623/903 , Y10T29/49
摘要： A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.
摘要翻译： 由可压缩泡沫材料形成的血管植入物具有压缩构型，其可膨胀到基本上符合要栓塞的血管部位的形状和尺寸的构造。 优选地，植入物由亲水的大孔泡沫材料形成，具有血管部位的缩小模型的初始构型，从而可压缩成压缩构型。 通过扫描血管部位来创建植入物以产生数字化的扫描数据集; 使用扫描数据集创建血管部位的三维数字化虚拟模型; 使用虚拟模型创建血管部位的缩小物理模具; 并使用模具以血管部位的缩小模型的形式产生血管植入物。 为了栓塞血管部位，植入物被压缩并通过微导管，其远端已经进入血管部位。 在进入血管部位时，植入物基本上扩张以填充血管部位。 保持元件容纳在微导管内并且具有可拆卸地连接到植入物的远端。 使用柔性的管状展开元件将植入物和保持元件通过微导管，然后当植入物从微导管通过并进入血管部位时，将植入物与保留元件分离。
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公开(公告)号：US20110005062A1
公开(公告)日：2011-01-13
申请号：US12877906
申请日：2010-09-08
IPC分类号： B23P17/04
CPC分类号： A61L31/146 , A61B17/12022 , A61B17/12113 , A61B17/12186 , A61B17/1219 , A61B34/10 , A61B2017/00526 , A61B2017/1205 , A61F2/06 , A61L31/145 , A61L31/18 , A61L2430/36 , B33Y50/00 , B33Y80/00 , Y10S623/901 , Y10S623/903 , Y10T29/49
摘要： A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.
摘要翻译： 由可压缩泡沫材料形成的血管植入物具有压缩构型，其可膨胀到基本上符合要栓塞的血管部位的形状和尺寸的构造。 优选地，植入物由亲水的大孔泡沫材料形成，具有血管部位的缩小模型的初始构型，从而可压缩成压缩构型。 通过扫描血管部位来创建植入物以产生数字化的扫描数据集; 使用扫描数据集创建血管部位的三维数字化虚拟模型; 使用虚拟模型创建血管部位的缩小物理模具; 并使用模具以血管部位的缩小模型的形式产生血管植入物。 为了栓塞血管部位，植入物被压缩并通过微导管，其远端已经进入血管部位。 在进入血管部位时，植入物基本上扩张以填充血管部位。 保持元件容纳在微导管内并且具有可拆卸地连接到植入物的远端。 使用柔性的管状展开元件将植入物和保持元件通过微导管，然后当植入物从微导管通过并进入血管部位时，将植入物与保留元件分离。
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公开(公告)号：US20090232869A1
公开(公告)日：2009-09-17
申请号：US12362466
申请日：2009-01-29
CPC分类号： B29C70/74 , A61B17/12022 , A61B17/12113 , A61B17/12118 , A61B17/12145 , A61B17/12154 , A61B17/12163 , A61B17/1219 , A61B2017/00004 , A61B2017/00526 , A61B2017/1205 , A61L31/022 , A61L31/145 , A61L31/18 , A61L2430/36 , B29L2031/7542
摘要： An embolization device for occluding a body cavity includes one or more elongated, expansible, hydrophilic embolizing elements non-releasably carried along the length of an elongated filamentous carrier that is preferably made of a very thin, highly flexible filament or microcoil of nickel/titanium alloy. At least one expansile embolizing element is non-releasably attached to the carrier. A first embodiment includes a plurality of embolizing elements fixed to the carrier at spaced-apart intervals along its length. In second, third and fourth embodiments, an elongate, continuous, coaxial embolizing element is non-releasably fixed to the exterior surface of the carrier, extending along a substantial portion of the length of the carrier proximally from a distal tip, and optionally includes a lumenal reservoir for delivery of therapeutic agents. Exemplary methods for making these devices include skewering and molding the embolizing elements. In any of the embodiments, the embolizing elements may be made of a hydrophilic, macroporous, polymeric, hydrogel foam material. In the second, third and fourth embodiments, the elongate embolizing element is preferably made of a porous, environmentally-sensitive, expansile hydrogel, which can optionally be made biodegradable and/or bioresorbable, having a rate of expansion that changes in response to a change in an environmental parameter, such as the pH or temperature of the environment.
摘要翻译： 用于封闭体腔的栓塞装置包括一个或多个细长的，可膨胀的亲水性栓塞元件，其不可释放地沿着细长丝状载体的长度承载，优选由非常薄的，高度柔性的细丝或镍/钛合金的微线圈 。 至少一个膨胀栓塞元件不可释放地附接到载体上。 第一实施例包括沿其长度以间隔间隔固定到载体的多个栓塞元件。 在第二，第三和第四实施例中，细长的，连续的同轴栓塞元件不可释放地固定到承载件的外表面上，其沿着承载件的长度的大部分从远侧末端向近侧延伸，并且可选地包括 用于递送治疗剂的腔内贮存器。 用于制造这些装置的示例性方法包括串联和模制栓塞元件。 在任何实施例中，栓塞元件可以由亲水的，大孔的，聚合的，水凝胶泡沫材料制成。 在第二，第三和第四实施例中，细长栓塞元件优选地由多孔，环境敏感的可膨胀水凝胶制成，其可任选地被制成可生物降解和/或生物可再吸收的，具有响应于变化而变化的膨胀率 在环境参数中，例如pH或环境温度。
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